| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain K Itoh, N Wakabayashi, Y Katoh, T Ishii, K Igarashi, JD Engel, ... Genes & development 13 (1), 76-86, 1999 | 3970 | 1999 |
| Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway TW Kensler, N Wakabayashi, S Biswal Annu. Rev. Pharmacol. Toxicol. 47, 89-116, 2007 | 3820 | 2007 |
| Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants AT Dinkova-Kostova, WD Holtzclaw, RN Cole, K Itoh, N Wakabayashi, ... Proceedings of the National Academy of Sciences 99 (18), 11908-11913, 2002 | 2260 | 2002 |
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ... Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004 | 1138 | 2004 |
| Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation N Wakabayashi, K Itoh, J Wakabayashi, H Motohashi, S Noda, ... Nature genetics 35 (3), 238-245, 2003 | 986 | 2003 |
| Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles K Itoh, N Wakabayashi, Y Katoh, T Ishii, T O'Connor, M Yamamoto Genes to cells 8 (4), 379-391, 2003 | 976 | 2003 |
| Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis D Malhotra, E Portales-Casamar, A Singh, S Srivastava, D Arenillas, ... Nucleic acids research 38 (17), 5718-5734, 2010 | 837 | 2010 |
| Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival MK Kwak, N Wakabayashi, K Itoh, H Motohashi, M Yamamoto, ... Journal of Biological Chemistry 278 (10), 8135-8145, 2003 | 802 | 2003 |
| The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice J Wakabayashi, Z Zhang, N Wakabayashi, Y Tamura, M Fukaya, ... Journal of Cell Biology 186 (6), 805-816, 2009 | 678 | 2009 |
| Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes MI Kang, A Kobayashi, N Wakabayashi, SG Kim, M Yamamoto Proceedings of the National Academy of Sciences 101 (7), 2046-2051, 2004 | 672 | 2004 |
| When NRF2 talks, who's listening? N Wakabayashi, SL Slocum, JJ Skoko, S Shin, TW Kensler Antioxidants & redox signaling 13 (11), 1649-1663, 2010 | 640 | 2010 |
| Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway MK Kwak, N Wakabayashi, JL Greenlaw, M Yamamoto, TW Kensler Molecular and cellular biology 23 (23), 8786-8794, 2003 | 574 | 2003 |
| Nrf2: friend or foe for chemoprevention? TW Kensler, N Wakabayashi Carcinogenesis 31 (1), 90-99, 2010 | 530 | 2010 |
| Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress CJ Harvey, RK Thimmulappa, A Singh, DJ Blake, G Ling, N Wakabayashi, ... Free Radical Biology and Medicine 46 (4), 443-453, 2009 | 515 | 2009 |
| Regulatory mechanisms of cellular response to oxidative stress K Itoh, T Ishii, N Wakabayashi, M Yamamoto Free radical research 31 (4), 319-324, 1999 | 424 | 1999 |
| Chemoprevention through the Keap1–Nrf2 signaling pathway by phase 2 enzyme inducers MK Kwak, N Wakabayashi, TW Kensler Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 555 (1 …, 2004 | 370 | 2004 |
| NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis S Shin, N Wakabayashi, V Misra, S Biswal, GH Lee, ES Agoston, ... Molecular and cellular biology 27 (20), 7188-7197, 2007 | 363 | 2007 |
| Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis A Singh, C Happel, SK Manna, G Acquaah-Mensah, J Carrerero, S Kumar, ... The Journal of clinical investigation 123 (7), 2921-2934, 2013 | 336 | 2013 |
| Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide S Shin, J Wakabayashi, MS Yates, N Wakabayashi, PM Dolan, S Aja, ... European journal of pharmacology 620 (1-3), 138-144, 2009 | 302 | 2009 |
| Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein AT Dinkova-Kostova, WD Holtzclaw, N Wakabayashi Biochemistry 44 (18), 6889-6899, 2005 | 261 | 2005 |
