Takashi Ochi
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PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
T Ochi, AN Blackford, J Coates, S Jhujh, S Mehmood, N Tamura, ...
Science 347 (6218), 185-188, 2015
Different DNA end configurations dictate which NHEJ components are most important for joining efficiency
HHY Chang, G Watanabe, CA Gerodimos, T Ochi, TL Blundell, ...
Journal of Biological Chemistry 291 (47), 24377-24389, 2016
Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions
W Qian, O Takashi, MV Dijana, VR Carol, YC Dimitri, LB Tom
Biochemical Society Transactions 39 (5), 1387-1392, 2011
The spatial organization of non-homologous end joining: from bridging to end joining
T Ochi, Q Wu, TL Blundell
DNA repair 17, 98-109, 2014
Mutations in the NHEJ component XRCC4 cause primordial dwarfism
JE Murray, M Van Der Burg, H IJspeert, P Carroll, Q Wu, T Ochi, A Leitch, ...
The American Journal of Human Genetics 96 (3), 412-424, 2015
Dissection of DNA double-strand-break repair using novel single-molecule forceps
JL Wang, C Duboc, Q Wu, T Ochi, S Liang, SE Tsutakawa, SP Lees-Miller, ...
Nature structural & molecular biology 25 (6), 482-487, 2018
Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair
T Ochi, X Gu, TL Blundell
Structure 21 (4), 672-679, 2013
Structure of BRCA1-BRCT/Abraxas complex reveals phosphorylation-dependent BRCT dimerization at DNA damage sites
Q Wu, A Paul, D Su, S Mehmood, TK Foo, T Ochi, EL Bunting, B Xia, ...
Molecular cell 61 (3), 434-448, 2016
Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV
T Ochi, Q Wu, DY Chirgadze, JG Grossmann, VM Bolanos-Garcia, ...
Structure, 2012
Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining
T Ochi, BL Sibanda, Q Wu, DY Chirgadze, VM Bolanos-Garcia, ...
Journal of nucleic acids 2010, 2010
Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems
VM Bolanos-Garcia, Q Wu, T Ochi, DY Chirgadze, BL Sibanda, ...
Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2012
Investigations into protein crystallization in the presence of a strong magnetic field
S Surade, T Ochi, D Nietlispach, D Chirgadze, A Moreno
Crystal growth & design 10 (2), 691-699, 2010
Perspectives on protein crystallisation
T Ochi, VM Bolanos-Garcia, V Stojanoff, A Moreno
Progress in biophysics and molecular biology 101 (1), 56-63, 2009
Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways
Q Wu, S Liang, T Ochi, DY Chirgadze, JT Huiskonen, TL Blundell
Progress in Biophysics and Molecular Biology 147, 26-32, 2019
Protein-protein interactions: structures and druggability
DB Ascher, HC Jubb, DEV Pires, T Ochi, A Higueruelo, TL Blundell
Multifaceted roles of crystallography in modern drug discovery, 141-163, 2015
CCDC61/VFL3 is a paralog of SAS6 and promotes ciliary functions
T Ochi, V Quarantotti, H Lin, J Jullien, IR e Silva, F Boselli, DD Barnabas, ...
Structure 28 (6), 674-689. e11, 2020
Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached
S Liang, SR Esswein, T Ochi, Q Wu, DB Ascher, D Chirgadze, BL Sibanda, ...
Structural Chemistry 28, 161-171, 2017
Catalytically inactive DNA ligase IV promotes DNA repair in living cells
NJ Goff, M Brenière, CJ Buehl, AJ de Melo, H Huskova, T Ochi, ...
Nucleic Acids Research 50 (19), 11058-11071, 2022
Plant PAXX has an XLF‐like function and stimulates DNA end‐joining by the Ku‐DNA ligase IV‐XRCC4 complex
H Khan, T Ochi
The Plant Journal, 2023
Spatial and temporal organisation of multiprotein systems of cell regulation and signalling: What can we learn from NHEJ system of double-strand break repair?
Q Wu, L Sibanda, T Ochi, VM Bolanos-Garcia, TL Blundell, DY Chirgadze
Macromolecular Crystallography: Deciphering the Structure, Function and …, 2012
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