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Mark Searcey
Mark Searcey
Verified email at uea.ac.uk
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Year
Active targeting of gold nanoparticles as cancer therapeutics
ZR Goddard, MJ Marín, DA Russell, M Searcey
Chemical Society Reviews 49 (23), 8774-8789, 2020
1672020
Design, synthesis, and evaluation of an α-helix mimetic library targeting protein− protein interactions
A Shaginian, LR Whitby, S Hong, I Hwang, B Farooqi, M Searcey, J Chen, ...
Journal of the American Chemical Society 131 (15), 5564-5572, 2009
1662009
Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction
R Steel, J Cowan, E Payerne, MA O'Connell, M Searcey
ACS medicinal chemistry letters 3 (5), 407-410, 2012
1332012
Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies
S Dawson, JP Malkinson, D Paumier, M Searcey
Natural product reports 24 (1), 109-126, 2007
1192007
Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride
DL Boger, CW Boyce, RM Garbaccio, M Searcey
Tetrahedron letters 39 (16), 2227-2230, 1998
651998
Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties
B Bertrand, J Fernandez-Cestau, J Angulo, MMD Cominetti, ZAE Waller, ...
Inorganic Chemistry 56 (10), 5728-5740, 2017
622017
Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products
N Ghosh, HM Sheldrake, M Searcey, K Pors
Current topics in medicinal chemistry 9 (16), 1494-1524, 2009
622009
Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked‐X Four‐Way Junction by a Small Molecule
AL Brogden, NH Hopcroft, M Searcey, CJ Cardin
Angewandte Chemie International Edition 46 (21), 3850-3854, 2007
602007
Synthesis of distamycin A polyamides targeting G-quadruplex DNA
MJB Moore, F Cuenca, M Searcey, S Neidle
Organic & Biomolecular Chemistry 4 (18), 3479-3488, 2006
592006
Duocarmycins-natures prodrugs?
M Searcey
Current pharmaceutical design 8 (15), 1375-1389, 2002
582002
Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives.
M Searcey, S McClean, B Madden, AT McGown, LP Wakelin
Anti-cancer drug design 13 (8), 837-855, 1998
561998
A polyclonal antibody preparation with Michaelian catalytic properties
G Gallacher, CS Jackson, M Searcey, GT Badman, R Goel, CM Topham, ...
Biochemical Journal 279 (3), 871-881, 1991
561991
The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction
RC Clark, SY Lee, M Searcey, DL Boger
Natural product reports 26 (4), 465-477, 2009
542009
Total synthesis and comparative evaluation of luzopeptin A− C and quinoxapeptin A− C
DL Boger, MW Ledeboer, M Kume, M Searcey, Q Jin
Journal of the American Chemical Society 121 (49), 11375-11383, 1999
541999
Critical role of the linking amide in CC-1065 and the duocarmycins: implications on the source of DNA alkylation catalysis
DL Boger, A Santillán, M Searcey, Q Jin
Journal of the American Chemical Society 120 (45), 11554-11557, 1998
541998
Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder
M Sutherland, JH Gill, PM Loadman, JP Laye, HM Sheldrake, ...
Molecular cancer therapeutics 12 (1), 27-37, 2013
522013
A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators
PG Tsoungas, M Searcey
Tetrahedron Letters 42 (37), 6589-6592, 2001
522001
Polyclonal antibody-catalysed amide hydrolysis
G Gallacher, M Searcey, CS Jackson, K Brocklehurst
Biochemical Journal 284 (3), 675-680, 1992
521992
Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides
K Pors, SD Shnyder, PH Teesdale-Spittle, JA Hartley, M Zloh, M Searcey, ...
Journal of medicinal chemistry 49 (24), 7013-7023, 2006
492006
X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d (CGTACG) 2 molecules by a bis (9-aminoacridine-4-carboxamide) derivative
NH Hopcroft, AL Brogden, M Searcey, CJ Cardin
Nucleic acids research 34 (22), 6663-6672, 2006
472006
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