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Patrick A. Eyers
Patrick A. Eyers
Head of Biochemistry, Cell & Systems Biology, University of Liverpool. CSO Sulantrix Ltd
Verified email at liverpool.ac.uk - Homepage
Title
Cited by
Cited by
Year
Drug repurposing: progress, challenges and recommendations
S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ...
Nature reviews Drug discovery 18 (1), 41-58, 2019
35372019
A novel mechanism for activation of the protein kinase Aurora A
PA Eyers, E Erikson, LG Chen, JL Maller
Current Biology 13 (8), 691-697, 2003
4412003
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
PA Eyers, M Craxton, N Morricel, P Cohen, M Goedert
Chemistry & biology 5 (6), 321-328, 1998
3941998
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway
P Kovarik, D Stoiber, PA Eyers, R Menghini, A Neininger, M Gaestel, ...
Proceedings of the National Academy of Sciences 96 (24), 13956-13961, 1999
3511999
Validating Aurora B as an anti-cancer drug target
F Girdler, KE Gascoigne, PA Eyers, S Hartmuth, C Crafter, KM Foote, ...
Journal of cell science 119 (17), 3664-3675, 2006
3502006
Paradoxical activation of Raf by a novel Raf inhibitor
CA Hall-Jackson, PA Eyers, P Cohen, M Goedert, FT Boyle, N Hewitt, ...
Chemistry & biology 6 (8), 559-568, 1999
3001999
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ...
Biochemical Journal 457 (2), 323-334, 2014
2732014
Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease
PA Eyers, K Keeshan, N Kannan
Trends in cell biology 27 (4), 284-298, 2017
2182017
Local protein kinase A action proceeds through intact holoenzymes
FD Smith, JL Esseltine, PJ Nygren, D Veesler, DP Byrne, M Vonderach, ...
Science 356 (6344), 1288-1293, 2017
1962017
A framework for identification of actionable cancer genome dependencies in small cell lung cancer
ML Sos, F Dietlein, M Peifer, J Schöttle, H Balke-Want, C Müller, M Koker, ...
Proceedings of the National Academy of Sciences 109 (42), 17034-17039, 2012
1932012
Day of the dead: pseudokinases and pseudophosphatases in physiology and disease
V Reiterer, PA Eyers, H Farhan
Trends in cell biology 24 (9), 489-505, 2014
1892014
New perspectives, opportunities, and challenges in exploring the human protein kinome
LJ Wilson, A Linley, DE Hammond, FE Hood, JM Coulson, DJ MacEwan, ...
Cancer research 78 (1), 15-29, 2018
1682018
Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation
G Hardman, S Perkins, PJ Brownridge, CJ Clarke, DP Byrne, ...
The EMBO journal 38 (21), e100847, 2019
163*2019
Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography
CE Haydon, PA Eyers, LD Aveline-Wolf, KA Resing, JL Maller, NG Ahn
Molecular & Cellular Proteomics 2 (10), 1055-1067, 2003
1622003
Regulation of Xenopus Aurora A activation by TPX2
PA Eyers, JL Maller
Journal of Biological Chemistry 279 (10), 9008-9015, 2004
1602004
VX-680 inhibits Aurora A and Aurora B kinase activity in human cells
RK Tyler, N Shpiro, R Marquez, PA Eyers
Cell cycle 6 (22), 2846-2854, 2007
1352007
Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580
PA Eyers, P Van Den Ijssel, RA Quinlan, M Goedert, P Cohen
FEBS letters 451 (2), 191-196, 1999
1331999
Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237
DA Sloane, MZ Trikic, MLH Chu, MBAC Lamers, CS Mason, I Mueller, ...
ACS chemical biology 5 (6), 563-576, 2010
1232010
A single sulfatase is required to access colonic mucin by a gut bacterium
AS Luis, C Jin, GV Pereira, RWP Glowacki, SR Gugel, S Singh, DP Byrne, ...
Nature 598 (7880), 332-337, 2021
1172021
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
B Meyer, J Chiaravalli, S Gellenoncourt, P Brownridge, DP Bryne, LA Daly, ...
Nature communications 12 (1), 5553, 2021
103*2021
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