| A PDZ-interacting domain in CFTR is an apical membrane polarization signal BD Moyer, J Denton, KH Karlson, D Reynolds, S Wang, JE Mickle, ... The Journal of clinical investigation 104 (10), 1353-1361, 1999 | 357 | 1999 |
| The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membrane BD Moyer, M Duhaime, C Shaw, J Denton, D Reynolds, KH Karlson, ... Journal of Biological Chemistry 275 (35), 27069-27074, 2000 | 206 | 2000 |
| G-protein-independent coupling of MC4R to Kir7. 1 in hypothalamic neurons M Ghamari-Langroudi, GJ Digby, JA Sebag, GL Millhauser, R Palomino, ... Nature 520 (7545), 94-98, 2015 | 197 | 2015 |
| ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice K Kaufmann, I Romaine, E Days, C Pascual, A Malik, L Yang, B Zou, Y Du, ... ACS chemical neuroscience 4 (9), 1278-1286, 2013 | 158 | 2013 |
| High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7. 1 LM Lewis, G Bhave, BA Chauder, S Banerjee, KA Lornsen, R Redha, ... Molecular pharmacology 76 (5), 1094-1103, 2009 | 135 | 2009 |
| Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume K Strange, J Denton, K Nehrke Physiology 21 (1), 61-68, 2006 | 123 | 2006 |
| Development of a selective small-molecule inhibitor of Kir1. 1, the renal outer medullary potassium channel G Bhave, BA Chauder, W Liu, ES Dawson, R Kadakia, TT Nguyen, ... Molecular pharmacology 79 (1), 42-50, 2011 | 122 | 2011 |
| A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel K Strange, T Yamada, JS Denton Journal of General Physiology 151 (2), 100-117, 2019 | 91 | 2019 |
| Intracellular H+ regulates the α-subunit of ENaC, the epithelial Na+ channel ML Chalfant, JS Denton, BK Berdiev, II Ismailov, DJ Benos, BA Stanton American Journal of Physiology-Cell Physiology 276 (2), C477-C486, 1999 | 86 | 1999 |
| Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities G Bhave, D Lonergan, BA Chauder, JS Denton Future medicinal chemistry 2 (5), 757-774, 2010 | 83 | 2010 |
| The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy C McCloskey, C Rada, E Bailey, S McCavera, HA van den Berg, J Atia, ... EMBO molecular medicine 6 (9), 1161-1174, 2014 | 77 | 2014 |
| Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels R Raphemot, MF Rouhier, CR Hopkins, RD Gogliotti, KM Lovell, RM Hine, ... PloS one 8 (5), e64905, 2013 | 77 | 2013 |
| An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria DR Swale, DW Engers, SR Bollinger, A Gross, EA Inocente, E Days, ... Scientific reports 6 (1), 36954, 2016 | 73 | 2016 |
| GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle–dependent ClC anion channel J Denton, K Nehrke, X Yin, R Morrison, K Strange The Journal of general physiology 125 (2), 113-125, 2005 | 70 | 2005 |
| Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program K Nehrke, J Denton, W Mowrey American Journal of Physiology-Cell Physiology 294 (1), C333-C344, 2008 | 65 | 2008 |
| The Kir channel immunoglobulin domain is essential for Kir1. 1 (ROMK) thermodynamic stability, trafficking and gating K Fallen, S Banerjee, J Sheehan, D Addison, LM Lewis, J Meiler, ... Channels 3 (1), 57-68, 2009 | 62 | 2009 |
| The NH2 terminus of the epithelial sodium channel contains an endocytic motif ML Chalfant, JS Denton, AL Langloh, KH Karlson, J Loffing, DJ Benos, ... Journal of Biological Chemistry 274 (46), 32889-32896, 1999 | 59 | 1999 |
| Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels R Raphemot, MF Rouhier, DR Swale, E Days, CD Weaver, KM Lovell, ... PloS one 9 (11), e110772, 2014 | 53 | 2014 |
| Discovery, characterization, and structure–activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2. 3, Kir3. x, and Kir7. 1 R Raphemot, DF Lonergan, TT Nguyen, T Utley, LM Lewis, R Kadakia, ... Frontiers in pharmacology 2, 75, 2011 | 53 | 2011 |
| Cell cycle– and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7α/β phosphatases E Rutledge, J Denton, K Strange The Journal of cell biology 158 (3), 435-444, 2002 | 52 | 2002 |
