Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect MO Bergo, B Gavino, J Ross, WK Schmidt, C Hong, LV Kendall, A Mohr, ... Proceedings of the National Academy of Sciences 99 (20), 13049-13054, 2002 | 520 | 2002 |
Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage WK Schmidt, A Tam, K Fujimura-Kamada, S Michaelis Proceedings of the National Academy of Sciences 95 (19), 11175-11180, 1998 | 270 | 1998 |
Ste6p Mutants Defective in Exit from the Endoplasmic Reticulum (ER) Reveal Aspects of an ER Quality Control Pathway inSaccharomyces cerevisiae D Loayza, A Tam, WK Schmidt, S Michaelis Molecular biology of the cell 9 (10), 2767-2784, 1998 | 155 | 1998 |
The Saccharomyces cerevisiae Prenylcysteine Carboxyl Methyltransferase Ste14p Is in the Endoplasmic Reticulum Membrane JD Romano, WK Schmidt, S Michaelis Molecular biology of the cell 9 (8), 2231-2247, 1998 | 148 | 1998 |
Biochemical studies of Zmpste24-deficient mice GK Leung, WK Schmidt, MO Bergo, B Gavino, DH Wong, A Tam, ... Journal of Biological Chemistry 276 (31), 29051-29058, 2001 | 113 | 2001 |
The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor A Tam, WK Schmidt, S Michaelis Journal of Biological Chemistry 276 (50), 46798-46806, 2001 | 86 | 2001 |
Ionic milieu controls the compartment-specific activation of pro-opiomelanocortin processing in AtT-20 cells. WK Schmidt, HP Moore Molecular biology of the cell 6 (10), 1271-1285, 1995 | 83 | 1995 |
Small-molecule inhibitors of the Rce1p CaaX protease SP Manandhar, ER Hildebrandt, WK Schmidt Journal of biomolecular screening 12 (7), 983-993, 2007 | 80 | 2007 |
Reconstitution of the Ste24p-dependent N-terminal proteolytic step in yeast a-factor biogenesis WK Schmidt, A Tam, S Michaelis Journal of biological chemistry 275 (9), 6227-6233, 2000 | 66 | 2000 |
8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells I Mohammed, SE Hampton, L Ashall, ER Hildebrandt, RA Kutlik, ... Bioorganic & medicinal chemistry 24 (2), 160-178, 2016 | 60 | 2016 |
Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues LJ Plummer, ER Hildebrandt, SB Porter, VA Rogers, J McCracken, ... Journal of Biological Chemistry 281 (8), 4596-4605, 2006 | 59 | 2006 |
Rce1: mechanism and inhibition SE Hampton, TM Dore, WK Schmidt Critical reviews in biochemistry and molecular biology 53 (2), 157-174, 2018 | 55 | 2018 |
AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes J Cadiñanos, I Varela, DA Mandel, WK Schmidt, A Díaz-Perales, ... Journal of Biological Chemistry 278 (43), 42091-42097, 2003 | 55 | 2003 |
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy) methyl ketones SB Porter, ER Hildebrandt, SR Breevoort, DZ Mokry, TM Dore, ... Biochimica Et Biophysica Acta (BBA)-Molecular Cell Research 1773 (6), 853-862, 2007 | 50 | 2007 |
The yeast a-factor transporter Ste6p, a member of the ABC superfamily, couples ATP hydrolysis to pheromone export CJ Ketchum, WK Schmidt, GV Rajendrakumar, S Michaelis, PC Maloney Journal of Biological Chemistry 276 (31), 29007-29011, 2001 | 50 | 2001 |
Efficient farnesylation of an extended C-terminal C (x) 3X sequence motif expands the scope of the prenylated proteome MJ Blanden, KF Suazo, ER Hildebrandt, DS Hardgrove, M Patel, ... Journal of Biological Chemistry 293 (8), 2770-2785, 2018 | 49 | 2018 |
A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes ER Hildebrandt, M Cheng, P Zhao, JH Kim, L Wells, WK Schmidt Elife 5, e15899, 2016 | 37 | 2016 |
Anion activation site of insulin-degrading enzyme N Noinaj, ES Song, S Bhasin, BJ Alper, WK Schmidt, LB Hersh, ... Journal of biological chemistry 287 (1), 48-57, 2012 | 35 | 2012 |
Chemical inhibition of CaaX protease activity disrupts yeast Ras localization SP Manandhar, ER Hildebrandt, WH Jacobsen, GM Santangelo, ... Yeast 27 (6), 327-343, 2010 | 35 | 2010 |
Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme S Kim, AN Lapham, CGK Freedman, TL Reed, WK Schmidt Journal of Biological Chemistry 280 (30), 27481-27490, 2005 | 35 | 2005 |