| (‐) Epicatechin stimulates ERK‐dependent cyclic AMP response element activity and up‐regulates GluR2 in cortical neurons H Schroeter, P Bahia, JPE Spencer, O Sheppard, M Rattray, E Cadenas, ... Journal of neurochemistry 101 (6), 1596-1606, 2007 | 198 | 2007 |
| Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta O Sheppard, MP Coleman, CS Durrant Journal of neuroinflammation 16, 1-13, 2019 | 134 | 2019 |
| Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP FK Wiseman, LJ Pulford, C Barkus, F Liao, E Portelius, R Webb, ... Brain 141 (8), 2457-2474, 2018 | 128 | 2018 |
| Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome SM Gribble, FK Wiseman, S Clayton, E Prigmore, E Langley, F Yang, ... PloS one 8 (4), e60482, 2013 | 109 | 2013 |
| Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML F Basheer, G Giotopoulos, E Meduri, H Yun, M Mazan, D Sasca, ... Journal of Experimental Medicine 216 (4), 966-981, 2019 | 102 | 2019 |
| Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F L Zhang, OR Sheppard, AM Shah, AC Brewer Free Radical Biology and Medicine 45 (5), 679-685, 2008 | 83 | 2008 |
| Alzheimer’s disease: etiology, neuropathology and pathogenesis O Sheppard, M Coleman Exon Publications, 1-21, 2020 | 76 | 2020 |
| Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors SJ Horton, G Giotopoulos, H Yun, S Vohra, O Sheppard, ... Nature cell biology 19 (9), 1093-1104, 2017 | 69 | 2017 |
| Altered regulation of tau phosphorylation in a mouse model of down syndrome aging O Sheppard, F Plattner, A Rubin, A Slender, JM Linehan, S Brandner, ... Neurobiology of aging 33 (4), 828. e31-828. e44, 2012 | 65 | 2012 |
| Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons J Qiu, J McQueen, B Bilican, O Dando, D Magnani, K Punovuori, ... Elife 5, e20337, 2016 | 36 | 2016 |
| Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling CS Durrant, K Ruscher, O Sheppard, MP Coleman, I Özen Cell death & disease 11 (2), 98, 2020 | 31 | 2020 |
| Mouse models of aneuploidy O Sheppard, FK Wiseman, A Ruparelia, VLJ Tybulewicz, E Fisher The Scientific World Journal 2012, 2012 | 19 | 2012 |
| Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue LVC Miller, AS Mukadam, CS Durrant, MJ Vaysburd, T Katsinelos, ... Acta Neuropathologica Communications 9, 1-16, 2021 | 18 | 2021 |
| Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21 A Ruparelia, F Wiseman, O Sheppard, VLJ Tybulewicz, EMC Fisher Journal of biomedical research 24 (2), 87-99, 2010 | 18 | 2010 |
| London Down syndrome consortium, Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium. Trisomy of human … FK Wiseman, LJ Pulford, C Barkus, F Liao, E Portelius, R Webb, ... Brain 141 (8), 2457-2474, 2018 | 15 | 2018 |
| Generation of a panel of antibodies against proteins encoded on human chromosome 21 FK Wiseman, O Sheppard, JM Linehan, S Brandner, VLJ Tybulewicz, ... Journal of negative results in biomedicine 9, 1-12, 2010 | 3 | 2010 |
| Early loss of CREBBP confers malignant stem cell properties on lymphoid progenitors BJP Huntly, SJ Horton, G Giotopoulos, H Yun, S Vohra, O Sheppard, ... Blood 128 (22), 460, 2016 | 1 | 2016 |
| Lowering glucose enhances BACE1 activity and Aβ generation in mouse brain slice cultures O Sheppard, R Humphrey, CS Durrant, MP Coleman bioRxiv, 2024.03. 12.584616, 2024 | | 2024 |
| Revealing Mechanisms of Sporadic Alzheimer’s Disease by Modelling in Organotypic Hippocampal Slice Cultures O Sheppard | | 2022 |
| Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue AS Mukadam, LVC Miller, CS Durrant, MJ Vaysburd, T Katsinelos, ... bioRxiv, 2021.01. 13.426340, 2021 | | 2021 |
