| Enhanced nonenzymatic RNA copying with 2-aminoimidazole activated nucleotides L Li, N Prywes, CP Tam, DK O’flaherty, VS Lelyveld, EC Izgu, A Pal, ... Journal of the American Chemical Society 139 (5), 1810-1813, 2017 | 158 | 2017 |
| Copying of mixed-sequence RNA templates inside model protocells DK O’Flaherty, NP Kamat, FN Mirza, L Li, N Prywes, JW Szostak Journal of the American Chemical Society 140 (15), 5171-5178, 2018 | 86 | 2018 |
| A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides, and 2′-deoxynucleotides SC Kim, L Zhou, W Zhang, DK O’Flaherty, V Rondo-Brovetto, JW Szostak Journal of the American Chemical Society 142 (5), 2317-2326, 2020 | 54 | 2020 |
| Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA SC Kim, DK O’Flaherty, L Zhou, VS Lelyveld, JW Szostak Proceedings of the National Academy of Sciences 115 (52), 13318-13323, 2018 | 48 | 2018 |
| Non-enzymatic primer extension with strand displacement L Zhou, SC Kim, KH Ho, DK O'Flaherty, C Giurgiu, TH Wright, JW Szostak Elife 8, e51888, 2019 | 47 | 2019 |
| Template‐directed copying of RNA by non‐enzymatic ligation L Zhou, DK O'Flaherty, JW Szostak Angewandte Chemie 132 (36), 15812-15817, 2020 | 45 | 2020 |
| Nonenzymatic template-directed synthesis of mixed-sequence 3′-NP-DNA up to 25 nucleotides long inside model protocells DK O’Flaherty, L Zhou, JW Szostak Journal of the American Chemical Society 141 (26), 10481-10488, 2019 | 34 | 2019 |
| Assembly of a ribozyme ligase from short oligomers by nonenzymatic ligation L Zhou, DK O’Flaherty, JW Szostak Journal of the American Chemical Society 142 (37), 15961-15965, 2020 | 32 | 2020 |
| Thermally driven membrane phase transitions enable content reshuffling in primitive cells R Rubio-Sánchez, DK O’Flaherty, A Wang, F Coscia, G Petris, ... Journal of the American Chemical Society 143 (40), 16589-16598, 2021 | 30 | 2021 |
| Steady‐State Kinetic Analysis of DNA Polymerase Single‐Nucleotide Incorporation Products DK O'Flaherty, FP Guengerich Current Protocols in Nucleic Acid Chemistry 59 (1), 7.21. 1-7.21. 13, 2014 | 30 | 2014 |
| The emergence of RNA from the heterogeneous products of prebiotic nucleotide synthesis SC Kim, DK O’Flaherty, C Giurgiu, L Zhou, JW Szostak Journal of the American Chemical Society 143 (9), 3267-3279, 2021 | 26 | 2021 |
| O 4-Alkyl-2′-deoxythymidine cross-linked DNA to probe recognition and repair by O 6-alkylguanine DNA alkyltransferases FP McManus, DK O'Flaherty, AM Noronha, CJ Wilds Organic & Biomolecular Chemistry 10 (35), 7078-7090, 2012 | 26 | 2012 |
| A mechanistic explanation for the regioselectivity of nonenzymatic RNA primer extension C Giurgiu, L Li, DK O’Flaherty, CP Tam, JW Szostak Journal of the American Chemical Society 139 (46), 16741-16747, 2017 | 23 | 2017 |
| Prebiotically plausible “patching” of RNA backbone cleavage through a 3′–5′ pyrophosphate linkage TH Wright, C Giurgiu, W Zhang, A Radakovic, DK O’Flaherty, L Zhou, ... Journal of the American Chemical Society 141 (45), 18104-18112, 2019 | 20 | 2019 |
| Synthesis, Characterization, and Repair of a Flexible O6‐2′‐Deoxyguanosine‐alkylene‐O6‐2′‐deoxyguanosine Intrastrand Cross‐Link DK O'Flaherty, CJ Wilds Chemistry–A European Journal 21 (29), 10522-10529, 2015 | 15 | 2015 |
| A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying C Giurgiu, TH Wright, DK O'Flaherty, JW Szostak Angewandte Chemie International Edition 57 (31), 9844-9848, 2018 | 13 | 2018 |
| siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial … M Akabane-Nakata, ND Erande, P Kumar, R Degaonkar, JA Gilbert, J Qin, ... Nucleic Acids Research 49 (5), 2435-2449, 2021 | 11 | 2021 |
| Lesion orientation of O 4-alkylthymidine influences replication by human DNA polymerase η DK O'Flaherty, A Patra, Y Su, FP Guengerich, M Egli, CJ Wilds Chemical science 7 (8), 4896-4904, 2016 | 10 | 2016 |
| DNA polymerase activity on synthetic N3′→ P5′ phosphoramidate DNA templates VS Lelyveld, DK O’Flaherty, L Zhou, EC Izgu, JW Szostak Nucleic acids research 47 (17), 8941-8949, 2019 | 9 | 2019 |
| O6‐Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross‐Linked DNA is Influenced by the Internucleotide Linkage DK O'Flaherty, CJ Wilds Chemistry–An Asian Journal 11 (4), 576-583, 2016 | 8 | 2016 |
