Leonard Girnita
Leonard Girnita
MD, PhD, Associate Professor, Karolinska Institute
Verified email at ki.se - Homepage
TitleCited byYear
Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
A Girnita, L Girnita, F del Prete, A Bartolazzi, O Larsson, M Axelson
Cancer research 64 (1), 236-242, 2004
3522004
Role of insulin-like growth factor 1 receptor signalling in cancer
O Larsson, A Girnita, L Girnita
British journal of cancer 92 (12), 2097, 2005
2612005
Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target
C All-Ericsson, L Girnita, S Seregard, A Bartolazzi, MJ Jager, O Larsson
Investigative ophthalmology & visual science 43 (1), 1-8, 2002
2192002
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
L Girnita, A Girnita, O Larsson
Proceedings of the National Academy of Sciences 100 (14), 8247-8252, 2003
2162003
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells
T Strömberg, S Ekman, L Girnita, LY Dimberg, O Larsson, M Axelson, ...
Blood 107 (2), 669-678, 2006
1732006
The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 …
D Vasilcanu, A Girnita, L Girnita, R Vasilcanu, M Axelson, O Larsson
Oncogene 23 (47), 7854, 2004
1632004
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model
E Menu, H Jernberg-Wiklund, T Stromberg, H De Raeve, L Girnita, ...
Blood 107 (2), 655-660, 2006
1412006
β-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
L Girnita, SK Shenoy, B Sehat, R Vasilcanu, A Girnita, RJ Lefkowitz, ...
Journal of Biological Chemistry 280 (26), 24412-24419, 2005
1382005
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
A Girnita, C All-Ericsson, MA Economou, M Axelson, S Seregard, ...
Clinical cancer research 12 (4), 1383-1391, 2006
1192006
β-Arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression
L Girnita, SK Shenoy, B Sehat, R Vasilcanu, D Vasilcanu, A Girnita, ...
Journal of Biological Chemistry 282 (15), 11329-11338, 2007
1162007
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis
B Sehat, S Andersson, L Girnita, O Larsson
Cancer Research 68 (14), 5669-5677, 2008
1092008
Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact
L Girnita, A Girnita, B Brodin, Y Xie, G Nilsson, A Dricu, J Lundeberg, ...
Cancer research 60 (18), 5278-5283, 2000
1012000
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation
L Girnita, C Worrall, SI Takahashi, S Seregard, A Girnita
Cellular and molecular life sciences 71 (13), 2403-2427, 2014
912014
Expression of Insulin-Like Growth Factor-1 Receptor (IGF-1R) and p27Kip1 in Melanocyte Tumors: A Potential Regulatory Role of IGF-1 Pathway in Distribution of p27Kip1 between …
L Kanter-Lewensohn, A Dricu, L Girnita, J Wejde, O Larsson
Growth Factors 17 (3), 193-202, 2000
882000
Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma
J Åhlén, J Wejde, O Brosjö, A von Rosen, WH Weng, L Girnita, O Larsson, ...
Clinical cancer research 11 (1), 206-216, 2005
852005
c-Kit–dependent growth of uveal melanoma cells: a potential therapeutic target?
C All-Ericsson, L Girnita, A Müller-Brunotte, B Brodin, S Seregard, ...
Investigative ophthalmology & visual science 45 (7), 2075-2082, 2004
792004
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor
H Zheng, C Worrall, H Shen, T Issad, S Seregard, A Girnita, L Girnita
Proceedings of the National Academy of Sciences 109 (18), 7055-7060, 2012
742012
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and β-arrestin1
R Vasilcanu, D Vasilcanu, L Rosengren, N Natalishvili, B Sehat, S Yin, ...
Oncogene 27 (11), 1629, 2008
732008
Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor
A Girnita, H Zheng, A Grönberg, L Girnita, M Ståhle
Oncogene 31 (3), 352, 2012
682012
Role of ubiquitination in IGF-1 receptor signaling and degradation
B Sehat, S Andersson, R Vasilcanu, L Girnita, O Larsson
PloS one 2 (4), e340, 2007
672007
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