Kosuke Yusa
Kosuke Yusa
Professor, Kyoto University
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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
H Koike-Yusa, Y Li, EP Tan, MDC Velasco-Herrera, K Yusa
Nature biotechnology 32 (3), 267-273, 2014
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
FM Behan, F Iorio, G Picco, E Gonçalves, CM Beaver, G Migliardi, ...
Nature 568 (7753), 511-516, 2019
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
K Yusa, ST Rashid, H Strick-Marchand, I Varela, PQ Liu, DE Paschon, ...
Nature 478 (7369), 391-394, 2011
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
K Yusa, R Rad, J Takeda, A Bradley
Nature methods 6 (5), 363-369, 2009
A hyperactive piggyBac transposase for mammalian applications
K Yusa, L Zhou, MA Li, A Bradley, NL Craig
Proceedings of the National Academy of Sciences 108 (4), 1531-1536, 2011
A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ...
Cell reports 17 (4), 1193-1205, 2016
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes
P Mali, BK Chou, J Yen, Z Ye, J Zou, S Dowey, RA Brodsky, JE Ohm, ...
Stem cells 28 (4), 713-720, 2010
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
SJ Pettitt, DB Krastev, I Brandsma, A Dréan, F Song, R Aleksandrov, ...
Nature communications 9 (1), 1849, 2018
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice
R Rad, L Rad, W Wang, J Cadinanos, G Vassiliou, S Rice, LS Campos, ...
Science 330 (6007), 1104-1107, 2010
A genetic progression model of BrafV600E-induced intestinal tumorigenesis reveals targets for therapeutic intervention
R Rad, J Cadiñanos, L Rad, I Varela, A Strong, L Kriegl, ...
Cancer cell 24 (1), 15-29, 2013
Mobilization of giant piggyBac transposons in the mouse genome
MA Li, DJ Turner, Z Ning, K Yusa, Q Liang, S Eckert, L Rad, TW Fitzgerald, ...
Nucleic acids research 39 (22), e148-e148, 2011
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice
K Horie, K Yusa, K Yae, J Odajima, SEJ Fischer, VW Keng, T Hayakawa, ...
Molecular and cellular biology, 2003
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets
JM Dempster, C Pacini, S Pantel, FM Behan, T Green, J Krill-Burger, ...
Nature communications 10 (1), 5817, 2019
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
G Balmus, D Pilger, J Coates, M Demir, M Sczaniecka-Clift, AC Barros, ...
Nature communications 10 (1), 87, 2019
Genome-wide CRISPR screens in T helper cells reveal pervasive crosstalk between activation and differentiation
J Henriksson, X Chen, T Gomes, U Ullah, KB Meyer, R Miragaia, G Duddy, ...
Cell 176 (4), 882-896. e18, 2019
Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system
VW Keng, K Yae, T Hayakawa, S Mizuno, Y Uno, K Yusa, C Kokubu, ...
Nature methods 2 (10), 763-769, 2005
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response
S Nagarajan, SV Rao, J Sutton, D Cheeseman, S Dunn, EK Papachristou, ...
Nature genetics 52 (2), 187-197, 2020
Hyperactive piggyBac Gene Transfer in Human Cells and In Vivo
JE Doherty, LE Huye, K Yusa, L Zhou, NL Craig, MH Wilson
Human gene therapy 23 (3), 311-320, 2012
The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation
A Nijnik, S Clare, C Hale, C Raisen, RE McIntyre, K Yusa, AR Everitt, ...
Blood, The Journal of the American Society of Hematology 119 (6), 1370-1379, 2012
Enhancement of Sleeping Beauty Transposition by CpG Methylation: Possible Role of Heterochromatin Formation
K Yusa, J Takeda, K Horie
Molecular and Cellular Biology 24 (9), 4004-4018, 2004
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