| In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors J Hao, JN Ho, JA Lewis, KA Karim, RN Daniels, PR Gentry, CR Hopkins, ... ACS chemical biology 5 (2), 245-253, 2010 | 435 | 2010 |
| Drugs for allosteric sites on receptors CJ Wenthur, PR Gentry, TP Mathews, CW Lindsley Annual review of pharmacology and toxicology 54, 165-184, 2014 | 265 | 2014 |
| Novel allosteric modulators of G protein-coupled receptors PR Gentry, PM Sexton, A Christopoulos Journal of Biological Chemistry 290 (32), 19478-19488, 2015 | 214 | 2015 |
| Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats AE Brady, CK Jones, TM Bridges, JP Kennedy, AD Thompson, ... Journal of Pharmacology and Experimental Therapeutics 327 (3), 941-953, 2008 | 207 | 2008 |
| Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl … TM Bridges, JE Marlo, CM Niswender, CK Jones, SB Jadhav, PR Gentry, ... Journal of medicinal chemistry 52 (11), 3445-3448, 2009 | 125 | 2009 |
| M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location DJ Foster, PR Gentry, JE Lizardi-Ortiz, TM Bridges, MR Wood, ... Journal of Neuroscience 34 (9), 3253-3262, 2014 | 86 | 2014 |
| Discovery of the First M5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1 … PR Gentry, M Kokubo, TM Bridges, NR Kett, JM Harp, HP Cho, E Smith, ... Journal of medicinal chemistry 56 (22), 9351-9355, 2013 | 71 | 2013 |
| Crystal structure of the M5 muscarinic acetylcholine receptor Z Vuckovic, PR Gentry, AE Berizzi, K Hirata, S Varghese, G Thompson, ... Proceedings of the National Academy of Sciences 116 (51), 26001-26007, 2019 | 70 | 2019 |
| Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM TM Bridges, JP Kennedy, MJ Noetzel, ML Breininger, PR Gentry, PJ Conn, ... Bioorganic & medicinal chemistry letters 20 (6), 1972-1975, 2010 | 53 | 2010 |
| Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM TM Bridges, JP Kennedy, HP Cho, ML Breininger, PR Gentry, CR Hopkins, ... Bioorganic & medicinal chemistry letters 20 (2), 558-562, 2010 | 49 | 2010 |
| Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties TM Bridges, AE Brady, JP Kennedy, RN Daniels, NR Miller, K Kim, ... Bioorganic & medicinal chemistry letters 18 (20), 5439-5442, 2008 | 47 | 2008 |
| Synthesis and structure–activity relationships of allosteric potentiators of the M4 muscarinic acetylcholine receptor JP Kennedy, TM Bridges, PR Gentry, JT Brogan, AS Kane, CK Jones, ... ChemMedChem 4 (10), 1600, 2009 | 43 | 2009 |
| Discovery of (S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): A Novel, CNS … LC Morris, KD Nance, PR Gentry, EL Days, CD Weaver, CM Niswender, ... Journal of Medicinal Chemistry 57 (23), 10192-10197, 2014 | 38 | 2014 |
| Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) R Williams, KA Johnson, PR Gentry, CM Niswender, CD Weaver, ... Bioorganic & medicinal chemistry letters 19 (17), 4967-4970, 2009 | 38 | 2009 |
| Molecular mechanisms of action of M5 muscarinic acetylcholine receptor allosteric modulators AE Berizzi, PR Gentry, P Rueda, S Den Hoedt, PM Sexton, CJ Langmead, ... Molecular pharmacology 90 (4), 427-436, 2016 | 33 | 2016 |
| Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)‐Selective M5‐Orthosteric Antagonist, VU0488130 (ML381): A … PR Gentry, M Kokubo, TM Bridges, HP Cho, E Smith, P Chase, ... ChemMedChem 9 (8), 1677-1682, 2014 | 33 | 2014 |
| Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule MS Poslusney, BJ Melancon, PR Gentry, DJ Sheffler, TM Bridges, ... Bioorganic & medicinal chemistry letters 23 (6), 1860-1864, 2013 | 31 | 2013 |
| Synthesis and SAR of novel, 4-(phenylsulfamoyl) phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS) DW Engers, PR Gentry, R Williams, JD Bolinger, CD Weaver, UN Menon, ... Bioorganic & medicinal chemistry letters 20 (17), 5175-5178, 2010 | 31 | 2010 |
| Development of a Highly Potent, Novel M5 Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2 … PR Gentry, M Kokubo, TM Bridges, MJ Noetzel, HP Cho, A Lamsal, ... Journal of medicinal chemistry 57 (18), 7804-7810, 2014 | 29 | 2014 |
| Discovery of ML326: The first sub-micromolar, selective M5 PAM PR Gentry, TM Bridges, A Lamsal, PN Vinson, E Smith, P Chase, ... Bioorganic & medicinal chemistry letters 23 (10), 2996-3000, 2013 | 27 | 2013 |
Craig LindsleyVanderbilt UniversityVerified email at vanderbilt.edu
