Shane Robert Wilkinson
Shane Robert Wilkinson
Verified email at qmul.ac.uk - Homepage
TitleCited byYear
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
SR Wilkinson, MC Taylor, D Horn, JM Kelly, I Cheeseman
Proceedings of the National Academy of Sciences 105 (13), 5022-5027, 2008
3052008
Trypanocidal drugs: mechanisms, resistance and new targets
SR Wilkinson, JM Kelly
Expert reviews in molecular medicine 11, 2009
1902009
Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites
BS Hall, C Bot, SR Wilkinson
Journal of Biological Chemistry 286 (15), 13088-13095, 2011
1832011
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi
SR Wilkinson, NJ Temperton, A Mondragon, JM Kelly
Journal of Biological Chemistry 275 (11), 8220-8225, 2000
1702000
Spo0A directly controls the switch from acid to solvent production in solvent‐forming clostridia
A Ravagnani, KCB Jennert, E Steiner, R Grünberg, JR Jefferies, ...
Molecular microbiology 37 (5), 1172-1185, 2000
1502000
Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus
J Tovar, S Wilkinson, JC Mottram, AH Fairlamb
Molecular microbiology 29 (2), 653-660, 1998
1491998
Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation
BS Hall, SR Wilkinson
Antimicrobial agents and chemotherapy 56 (1), 115-123, 2012
1382012
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification
F Irigoín, L Cibils, MA Comini, SR Wilkinson, L Flohé, R Radi
Free Radical Biology and Medicine 45 (6), 733-742, 2008
1382008
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin
SR Wilkinson, DJ Meyer, MC Taylor, EV Bromley, MA Miles, JM Kelly
Journal of Biological Chemistry 277 (19), 17062-17071, 2002
1382002
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum
SR Wilkinson, SO Obado, IL Mauricio, JM Kelly
Proceedings of the National Academy of Sciences 99 (21), 13453-13458, 2002
1352002
Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-β from Alzheimer disease
CJ Sarell, SR Wilkinson, JH Viles
Journal of biological chemistry 285 (53), 41533-41540, 2010
1332010
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression
L Piacenza, F Irigoín, MN Alvarez, G Peluffo, MC Taylor, JM Kelly, ...
Biochemical Journal 403 (2), 323-334, 2007
1332007
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage-and endogenously-derived peroxynitrite
L Piacenza, G Peluffo, MN Alvarez, JM Kelly, SR Wilkinson, R Radi
Biochemical Journal 410 (2), 359-368, 2008
1162008
RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the African trypanosome
SR Wilkinson, D Horn, SR Prathalingam, JM Kelly
Journal of Biological Chemistry 278 (34), 31640-31646, 2003
1152003
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.
SR Wilkinson, C Bot, J Kelly, B Hall
Current Topics in Medicinal Chemistry 11, 2072-2084, 2011
912011
Characterization of spo0A homologues in diverse Bacillus and Clostridium species identifies a probable DNA‐binding domain
DP Brown, L Ganova‐Raeva, BD Green, SR Wilkinson, M Young, ...
Molecular microbiology 14 (3), 411-426, 1994
871994
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei
SR Wilkinson, SR Prathalingam, MC Taylor, A Ahmed, D Horn, JM Kelly
Free Radical Biology and Medicine 40 (2), 198-209, 2006
852006
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the …
SR Wilkinson, MC Taylor, S Touitha, IL Mauricio, DJ Meyer, JM Kelly
Biochemical Journal 364 (3), 787-794, 2002
722002
Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity
SR WILKINSON, DJ MEYER, JM KELLY
Biochemical Journal 352 (3), 755-761, 2000
712000
Novel 3-Nitro-1H-1,2,4-triazole-Based Amides and Sulfonamides as Potential Antitrypanosomal Agents
MV Papadopoulou, WD Bloomer, HS Rosenzweig, E Chatelain, M Kaiser, ...
Journal of medicinal chemistry 55 (11), 5554-5565, 2012
672012
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