| Metal ions as modulators of protein conformation and misfolding in neurodegeneration SS Leal, HM Botelho, CM Gomes Coordination Chemistry Reviews 256 (19-20), 2253-2270, 2012 | 172 | 2012 |
| Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability SS Leal, CM Gomes Frontiers in cellular neuroscience 9, 225, 2015 | 86 | 2015 |
| Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B (P56S) neurotoxicity SH Kim, SS Leal, DB Halevy, CM Gomes, S Lev Journal of biological chemistry 285 (18), 13839-13849, 2010 | 83 | 2010 |
| Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)? SS Leal, I Cardoso, JS Valentine, CM Gomes Journal of Biological Chemistry 288 (35), 25219-25228, 2013 | 71 | 2013 |
| The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre T Urich, TM Bandeiras, SS Leal, R Rachel, T Albrecht, P Zimmermann, ... Biochemical Journal 381 (1), 137-146, 2004 | 70 | 2004 |
| The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation JS Cristóvão, VK Morris, I Cardoso, SS Leal, J Martínez, HM Botelho, ... Science advances 4 (6), eaaq1702, 2018 | 65 | 2018 |
| Characterization of plasma labile heme in hemolytic conditions Z Gouveia, AR Carlos, X Yuan, F Aires‐da‐Silva, R Stocker, GJ Maghzal, ... The FEBS journal 284 (19), 3278-3301, 2017 | 62 | 2017 |
| S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation HM Botelho, SS Leal, I Cardoso, K Yanamandra, LA Morozova-Roche, ... Journal of Biological Chemistry 287 (50), 42233-42242, 2012 | 43 | 2012 |
| Studies of the molten globule state of ferredoxin: structural characterization and implications on protein folding and iron–sulfur center assembly SS Leal, CM Gomes Proteins: Structure, Function, and Bioinformatics 68 (3), 606-616, 2007 | 43 | 2007 |
| Aberrant zinc binding to immature conformers of metal-free copper–zinc superoxide dismutase triggers amorphous aggregation SS Leal, JS Cristóvão, A Biesemeier, I Cardoso, CM Gomes Metallomics 7 (2), 333-346, 2015 | 40 | 2015 |
| Lactoperoxidase folding and catalysis relies on the stabilization of the α-helix rich core domain: A thermal unfolding study B Boscolo, SS Leal, EM Ghibaudi, CM Gomes Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (9), 1164-1172, 2007 | 39 | 2007 |
| Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins SB Carvalho, HM Botelho, SS Leal, I Cardoso, G Fritz, CM Gomes PLoS One 8 (10), e76629, 2013 | 32 | 2013 |
| Studies on the degradation pathway of iron-sulfur centers during unfolding of a hyperstable ferredoxin: cluster dissociation, iron release and protein stability SS Leal, M Teixeira, CM Gomes JBIC Journal of Biological Inorganic Chemistry 9, 987-996, 2004 | 30 | 2004 |
| The prominent conformational plasticity of lactoperoxidase: a chemical and pH stability analysis B Boscolo, SS Leal, CA Salgueiro, EM Ghibaudi, CM Gomes Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (7), 1041-1048, 2009 | 24 | 2009 |
| A spectroscopic study of the temperature induced modifications on ferredoxin folding and iron− sulfur moieties S Todorovic, SS Leal, CA Salgueiro, I Zebger, P Hildebrandt, DH Murgida, ... Biochemistry 46 (37), 10733-10738, 2007 | 21 | 2007 |
| Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1) SG Estácio, SS Leal, JS Cristóvão, PFN Faísca, CM Gomes Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854 (2), 118-126, 2015 | 19 | 2015 |
| Natural domain design: enhanced thermal stability of a zinc-lacking ferredoxin isoform shows that a hydrophobic core efficiently replaces the structural metal site R Rocha, SS Leal, VH Teixeira, M Regalla, H Huber, AM Baptista, ... Biochemistry 45 (34), 10376-10384, 2006 | 19 | 2006 |
| Crystallographic analysis of the intact metal centres [3Fe–4S] 1+/0 and [4Fe–4S] 2+/1+ in a Zn2+-containing ferredoxin C Frazão, D Aragão, R Coelho, SS Leal, CM Gomes, M Teixeira, ... FEBS letters 582 (5), 763-767, 2008 | 13 | 2008 |
| Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins SS Leal, CM Gomes Walter de Gruyter 386 (12), 1295-1300, 2005 | 12 | 2005 |
| Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor M Vieira, SS Leal, CM Gomes, MJ Saraiva Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (4), 797-804, 2016 | 11 | 2016 |
Cláudio M. GomesFaculty of Sciences University of Lisbon, BioISI and Department of Chemistry and BiochemistryVerified email at fc.ul.pt
