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Controlling timing and location in vaccines DJ Irvine, A Aung, M Silva Advanced Drug Delivery Reviews 158, 91-115, 2020 | 194 | 2020 |
Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo Y Kato, RK Abbott, BL Freeman, S Haupt, B Groschel, M Silva, S Menis, ... Immunity 53 (3), 548-563. e8, 2020 | 182 | 2020 |
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques A Escolano, HB Gristick, ME Abernathy, J Merkenschlager, R Gautam, ... Nature 570 (7762), 468-473, 2019 | 153 | 2019 |
Germinal center hypoxia potentiates immunoglobulin class switch recombination RK Abbott, M Thayer, J Labuda, M Silva, P Philbrook, DW Cain, H Kojima, ... The Journal of Immunology 197 (10), 4014-4020, 2016 | 118 | 2016 |
Long-primed germinal centres with enduring affinity maturation and clonal migration JH Lee, HJ Sutton, CA Cottrell, I Phung, G Ozorowski, LM Sewall, ... Nature 609 (7929), 998-1004, 2022 | 117 | 2022 |
Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells S Sethumadhavan, M Silva, P Philbrook, T Nguyen, SM Hatfield, A Ohta, ... PloS one 12 (11), e0187314, 2017 | 114 | 2017 |
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity M Silva, Y Kato, MB Melo, I Phung, BL Freeman, Z Li, K Roh, ... Science immunology 6 (66), eabf1152, 2021 | 89 | 2021 |
Enhancing humoral responses against HIV envelope trimers via nanoparticle delivery with stabilized synthetic liposomes T Tokatlian, DW Kulp, AA Mutafyan, CA Jones, S Menis, E Georgeson, ... Scientific Reports 8 (1), 16527, 2018 | 83 | 2018 |
Immunogenicity of RNA replicons encoding HIV Env immunogens designed for self-assembly into nanoparticles M Melo, E Porter, Y Zhang, M Silva, N Li, B Dobosh, A Liguori, P Skog, ... Molecular Therapy 27 (12), 2080-2090, 2019 | 79 | 2019 |
Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice NC Dalvie, SA Rodriguez-Aponte, BL Hartwell, LH Tostanoski, ... Proceedings of the National Academy of Sciences 118 (38), e2106845118, 2021 | 78 | 2021 |
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity BL Hartwell, MB Melo, P Xiao, AA Lemnios, N Li, JYH Chang, J Yu, ... Science translational medicine 14 (654), eabn1413, 2022 | 56 | 2022 |
Low protease activity in B cell follicles promotes retention of intact antigens after immunization A Aung, A Cui, L Maiorino, AP Amini, JR Gregory, M Bukenya, Y Zhang, ... Science 379 (6630), eabn8934, 2023 | 48 | 2023 |
Can feeding the broiler breeder improve chick quality and offspring performance? A Chang, J Halley, M Silva Animal production science 56 (8), 1254-1262, 2016 | 48 | 2016 |
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization HL Turner, R Andrabi, CA Cottrell, ST Richey, G Song, S Callaghan, ... Science Advances 7 (31), eabh2791, 2021 | 43 | 2021 |
Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env A Escolano, HB Gristick, R Gautam, AT DeLaitsch, ME Abernathy, Z Yang, ... Science translational medicine 13 (621), eabk1533, 2021 | 33 | 2021 |
The GS protein-coupled A2a adenosine receptor controls T cell help in the germinal center RK Abbott, M Silva, J Labuda, M Thayer, DW Cain, P Philbrook, ... Journal of Biological Chemistry 292 (4), 1211-1217, 2017 | 28 | 2017 |
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques W He, M Yuan, S Callaghan, R Musharrafieh, G Song, M Silva, N Beutler, ... Science translational medicine 14 (657), eabl9605, 2022 | 27 | 2022 |
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2 KA Rodrigues, SA Rodriguez-Aponte, NC Dalvie, JH Lee, W Abraham, ... Science advances 7 (50), eabj6538, 2021 | 26 | 2021 |
Targeted elimination of immunodominant B cells drives the germinal center reaction toward subdominant epitopes M Silva, TH Nguyen, P Philbrook, M Chu, O Sears, S Hatfield, RK Abbott, ... Cell reports 21 (13), 3672-3680, 2017 | 26 | 2017 |