Sven Lindner
Sven Lindner
University Hospital Essen
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
JJ Molenaar, R Domingo-Fernández, ME Ebus, S Lindner, J Koster, ...
Nature genetics 44 (11), 1199-1206, 2012
Histone deacetylase 10 promotes autophagy-mediated cell survival
I Oehme, JP Linke, BC Böck, T Milde, M Lodrini, B Hartenstein, I Wiegand, ...
Proceedings of the National Academy of Sciences 110 (28), E2592-E2601, 2013
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice
LC Heukamp, T Thor, A Schramm, K De Preter, C Kumps, B De Wilde, ...
Science translational medicine 4 (141), 141ra91-141ra91, 2012
Targeting MYCN-driven transcription by BET-bromodomain inhibition
A Henssen, K Althoff, A Odersky, A Beckers, R Koche, F Speleman, ...
Clinical Cancer Research 22 (10), 2470-2481, 2016
MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells
JH Schulte, S Lindner, A Bohrer, J Maurer, K De Preter, S Lefever, ...
Oncogene 32 (8), 1059-1065, 2013
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
K Althoff, A Beckers, E Bell, M Nortmeyer, T Thor, A Sprüssel, S Lindner, ...
Oncogene 34 (26), 3357-3368, 2015
miR‐542‐3p exerts tumor suppressive functions in neuroblastoma by downregulating S urvivin
K Althoff, S Lindner, A Odersky, P Mestdagh, A Beckers, S Karczewski, ...
International journal of cancer 136 (6), 1308-1320, 2015
Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation
KB Emdal, AK Pedersen, DB Bekker-Jensen, KP Tsafou, H Horn, ...
Science signaling 8 (374), ra40-ra40, 2015
Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma
EE Santo, ME Ebus, J Koster, JH Schulte, A Lakeman, P Van Sluis, ...
Oncogene 31 (12), 1571-1581, 2012
Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma: implications for targeted treatment
I Lambertz, C Kumps, S Claeys, S Lindner, A Beckers, E Janssens, ...
Clinical Cancer Research 21 (14), 3327-3339, 2015
Evaluation of renormalised entropy for risk stratification using heart rate variability data
N Wessel, A Voss, J Kurths, A Schirdewan, K Hnatkova, M Malik
Medical and Biological Engineering and Computing 38 (6), 680-685, 2000
Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells
KW Pajtler, E Mahlow, A Odersky, S Lindner, H Stephan, I Bendix, ...
Oncotarget 5 (22), 11180, 2014
p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomas
D Dreidax, S Bannert, KO Henrich, C Schröder, S Bender, CC Oakes, ...
Human molecular genetics 23 (25), 6826-6837, 2014
Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma
S Lindner, HS Bachmann, A Odersky, S Schaefers, L Klein‑Hitpass, ...
Biomedical Reports 3 (4), 443-446, 2015
The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models
KW Pajtler, N Sadowski, S Ackermann, K Althoff, K Schönbeck, K Batzke, ...
Oncotarget 8 (4), 6730, 2017
Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma
Y Han, S Lindner, Y Bei, HD Garcia, N Timme, K Althoff, A Odersky, ...
Cancer Letters 445, 24-33, 2019
Impact of metformin on advanced pancreatic cancer survival: too little, too late?
YX Yang, AK Rustgi
Clinical Cancer Research 22 (5), 1031-1033, 2016
Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum
AK Wefers, S Lindner, JH Schulte, U Schüller
The Cerebellum 16 (1), 122-131, 2017
The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease
B De Wilde, A Beckers, S Lindner, A Kristina, K De Preter, P Depuydt, ...
Oncotarget 9 (9), 8334, 2018
ALK pERKs up MYCN in neuroblastoma
S Lindner, A Henssen, K Astrahantseff, JH Schulte
Science signaling 7 (349), pe27-pe27, 2014
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