Machine learning meets continuous flow chemistry: Automated optimization towards the Pareto front of multiple objectives AM Schweidtmann, AD Clayton, N Holmes, E Bradford, RA Bourne, ... Chemical Engineering Journal 352, 277-282, 2018 | 299 | 2018 |
Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors N Holmes, GR Akien, RJD Savage, C Stanetty, IR Baxendale, AJ Blacker, ... Reaction Chemistry & Engineering 1 (1), 96-100, 2016 | 132 | 2016 |
Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor N Holmes, GR Akien, AJ Blacker, RL Woodward, RE Meadows, ... Reaction Chemistry & Engineering 1 (4), 366-371, 2016 | 116 | 2016 |
Rapid multistep kinetic model generation from transient flow data CA Hone, N Holmes, GR Akien, RA Bourne, FL Muller Reaction chemistry & engineering 2 (2), 103-108, 2017 | 93 | 2017 |
Enhanced process development using automated continuous reactors by self-optimisation algorithms and statistical empirical modelling MI Jeraal, N Holmes, GR Akien, RA Bourne Tetrahedron 74 (25), 3158-3164, 2018 | 44 | 2018 |
Efficient and selective oxidation of sulfides in batch and continuous flow using styrene-based polymer immobilised ionic liquid phase supported peroxotungstates S Doherty, JG Knight, MA Carroll, AR Clemmet, JR Ellison, T Backhouse, ... RSC advances 6 (77), 73118-73131, 2016 | 30 | 2016 |
Analysis and Optimisation of Continuous Processes N HOLMES, RA BOURNE Chemical Processes for a Sustainable Future, 28, 2014 | 2 | 2014 |
Self-Optimisation of Automated Continuous Reactors N Holmes University of Leeds, 2017 | | 2017 |
Self-optimizing flow reactors in pharmaceutical development for rapid process optimization N Holmes, R Bourne, J Blacker, R Meadows, R Woodward ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016 | | 2016 |