Dagmar Ehrnhoefer
Dagmar Ehrnhoefer
Principal Research Scientist, AbbVie GmbH Co KG, Germany
Verified email at abbvie.com
TitleCited byYear
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
DE Ehrnhoefer, J Bieschke, A Boeddrich, M Herbst, L Masino, R Lurz, ...
Nature structural & molecular biology 15 (6), 558, 2008
10092008
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
J Bieschke, J Russ, RP Friedrich, DE Ehrnhoefer, H Wobst, ...
Proceedings of the National Academy of Sciences 107 (17), 7710-7715, 2010
6482010
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
S Okamoto, MA Pouladi, M Talantova, D Yao, P Xia, DE Ehrnhoefer, ...
Nature medicine 15 (12), 1407, 2009
3622009
Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ...
Human molecular genetics 15 (18), 2743-2751, 2006
3322006
Autophagy in Huntington disease and huntingtin in autophagy
DDO Martin, S Ladha, DE Ehrnhoefer, MR Hayden
Trends in neurosciences 38 (1), 26-35, 2015
1632015
Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease
DE Ehrnhoefer, L Sutton, MR Hayden
The Neuroscientist 17 (5), 475-492, 2011
1242011
Caspase-6 and neurodegeneration
RK Graham, DE Ehrnhoefer, MR Hayden
Trends in neurosciences 34 (12), 646-656, 2011
912011
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ...
Human molecular genetics 19 (8), 1528-1538, 2010
882010
Mouse models of Huntington disease: variations on a theme
DE Ehrnhoefer, SL Butland, MA Pouladi, MR Hayden
Disease models & mechanisms 2 (3-4), 123-129, 2009
762009
Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development
DE Ehrnhoefer, BKY Wong, MR Hayden
Nature reviews Drug discovery 10 (11), 853, 2011
652011
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
B Rotblat, AL Southwell, DE Ehrnhoefer, NH Skotte, M Metzler, ...
Proceedings of the National Academy of Sciences 111 (8), 3032-3037, 2014
542014
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
V Uribe, BKY Wong, RK Graham, CL Cusack, NH Skotte, MA Pouladi, ...
Human molecular genetics 21 (9), 1954-1967, 2012
522012
NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
MA Pouladi, E Brillaud, Y Xie, P Conforti, RK Graham, DE Ehrnhoefer, ...
Neurobiology of disease 48 (3), 282-289, 2012
362012
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits
I Aharony, DE Ehrnhoefer, A Shruster, X Qiu, S Franciosi, MR Hayden, ...
Human molecular genetics 24 (9), 2604-2614, 2015
352015
Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice
BKY Wong, DE Ehrnhoefer, RK Graham, DDO Martin, S Ladha, V Uribe, ...
Neurobiology of disease 76, 24-36, 2015
342015
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin
DE Ehrnhoefer, NH Skotte, S Ladha, YTN Nguyen, X Qiu, Y Deng, ...
Human molecular genetics 23 (3), 717-729, 2013
332013
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6
BJ Van Raam, DE Ehrnhoefer, MR Hayden, GS Salvesen
Cell death and differentiation 20 (1), 86, 2013
282013
A quantitative method for the specific assessment of caspase-6 activity in cell culture
DE Ehrnhoefer, NH Skotte, J Savill, YTN Nguyen, S Ladha, LP Cao, ...
PLoS One 6 (11), e27680, 2011
202011
Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease
JB Carroll, AL Southwell, RK Graham, JP Lerch, DE Ehrnhoefer, LP Cao, ...
Molecular neurodegeneration 6 (1), 59, 2011
192011
Palmitoylation of caspase-6 by HIP14 regulates its activation
NH Skotte, SS Sanders, RR Singaraja, DE Ehrnhoefer, K Vaid, X Qiu, ...
Cell death and differentiation 24 (3), 433, 2017
162017
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