|Cytokine signaling in 2002: new surprises in the Jak/Stat pathway|
JJ O'Shea, M Gadina, RD Schreiber
Cell 109 (2), S121-S131, 2002
|Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes|
MF McDermott, I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, ...
Cell 97 (1), 133-144, 1999
|T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells|
AA Lighvani, DM Frucht, D Jankovic, H Yamane, J Aliberti, BD Hissong, ...
Proceedings of the National Academy of Sciences 98 (26), 15137-15142, 2001
|An autoinflammatory disease with deficiency of the interleukin-1–receptor antagonist|
I Aksentijevich, SL Masters, PJ Ferguson, P Dancey, J Frenkel, ...
New England Journal of Medicine 360 (23), 2426-2437, 2009
|Activated STING in a vascular and pulmonary syndrome|
Y Liu, AA Jesus, B Marrero, D Yang, SE Ramsey, ...
New England Journal of Medicine 371 (6), 507-518, 2014
|Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease|
EF Remmers, F Cosan, Y Kirino, MJ Ombrello, N Abaci, C Satorius, JM Le, ...
Nature genetics 42 (8), 698-702, 2010
|Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights|
D Agnello, CSR Lankford, J Bream, A Morinobu, M Gadina, JJ O'Shea, ...
Journal of clinical immunology 23 (3), 147-161, 2003
|Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection|
KB Nguyen, WT Watford, R Salomon, SR Hofmann, GC Pien, A Morinobu, ...
Science 297 (5589), 2063-2066, 2002
|The JAK-STAT pathway: impact on human disease and therapeutic intervention|
JJ O'Shea, DM Schwartz, AV Villarino, M Gadina, IB McInnes, A Laurence
Annual review of medicine 66, 311-328, 2015
|Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation|
V Parravicini, M Gadina, M Kovarova, S Odom, C Gonzalez-Espinosa, ...
Nature immunology 3 (8), 741-748, 2002
|Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)|
K Ghoreschi, MI Jesson, X Li, JL Lee, S Ghosh, JW Alsup, JD Warner, ...
The Journal of Immunology 186 (7), 4234-4243, 2011
|Early-onset stroke and vasculopathy associated with mutations in ADA2|
Q Zhou, D Yang, AK Ombrello, AV Zavialov, C Toro, AV Zavialov, ...
New England Journal of Medicine 370 (10), 911-920, 2014
|Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes|
D Franchimont, J Galon, M Gadina, R Visconti, YJ Zhou, M Aringer, ...
The Journal of Immunology 164 (4), 1768-1774, 2000
|Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease|
Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ...
Nature genetics 48 (1), 67, 2016
|Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases|
DM Schwartz, M Bonelli, M Gadina, JJ O'shea
Nature Reviews Rheumatology 12 (1), 25, 2016
|Signaling by type I and II cytokine receptors: ten years after|
M Gadina, D Hilton, JA Johnston, A Morinobu, A Lighvani, YJ Zhou, ...
Current opinion in immunology 13 (3), 363-373, 2001
|Super-enhancers delineate disease-associated regulatory nodes in T cells|
G Vahedi, Y Kanno, Y Furumoto, K Jiang, SCJ Parker, MR Erdos, ...
Nature 520 (7548), 558-562, 2015
|Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses|
T Fukao, DM Frucht, G Yap, M Gadina, JJ O’Shea, S Koyasu
The Journal of Immunology 166 (7), 4446-4455, 2001
|JAK inhibition as a therapeutic strategy for immune and inflammatory diseases|
DM Schwartz, Y Kanno, A Villarino, M Ward, M Gadina, JJ O'Shea
Nature reviews Drug discovery 16 (12), 843-862, 2017
|IL-12 receptor β2 (IL-12Rβ2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites|
C Wu, X Wang, M Gadina, JJ O’Shea, DH Presky, J Magram
The Journal of Immunology 165 (11), 6221-6228, 2000