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Scott P France
Scott P France
Verified email at merck.com
Title
Cited by
Cited by
Year
Constructing biocatalytic cascades: in vitro and in vivo approaches to de novo multi-enzyme pathways
SP France, LJ Hepworth, NJ Turner, SL Flitsch
Acs Catalysis 7 (1), 710-724, 2017
3592017
A reductive aminase from Aspergillus oryzae
GA Aleku, SP France, H Man, J Mangas-Sanchez, SL Montgomery, ...
Nature Chemistry 9 (10), 961-969, 2017
3222017
Biocatalysis
EL Bell, W Finnigan, SP France, AP Green, MA Hayes, LJ Hepworth, ...
Nature Reviews Methods Primers 1 (1), 46, 2021
3112021
Imine reductases (IREDs)
J Mangas-Sanchez, SP France, SL Montgomery, GA Aleku, H Man, ...
Current opinion in chemical biology 37, 19-25, 2017
2212017
One-pot cascade synthesis of mono-and disubstituted piperidines and pyrrolidines using carboxylic acid reductase (CAR), ω-transaminase (ω-TA), and imine reductase (IRED …
SP France, S Hussain, AM Hill, LJ Hepworth, RM Howard, KR Mulholland, ...
Acs Catalysis 6 (6), 3753-3759, 2016
2072016
An (R)‐Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines
S Hussain, F Leipold, H Man, E Wells, SP France, KR Mulholland, ...
ChemCatChem 7 (4), 579-583, 2015
1642015
Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis
GA Aleku, H Man, SP France, F Leipold, S Hussain, L Toca-Gonzalez, ...
Acs Catalysis 6 (6), 3880-3889, 2016
1172016
Enzyme cascades in whole cells for the synthesis of chiral cyclic amines
LJ Hepworth, SP France, S Hussain, P Both, NJ Turner, SL Flitsch
ACS Catalysis 7 (4), 2920-2925, 2017
972017
Identification of novel bacterial members of the imine reductase enzyme family that perform reductive amination
SP France, RM Howard, J Steflik, NJ Weise, J Mangas‐Sanchez, ...
ChemCatChem 10 (3), 510-514, 2018
942018
A mechanism for reductive amination catalyzed by fungal reductive aminases
M Sharma, J Mangas-Sanchez, SP France, GA Aleku, SL Montgomery, ...
ACS Catalysis 8 (12), 11534-11541, 2018
852018
Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines
SP France, GA Aleku, M Sharma, J Mangas‐Sanchez, RM Howard, ...
Angewandte Chemie International Edition 56 (49), 15589-15593, 2017
722017
Kinetic resolution and deracemization of racemic amines using a reductive aminase
GA Aleku, J Mangas‐Sanchez, J Citoler, SP France, SL Montgomery, ...
ChemCatChem 10 (3), 515-519, 2018
542018
One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles
TW Thorpe, SP France, S Hussain, JR Marshall, W Zawodny, ...
Journal of the American Chemical Society 141 (49), 19208-19213, 2019
482019
Carboxylic acid reductases (CARs): An industrial perspective
SR Derrington, NJ Turner, SP France
Journal of biotechnology 304, 78-88, 2019
482019
Imine reductases, reductive aminases, and amine oxidases for the synthesis of chiral amines: discovery, characterization, and synthetic applications
SC Cosgrove, A Brzezniak, SP France, JI Ramsden, J Mangas-Sanchez, ...
Methods in enzymology 608, 131-149, 2018
422018
Synthesis of 2,5‐Disubstituted Pyrrolidine Alkaloids via A One‐Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts
BZ Costa, JL Galman, I Slabu, SP France, AJ Marsaioli, NJ Turner
ChemCatChem 10 (20), 4733-4738, 2018
362018
PF-07059013: a noncovalent modulator of hemoglobin for treatment of sickle cell disease
A Gopalsamy, AE Aulabaugh, A Barakat, KC Beaumont, S Cabral, ...
Journal of Medicinal Chemistry 64 (1), 326-342, 2020
312020
Synthetic approaches to the new drugs approved during 2019
AC Flick, CA Leverett, HX Ding, E McInturff, SJ Fink, S Mahapatra, ...
Journal of Medicinal Chemistry 64 (7), 3604-3657, 2021
282021
Inducing achiral aliphatic oligoureas to fold into helical conformations
R Wechsel, J Maury, J Fremaux, SP France, G Guichard, J Clayden
Chemical Communications 50 (95), 15006-15009, 2014
262014
The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development
SP France, RD Lewis, CA Martinez
JACS Au 3 (3), 715-735, 2023
252023
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