Siddharth Balachandran
Siddharth Balachandran
Fox Chase Cancer Center
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Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection
S Balachandran, PC Roberts, LE Brown, H Truong, AK Pattnaik, ...
Immunity 13 (1), 129-141, 2000
Activation of the dsRNA‐dependent protein kinase, PKR, induces apoptosis through FADD‐mediated death signaling
S Balachandran, CN Kim, WC Yeh, TW Mak, K Bhalla, GN Barber
The EMBO journal 17 (23), 6888-6902, 1998
Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes
N Grandvaux, MJ Servant, GC Sen, S Balachandran, GN Barber, R Lin, ...
Journal of virology 76 (11), 5532-5539, 2002
Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway
S Balachandran, PC Roberts, T Kipperman, KN Bhalla, RW Compans, ...
Journal of virology 74 (3), 1513-1523, 2000
A FADD-dependent innate immune mechanism in mammalian cells
S Balachandran, E Thomas, GN Barber
Nature 432 (7015), 401-405, 2004
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
RJ Thapa, S Nogusa, P Chen, JL Maki, A Lerro, M Andrake, GF Rall, ...
Proceedings of the National Academy of Sciences 110 (33), E3109-E3118, 2013
Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or myc function and involves the induction of apoptosis
S Balachandran, M Porosnicu, GN Barber
Journal of virology 75 (7), 3474-3479, 2001
Defective translational control facilitates vesicular stomatitis virus oncolysis
S Balachandran, GN Barber
Cancer cell 5 (1), 51-65, 2004
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
WJ Kaiser, LP Daley-Bauer, RJ Thapa, P Mandal, SB Berger, C Huang, ...
Proceedings of the National Academy of Sciences 111 (21), 7753-7758, 2014
Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent …
A Pataer, SA Vorburger, GN Barber, S Chada, AM Mhashilkar, ...
Cancer research 62 (8), 2239-2243, 2002
Vesicular stomatitis virus (VSV) therapy of tumors
S Balachandran, GN Barber
IUBMB life 50 (2), 135-138, 2000
The IRF-3 transcription factor mediates Sendai virus-induced apoptosis
C Heylbroeck, S Balachandran, MJ Servant, C DeLuca, GN Barber, R Lin, ...
Journal of virology 74 (8), 3781-3792, 2000
RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus
S Nogusa, RJ Thapa, CP Dillon, S Liedmann, TH Oguin III, JP Ingram, ...
Cell host & microbe 20 (1), 13-24, 2016
DAI senses influenza A virus genomic RNA and activates RIPK3-dependent cell death
RJ Thapa, JP Ingram, KB Ragan, S Nogusa, DF Boyd, AA Benitez, ...
Cell host & microbe 20 (5), 674-681, 2016
Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells
D Olagnier, S Peri, C Steel, N van Montfoort, C Chiang, V Beljanski, ...
PLoS pathogens 10 (12), 2014
Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and-2, that function in mRNA processing and interact with the double …
LR Saunders, DJ Perkins, S Balachandran, R Michaels, R Ford, ...
Journal of Biological Chemistry 276 (34), 32300-32312, 2001
NF-κB RelA subunit is crucial for early IFN-β expression and resistance to RNA virus replication
J Wang, SH Basagoudanavar, X Wang, E Hopewell, R Albrecht, ...
The Journal of Immunology 185 (3), 1720-1729, 2010
RIPK1 and RIPK3 kinases promote cell-death-independent inflammation by Toll-like receptor 4
M Najjar, D Saleh, M Zelic, S Nogusa, S Shah, A Tai, JN Finger, ...
Immunity 45 (1), 46-59, 2016
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
S Rao, SY Lee, A Gutierrez, J Perrigoue, RJ Thapa, Z Tu, JR Jeffers, ...
Blood 120 (18), 3764-3773, 2012
The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism
AG Goodman, JA Smith, S Balachandran, O Perwitasari, SC Proll, ...
Journal of virology 81 (5), 2221-2230, 2007
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