Sebastian Hutchinson
Sebastian Hutchinson
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VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes
L Glover, S Hutchinson, S Alsford, D Horn
Proceedings of the National Academy of Sciences 113 (26), 7225-7230, 2016
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control
L Glover, S Hutchinson, S Alsford, R McCulloch, MC Field, D Horn
Cellular microbiology 15 (12), 1984-1993, 2013
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes
L Glover, S Alsford, N Baker, DJ Turner, A Sanchez-Flores, S Hutchinson, ...
nature protocols 10 (1), 106-133, 2015
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes
N Baker, G Hamilton, JM Wilkes, S Hutchinson, MP Barrett, D Horn
Proceedings of the National Academy of Sciences 112 (29), 9112-9117, 2015
Biallelic mutations in LRRC56, encoding a protein associated with intraflagellar transport, cause mucociliary clearance and laterality defects
S Bonnefoy, CM Watson, KD Kernohan, M Lemos, S Hutchinson, ...
The American Journal of Human Genetics 103 (5), 727-739, 2018
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling
J Thomas, N Baker, S Hutchinson, C Dominicus, A Trenaman, L Glover, ...
PLoS neglected tropical diseases 12 (11), e0006980, 2018
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
J Faria, L Glover, S Hutchinson, C Boehm, MC Field, D Horn
Nature communications 10 (1), 1-14, 2019
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
N Zhang, M Zoltner, KF Leung, P Scullion, S Hutchinson, RC Del Pino, ...
PLoS pathogens 14 (2), e1006850, 2018
High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes
S Hutchinson, L Glover, D Horn
BMC Genomics, 2016
CRISPR in parasitology: not exactly cut and dried!
JM Bryant, S Baumgarten, L Glover, S Hutchinson, N Rachidi
Trends in parasitology 35 (6), 409-422, 2019
Chemogenomic profiling of antileishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei
CF Collett, C Kitson, N Baker, HB Steele-Stallard, MV Santrot, ...
Antimicrobial agents and chemotherapy 63 (8), e00795-19, 2019
A post-transcriptional respiratome regulon in trypanosomes
A Trenaman, L Glover, S Hutchinson, D Horn
Nucleic acids research 47 (13), 7063-7077, 2019
Flagellar incorporation of proteins follows at least two different routes in trypanosomes
L Vincensini, T Blisnick, E Bertiaux, S Hutchinson, C Georgikou, CP Ooi, ...
Biology of the Cell 110 (2), 33-47, 2018
Escaping the immune system by DNA repair and recombination in African trypanosomes
N Sima, EJ McLaughlin, S Hutchinson, L Glover
Open biology 9 (11), 190182, 2019
Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes
J Faria, V Luzak, LSM Müller, BG Brink, S Hutchinson, L Glover, D Horn, ...
Nature Microbiology 6 (3), 289-300, 2021
Antigenic variation by switching inter-chromosomal interactions with an RNA splicing locus in trypanosomes
J Faria, V Luzak, LSM Müller, BG Brink, S Hutchinson, L Glover, D Horn, ...
BioRxiv, 2020
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes
AK Mehnert, M Prorocic, A Dujeancourt-Henry, S Hutchinson, ...
Nucleic Acids Research, 2021
The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands.
S Hutchinson, S Foulon, A Crouzols, R Menafra, B Rotureau, AD Griffiths, ...
bioRxiv, 2021
Forward Genetics in African Trypanosomes
S Hutchinson, L Glover
Trypanosomatids, 339-352, 2020
Biallelic Mutations in LRRC56, encoding a protein associated with intraflagellar transport, causes defects in mucociliary clearance and laterality
EG Sheridan, S Bonnefoy, CM Watson, KD Kernohan, M Lemos, ...
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