Stephen Neidle

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Gary ParkinsonUCL school of pharmacyVerified email at ucl.ac.uk
Shozeb HaiderUCL School of PharmacyVerified email at ucl.ac.uk
W. David WilsonRegents’ ProfessorVerified email at gsu.edu
Shankar BalasubramanianUniversity of CambridgeVerified email at cam.ac.uk
alan toddNIHR GSTFT/KCL Comprehensive Biomedical Research CentreVerified email at kcl.ac.uk
Helen M. BermanProfessor of Chemistry and Chemical BiologyVerified email at rcsb.rutgers.edu
Gavin CollieAstraZenecaVerified email at icr.ac.uk
Laurence HurleyProfessor of Medicinal Chemistry, CSO ReglageneVerified email at pharmacy.arizona.edu
ramon vilarImperial College LondonVerified email at imperial.ac.uk
Nancy H CampbellSenior Biocurator at HealxVerified email at healx.io
Sarah BurgeDepartment of Oncology, University of CambridgeVerified email at cam.ac.uk
Garry TaylorEmeritus Professor of Molecular Biophysics, University of St AndrewsVerified email at st-andrews.ac.uk
Julie E ReedImperial College LondonVerified email at imperial.ac.uk
Aaron G DaleGraduate Medical Student, Oxford University Verified email at medschool.ox.ac.uk
Aneel AggarwalProfessor, Icahn School of Medicine at Mount SinaiVerified email at mssm.edu
Dinshaw J. PatelMemorial Sloan-Kettering Cancer CenterVerified email at mskcc.org
Jean-Francois RiouMNHNVerified email at mnhn.fr
Bohdan SchneiderHead of Laboratory of Biomolecular Rcognition and Dir, Institute of Biotechnology, Czech AcademyVerified email at ibt.cas.cz

Stephen Neidle

Emeritus Professor of Chemical Biology, The UCL School of Pharmacy, University of London

Verified email at ucl.ac.uk - Homepage

drug design and discovery cancer nucleic acid structure quadruplex nucleic acids chemical biology


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Quadruplex DNA: sequence, topology and structure S Burge, GN Parkinson, P Hazel, AK Todd, S Neidle Nucleic acids research 34 (19), 5402-5415, 2006	2684	2006
Crystal structure of parallel quadruplexes from human telomeric DNA GN Parkinson, MPH Lee, S Neidle Nature 417 (6891), 876-880, 2002	2388	2002
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? S Balasubramanian, LH Hurley, S Neidle Nature reviews Drug discovery 10 (4), 261-275, 2011	1790	2011
Nucleic acids in chemistry and biology GM Blackburn Royal Society of Chemistry, 2006	1354	2006
Highly prevalent putative quadruplex sequence motifs in human DNA AK Todd, M Johnston, S Neidle Nucleic acids research 33 (9), 2901-2907, 2005	1152	2005
Inhibition of human telomerase by a G-quadruplex-interactive compound D Sun, B Thompson, BE Cathers, M Salazar, SM Kerwin, JO Trent, ... Journal of medicinal chemistry 40 (14), 2113-2116, 1997	1100	1997
Telomere maintenance as a target for anticancer drug discovery S Neidle, G Parkinson Nature Reviews Drug Discovery 1 (5), 383-393, 2002	805	2002
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function AM Burger, F Dai, CM Schultes, AP Reszka, MJ Moore, JA Double, ... Cancer research 65 (4), 1489-1496, 2005	731	2005
A standard reference frame for the description of nucleic acid base-pair geometry WK Olson, M Bansal, SK Burley, RE Dickerson, M Gerstein, SC Harvey, ... Journal of molecular biology 313 (1), 229-237, 2001	713	2001
Putative DNA Quadruplex Formation within the Human c-kit Oncogene S Rankin, AP Reszka, J Huppert, M Zloh, GN Parkinson, AK Todd, ... Journal of the American Chemical Society 127 (30), 10584-10589, 2005	675	2005
Human telomeric G‐quadruplex: The current status of telomeric G‐quadruplexes as therapeutic targets in human cancer S Neidle The FEBS journal 277 (5), 1118-1125, 2010	661	2010
G-quadruplex nucleic acids as therapeutic targets S Balasubramanian, S Neidle Current opinion in chemical biology 13 (3), 345-353, 2009	651	2009
DNA minor-groove recognition by small molecules S Neidle Natural product reports 18 (3), 291-309, 2001	642	2001
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors M Read, RJ Harrison, B Romagnoli, FA Tanious, SH Gowan, AP Reszka, ... Proceedings of the National Academy of Sciences 98 (9), 4844-4849, 2001	630	2001
Quadruplex nucleic acids as novel therapeutic targets S Neidle Journal of medicinal chemistry 59 (13), 5987-6011, 2016	588	2016
The structure of telomeric DNA S Neidle, GN Parkinson Current opinion in structural biology 13 (3), 275-283, 2003	579	2003
Quadruplex nucleic acids S Neidle, S Balasubramanian Royal Society of Chemistry, 2006	563	2006
Loop-length-dependent folding of G-quadruplexes P Hazel, J Huppert, S Balasubramanian, S Neidle Journal of the American Chemical Society 126 (50), 16405-16415, 2004	551	2004
The structures of quadruplex nucleic acids and their drug complexes S Neidle Current opinion in structural biology 19 (3), 239-250, 2009	525	2009
Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter AT Phan, V Kuryavyi, S Burge, S Neidle, DJ Patel Journal of the American Chemical Society 129 (14), 4386-4392, 2007	507	2007

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