| The NAD metabolome—a key determinant of cancer cell biology A Chiarugi, C Dölle, R Felici, M Ziegler Nature Reviews Cancer 12 (11), 741-752, 2012 | 633 | 2012 |
| Poly (ADP-ribose) polymerase: killer or conspirator? The ‘suicide hypothesis’ revisited A Chiarugi Trends in pharmacological sciences 23 (3), 122-129, 2002 | 375 | 2002 |
| Delayed inflammation in rat meninges: implications for migraine pathophysiology U Reuter, H Bolay, I Jansen-Olesen, A Chiarugi, MS del Rio, ... Brain 124 (12), 2490-2502, 2001 | 375 | 2001 |
| BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia N Plesnila, S Zinkel, DA Le, S Amin-Hanjani, Y Wu, J Qiu, A Chiarugi, ... Proceedings of the National Academy of Sciences 98 (26), 15318-15323, 2001 | 321 | 2001 |
| Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain G Faraco, T Pancani, L Formentini, P Mascagni, G Fossati, F Leoni, ... Molecular pharmacology 70 (6), 1876-1884, 2006 | 285 | 2006 |
| Poly (ADP‐ribose) polymerase‐1 activity promotes NF‐κB‐driven transcription and microglial activation: implication for neurodegenerative disorders A Chiarugi, MA Moskowitz Journal of neurochemistry 85 (2), 306-317, 2003 | 271 | 2003 |
| High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo G Faraco, S Fossati, ME Bianchi, M Patrone, M Pedrazzi, B Sparatore, ... Journal of neurochemistry 103 (2), 590-603, 2007 | 268 | 2007 |
| The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension M Porcu, A Chiarugi Trends in pharmacological sciences 26 (2), 94-103, 2005 | 246 | 2005 |
| Nuclear factor‐κB as a molecular target for migraine therapy U Reuter, A Chiarugi, H Bolay, MA Moskowitz Annals of Neurology: Official Journal of the American Neurological …, 2002 | 236 | 2002 |
| Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool M Pittelli, L Formentini, G Faraco, A Lapucci, E Rapizzi, F Cialdai, ... Journal of Biological Chemistry 285 (44), 34106-34114, 2010 | 221 | 2010 |
| PARP-1--a perpetrator of apoptotic cell death? A Chiarugi, MA Moskowitz Science 297 (5579), 200-201, 2002 | 216 | 2002 |
| Opportunities for the repurposing of PARP inhibitors for the therapy of non‐oncological diseases NA Berger, VC Besson, AH Boulares, A Bürkle, A Chiarugi, RS Clark, ... British journal of pharmacology 175 (2), 192-222, 2018 | 196 | 2018 |
| Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities R Carpenedo, A Chiarugi, P Russi, G Lombardi, V Carlà, R Pellicciari, ... Neuroscience 61 (2), 237-244, 1994 | 194 | 1994 |
| Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism C Adembri, L Venturi, A Tani, A Chiarugi, E Gramigni, A Cozzi, T Pancani, ... The Journal of the American Society of Anesthesiologists 104 (1), 80-89, 2006 | 190 | 2006 |
| Poly (ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia F Moroni, E Meli, F Peruginelli, A Chiarugi, A Cozzi, R Picca, P Romagnoli, ... Cell Death & Differentiation 8 (9), 921-932, 2001 | 189 | 2001 |
| Nuclear poly (ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction G Cipriani, E Rapizzi, A Vannacci, R Rizzuto, F Moroni, A Chiarugi Journal of Biological Chemistry 280 (17), 17227-17234, 2005 | 177 | 2005 |
| Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl) alanine, a potent inhibitor of … R Pellicciari, B Natalini, G Costantino, MR Mahmoud, L Mattoli, ... Journal of medicinal chemistry 37 (5), 647-655, 1994 | 170 | 1994 |
| Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages A Chiarugi, M Calvani, E Meli, E Traggiai, F Moroni Journal of neuroimmunology 120 (1-2), 190-198, 2001 | 157 | 2001 |
| Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis M Pittelli, R Felici, V Pitozzi, L Giovannelli, E Bigagli, F Cialdai, G Romano, ... Molecular pharmacology 80 (6), 1136-1146, 2011 | 147 | 2011 |
| Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo G Faraco, M Pittelli, L Cavone, S Fossati, M Porcu, P Mascagni, G Fossati, ... Neurobiology of disease 36 (2), 269-279, 2009 | 146 | 2009 |
