Heather Christofk
Heather Christofk
Associate Professor of Molecular and Medical Pharmacology and Biological Chemistry, UCLA
Verified email at mednet.ucla.edu - Homepage
Cited by
Cited by
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
HR Christofk, MG Vander Heiden, MH Harris, A Ramanathan, ...
Nature 452 (7184), 230-233, 2008
Pyruvate kinase M2 is a phosphotyrosine-binding protein
HR Christofk, MG Vander Heiden, N Wu, JM Asara, LC Cantley
Nature 452 (7184), 181-186, 2008
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
MG Vander Heiden, JW Locasale, KD Swanson, H Sharfi, GJ Heffron, ...
Science 329 (5998), 1492-1499, 2010
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
Metabolic state of glioma stem cells and nontumorigenic cells
E Vlashi, C Lagadec, L Vergnes, T Matsutani, K Masui, M Poulou, ...
Proceedings of the National Academy of Sciences 108 (38), 16062-16067, 2011
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
RM Chin, X Fu, MY Pai, L Vergnes, H Hwang, G Deng, S Diep, ...
Nature 510 (7505), 397-401, 2014
New aspects of the Warburg effect in cancer cell biology
SJ Bensinger, HR Christofk
Seminars in cell & developmental biology 23 (4), 352-361, 2012
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
AS Krall, S Xu, TG Graeber, D Braas, HR Christofk
Nature communications 7 (1), 1-13, 2016
A label‐free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen
JM Asara, HR Christofk, LM Freimark, LC Cantley
Proteomics 8 (5), 994-999, 2008
Identification of small molecule inhibitors of pyruvate kinase M2
MG Vander Heiden, HR Christofk, E Schuman, AO Subtelny, H Sharfi, ...
Biochemical pharmacology 79 (8), 1118-1124, 2010
Histone acetylation regulates intracellular pH
MA McBrian, IS Behbahan, R Ferrari, T Su, TW Huang, K Li, CS Hong, ...
Molecular cell 49 (2), 310-321, 2013
Glycolytic metabolism plays a functional role in regulating human pluripotent stem cell state
W Gu, X Gaeta, A Sahakyan, AB Chan, CS Hong, R Kim, D Braas, K Plath, ...
Cell stem cell 19 (4), 476-490, 2016
Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication
M Thai, NA Graham, D Braas, M Nehil, E Komisopoulou, SK Kurdistani, ...
Cell metabolism 19 (4), 694-701, 2014
2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling
X Fu, RM Chin, L Vergnes, H Hwang, G Deng, Y Xing, MY Pai, S Li, L Ta, ...
Cell metabolism 22 (3), 508-515, 2015
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
JC Schell, DR Wisidagama, C Bensard, H Zhao, P Wei, J Tanner, A Flores, ...
Nature cell biology 19 (9), 1027-1036, 2017
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity
KJ Williams, JP Argus, Y Zhu, MQ Wilks, BN Marbois, AG York, Y Kidani, ...
Cancer research 73 (9), 2850-2862, 2013
Doxycycline alters metabolism and proliferation of human cell lines
E Ahler, WJ Sullivan, A Cass, D Braas, AG York, SJ Bensinger, ...
PloS one 8 (5), e64561, 2013
MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
CS Hong, NA Graham, W Gu, CE Camacho, V Mah, EL Maresh, M Alavi, ...
Cell reports 14 (7), 1590-1601, 2016
Viral hijacking of cellular metabolism
SK Thaker, J Ch’ng, HR Christofk
BMC biology 17 (1), 1-15, 2019
Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy
CK Domigan, CM Warren, V Antanesian, K Happel, S Ziyad, S Lee, ...
Journal of cell science 128 (12), 2236-2248, 2015
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