| Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes MF McDermott, I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, ... Cell 97 (1), 133-144, 1999 | 1623 | 1999 |
| Cytokine signaling in 2002: new surprises in the Jak/Stat pathway JJ O'Shea, M Gadina, RD Schreiber Cell 109 (2), S121-S131, 2002 | 1477 | 2002 |
| The JAK-STAT pathway: impact on human disease and therapeutic intervention JJ O'Shea, DM Schwartz, AV Villarino, M Gadina, IB McInnes, A Laurence Annual review of medicine 66, 311-328, 2015 | 1407 | 2015 |
| Activated STING in a vascular and pulmonary syndrome Y Liu, AA Jesus, B Marrero, D Yang, SE Ramsey, ... New England Journal of Medicine 371 (6), 507-518, 2014 | 1214 | 2014 |
| JAK inhibition as a therapeutic strategy for immune and inflammatory diseases DM Schwartz, Y Kanno, A Villarino, M Ward, M Gadina, JJ O'Shea Nature reviews Drug discovery 16 (12), 843-862, 2017 | 1170 | 2017 |
| T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells AA Lighvani, DM Frucht, D Jankovic, H Yamane, J Aliberti, BD Hissong, ... Proceedings of the National Academy of Sciences 98 (26), 15137-15142, 2001 | 1092 | 2001 |
| An autoinflammatory disease with deficiency of the interleukin-1–receptor antagonist I Aksentijevich, SL Masters, PJ Ferguson, P Dancey, J Frenkel, ... New England Journal of Medicine 360 (23), 2426-2437, 2009 | 1036 | 2009 |
| JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects S Banerjee, A Biehl, M Gadina, S Hasni, DM Schwartz Drugs 77, 521-546, 2017 | 948 | 2017 |
| Early-onset stroke and vasculopathy associated with mutations in ADA2 Q Zhou, D Yang, AK Ombrello, AV Zavialov, C Toro, AV Zavialov, ... New England Journal of Medicine 370 (10), 911-920, 2014 | 788 | 2014 |
| Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease EF Remmers, F Cosan, Y Kirino, MJ Ombrello, N Abaci, C Satorius, JM Le, ... Nature genetics 42 (8), 698-702, 2010 | 758 | 2010 |
| Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550) K Ghoreschi, MI Jesson, X Li, JL Lee, S Ghosh, JW Alsup, JD Warner, ... The Journal of Immunology 186 (7), 4234-4243, 2011 | 694 | 2011 |
| Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease DB Beck, MA Ferrada, KA Sikora, AK Ombrello, JC Collins, W Pei, ... New England Journal of Medicine 383 (27), 2628-2638, 2020 | 679 | 2020 |
| Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases DM Schwartz, M Bonelli, M Gadina, JJ O'shea Nature Reviews Rheumatology 12 (1), 25-36, 2016 | 643 | 2016 |
| Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection KB Nguyen, WT Watford, R Salomon, SR Hofmann, GC Pien, A Morinobu, ... Science 297 (5589), 2063-2066, 2002 | 634 | 2002 |
| Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights D Agnello, CSR Lankford, J Bream, A Morinobu, M Gadina, JJ O'Shea, ... Journal of clinical immunology 23, 147-161, 2003 | 603 | 2003 |
| Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation V Parravicini, M Gadina, M Kovarova, S Odom, C Gonzalez-Espinosa, ... Nature immunology 3 (8), 741-748, 2002 | 554 | 2002 |
| Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ... Nature genetics 48 (1), 67-73, 2016 | 547 | 2016 |
| JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies GAM Sanchez, A Reinhardt, S Ramsey, H Wittkowski, PJ Hashkes, ... The Journal of clinical investigation 128 (7), 3041-3052, 2018 | 449 | 2018 |
| Type 2 immunity in the skin and lungs CA Akdis, PD Arkwright, MC Brüggen, W Busse, M Gadina, ... Allergy 75 (7), 1582-1605, 2020 | 373 | 2020 |
| Super-enhancers delineate disease-associated regulatory nodes in T cells G Vahedi, Y Kanno, Y Furumoto, K Jiang, SCJ Parker, MR Erdos, ... Nature 520 (7548), 558-562, 2015 | 371 | 2015 |
John J. OSheaNational Institutes of HealthVerified email at mail.nih.gov
