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Timothy J Knowles
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Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer
TJ Knowles, R Finka, C Smith, YP Lin, T Dafforn, M Overduin
Journal of the American Chemical Society 131 (22), 7484-7485, 2009
6262009
A method for detergent-free isolation of membrane proteins in their local lipid environment
SC Lee, TJ Knowles, VLG Postis, M Jamshad, RA Parslow, YP Lin, ...
Nature protocols 11 (7), 1149-1162, 2016
4192016
Membrane protein architects: the role of the BAM complex in outer membrane protein assembly
TJ Knowles, A Scott-Tucker, M Overduin, IR Henderson
Nature Reviews Microbiology 7 (3), 206-214, 2009
4112009
Detergent-free purification of ABC (ATP-binding-cassette) transporters
S Gulati, M Jamshad, TJ Knowles, KA Morrison, R Downing, N Cant, ...
Biochemical Journal 461 (2), 269-278, 2014
2482014
Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins
M Jamshad, V Grimard, I Idini, TJ Knowles, MR Dowle, N Schofield, ...
Nano Research 8, 774-789, 2015
2302015
Butyrophilin-2A1 directly binds germline-encoded regions of the Vγ9Vδ2 TCR and is essential for phosphoantigen sensing
MM Karunakaran, CR Willcox, M Salim, D Paletta, AS Fichtner, A Noll, ...
Immunity 52 (3), 487-498. e6, 2020
2252020
G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent
M Jamshad, J Charlton, YP Lin, SJ Routledge, Z Bawa, TJ Knowles, ...
Bioscience reports 35 (2), e00188, 2015
2132015
Fold and function of polypeptide transport‐associated domains responsible for delivering unfolded proteins to membranes
TJ Knowles, M Jeeves, S Bobat, F Dancea, D McClelland, T Palmer, ...
Molecular microbiology 68 (5), 1216-1227, 2008
2092008
Membrane protein extraction and purification using styrene–maleic acid (SMA) copolymer: effect of variations in polymer structure
KA Morrison, A Akram, A Mathews, ZA Khan, JH Patel, C Zhou, DJ Hardy, ...
Biochemical Journal 473 (23), 4349-4360, 2016
1622016
Surfactant-free purification of membrane proteins with intact native membrane environment
M Jamshad, YP Lin, TJ Knowles, RA Parslow, C Harris, M Wheatley, ...
Biochemical Society Transactions 39 (3), 813-818, 2011
1352011
Structure and function of BamE within the outer membrane and the β‐barrel assembly machine
TJ Knowles, DF Browning, M Jeeves, R Maderbocus, S Rajesh, P Sridhar, ...
EMBO reports 12 (2), 123-128, 2011
1232011
Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system
GW Hughes, SCL Hall, CS Laxton, P Sridhar, AH Mahadi, C Hatton, ...
Nature microbiology 4 (10), 1692-1705, 2019
1172019
An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles
SCL Hall, C Tognoloni, J Charlton, ÉC Bragginton, AJ Rothnie, P Sridhar, ...
Nanoscale 10 (22), 10609-10619, 2018
1112018
The essential β-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis
AE Rossiter, DL Leyton, K Tveen-Jensen, DF Browning, ...
Journal of bacteriology 193 (16), 4250-4253, 2011
1052011
BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain
M Salim, TJ Knowles, AT Baker, MS Davey, M Jeeves, P Sridhar, J Wilkie, ...
ACS chemical biology 12 (10), 2631-2643, 2017
702017
MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis
GL Isom, NJ Davies, ZS Chong, JA Bryant, M Jamshad, M Sharif, ...
Scientific reports 7 (1), 8608, 2017
672017
Production of membrane proteins without cells or detergents
S Rajesh, T Knowles, M Overduin
New Biotechnology 28 (3), 250-254, 2011
662011
Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR
M Conner, MR Hicks, T Dafforn, TJ Knowles, C Ludwig, S Staddon, ...
Biochemistry 47 (32), 8434-8444, 2008
592008
Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection
LR Machado, RJ Hardwick, J Bowdrey, H Bogle, TJ Knowles, M Sironi, ...
The American Journal of Human Genetics 90 (6), 973-985, 2012
512012
Peptidoglycan maturation controls outer membrane protein assembly
G Mamou, F Corona, R Cohen-Khait, NG Housden, V Yeung, D Sun, ...
Nature 606 (7916), 953-959, 2022
502022
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