Jian Zhang
Jian Zhang
Shanghai Jiaotong University School of Medicine
Verified email at - Homepage
Cited by
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Predicting protein–protein interactions based only on sequences information
J Shen, J Zhang, X Luo, W Zhu, K Yu, K Chen, Y Li, H Jiang
Proceedings of the National Academy of Sciences 104 (11), 4337-4341, 2007
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
S Shangary, D Qin, D McEachern, M Liu, RS Miller, S Qiu, ...
Proceedings of the National Academy of Sciences 105 (10), 3933-3938, 2008
Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation
D Zhang, Y Wang, Z Shi, J Liu, P Sun, X Hou, J Zhang, S Zhao, BP Zhou, ...
Cell reports 10 (8), 1335-1348, 2015
Ras conformational ensembles, allostery, and signaling
S Lu, H Jang, S Muratcioglu, A Gursoy, O Keskin, R Nussinov, J Zhang
Chemical reviews 116 (11), 6607-6665, 2016
Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells
X Qiu, X Zhu, L Zhang, Y Mao, J Zhang, P Hao, G Li, P Lv, Z Li, X Sun, ...
Cancer research 63 (19), 6488-6495, 2003
Structural basis for activity regulation of MLL family methyltransferases
Y Li, J Han, Y Zhang, F Cao, Z Liu, S Li, J Wu, C Hu, Y Wang, J Shuai, ...
Nature 530 (7591), 447-452, 2016
Identification of a cellularly active SIRT6 allosteric activator
Z Huang, J Zhao, W Deng, Y Chen, J Shang, K Song, L Zhang, C Wang, ...
Nature chemical biology 14 (12), 1118-1126, 2018
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
J Huang, J Yan, J Zhang, S Zhu, Y Wang, T Shi, C Zhu, C Chen, X Liu, ...
Nature communications 3 (1), 911, 2012
The structural basis of oncogenic mutations G12, G13 and Q61 in small GTPase K-Ras4B
S Lu, H Jang, R Nussinov, J Zhang
Scientific reports 6 (1), 21949, 2016
ASD: a comprehensive database of allosteric proteins and modulators
Z Huang, L Zhu, Y Cao, G Wu, X Liu, Y Chen, Q Wang, T Shi, Y Zhao, ...
Nucleic acids research 39 (suppl_1), D663-D669, 2011
Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view
S Lu, H Jang, S Gu, J Zhang, R Nussinov
Chemical Society Reviews 45 (18), 4929-4952, 2016
Allosite: a method for predicting allosteric sites
W Huang, S Lu, Z Huang, X Liu, L Mou, Y Luo, Y Zhao, Y Liu, Z Chen, ...
Bioinformatics 29 (18), 2357-2359, 2013
Crystal structure of HAb18G/CD147 implications for immunoglobulin superfamily homophilic adhesion
XL Yu, T Hu, JM Du, JP Ding, XM Yang, J Zhang, B Yang, X Shen, ...
Journal of Biological Chemistry 283 (26), 18056-18065, 2008
Harnessing allostery: a novel approach to drug discovery
S Lu, S Li, J Zhang
Medicinal research reviews 34 (6), 1242-1285, 2014
Allosteric modulator discovery: from serendipity to structure-based design
S Lu, X He, D Ni, J Zhang
Journal of medicinal chemistry 62 (14), 6405-6421, 2019
Allosteric methods and their applications: Facilitating the discovery of allosteric drugs and the investigation of allosteric mechanisms
S Lu, Q Shen, J Zhang
Accounts of chemical research 52 (2), 492-500, 2019
Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections
Z Qin, J Zhang, B Xu, L Chen, Y Wu, X Yang, X Shen, S Molin, A Danchin, ...
BMC microbiology 6, 1-18, 2006
SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways
H Yuan, Y Han, X Wang, N Li, Q Liu, Y Yin, H Wang, L Pan, L Li, K Song, ...
Cancer Cell 38 (3), 350-365. e7, 2020
ADME evaluation in drug discovery. 9. Prediction of oral bioavailability in humans based on molecular properties and structural fingerprints
S Tian, Y Li, J Wang, J Zhang, T Hou
Molecular pharmaceutics 8 (3), 841-851, 2011
Small molecule allosteric modulators of G-protein-coupled receptors: drug–target interactions
S Lu, J Zhang
Journal of medicinal chemistry 62 (1), 24-45, 2018
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