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Ed Griffen
Ed Griffen
MedChemica Ltd
Verified email at medchemica.com
Title
Cited by
Cited by
Year
Matched molecular pairs as a medicinal chemistry tool: miniperspective
E Griffen, AG Leach, GR Robb, DJ Warner
Journal of medicinal chemistry 54 (22), 7739-7750, 2011
2812011
Fragment screening: an introduction
AR Leach, MM Hann, JN Burrows, EJ Griffen
Molecular BioSystems 2 (9), 429-446, 2006
2132006
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ...
Cell Stem Cell 29 (2), 217-231. e8, 2022
1652022
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes
JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ...
Current Topics in Medicinal Chemistry 7 (16), 1600-1629, 2007
1482007
Matched molecular pair analysis in drug discovery
AG Dossetter, EJ Griffen, AG Leach
Drug Discovery Today 18 (15-16), 724-731, 2013
1432013
WizePairZ: a novel algorithm to identify, encode, and exploit matched molecular pairs with unspecified cores in medicinal chemistry
DJ Warner, EJ Griffen, SA St-Gallay
Journal of chemical information and modeling 50 (8), 1350-1357, 2010
802010
Learning medicinal chemistry absorption, distribution, metabolism, excretion, and toxicity (ADMET) rules from cross-company matched molecular pairs analysis (MMPA) miniperspective
C Kramer, A Ting, H Zheng, J Hert, T Schindler, M Stahl, G Robb, ...
Journal of medicinal chemistry 61 (8), 3277-3292, 2017
762017
Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and artificial intelligence?
EJ Griffen, AG Dossetter, AG Leach, S Montague
Drug discovery today 23 (7), 1373-1384, 2018
582018
Benzenoid ring functionalization of indoles and tryptophols via combined directed ortho metalation-cross coupling methodology
EJ Griffen, DG Roe, V Snieckus
The journal of organic chemistry 60 (6), 1484-1485, 1995
561995
COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine …
H Achdout, A Aimon, E Bar-David, GM Morris
BioRxiv, 2020
532020
An orally bioavailable, indole-3-glyoxylamide based series of tubulin polymerization inhibitors showing tumor growth inhibition in a mouse xenograft model of head and neck cancer
HE Colley, M Muthana, SJ Danson, LV Jackson, ML Brett, J Harrison, ...
Journal of medicinal chemistry 58 (23), 9309-9333, 2015
522015
A white-knuckle ride of open COVID drug discovery
F von Delft, M Calmiano, J Chodera, E Griffen, A Lee, N London, ...
Nature 594 (7863), 330-332, 2021
352021
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors
COVID Moonshot Consortium, H Achdout, A Aimon, DS Alonzi, R Arbon, ...
BioRxiv, 2020.10. 29.339317, 2020
352020
Chemists: AI is here; unite to get the benefits
EJ Griffen, AG Dossetter, AG Leach
Journal of Medicinal Chemistry 63 (16), 8695-8704, 2020
342020
2-benzimidazolyl-6-morpholino-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
S Butterworth, EJ Griffen, M Pass
US Patent App. 12/441,299, 2009
342009
DNA-dependent protein kinase (DNA-PK) inhibitors: structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain
KM Clapham, J Bardos, MRV Finlay, BT Golding, EJ Griffen, RJ Griffin, ...
Bioorganic & medicinal chemistry letters 21 (3), 966-970, 2011
292011
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, ...
Science 382 (6671), eabo7201, 2023
212023
Turbocharging matched molecular pair analysis: optimizing the identification and analysis of Pairs
I Lukac, J Zarnecka, EJ Griffen, AG Dossetter, SA St-Gallay, SJ Enoch, ...
Journal of Chemical Information and Modeling 57 (10), 2424-2436, 2017
182017
5-heteroaryl thiazoles and their use as PI3K inhibitors
M Bengtsson, J Larsson, G Nikitidis, P Storm, JP Bailey, EJ Griffen, ...
US Patent 7,868,188, 2011
172011
5-heteroaryl thiazoles and their use as PI3K inhibitors
M Bengtsson, J Larsson, G Nikitidis, P Storm, JP Bailey, EJ Griffen, ...
US Patent 7,868,188, 2011
172011
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