| TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain EM Frickel, R Riek, I Jelesarov, A Helenius, K Wüthrich, L Ellgaard Proceedings of the National Academy of Sciences 99 (4), 1954-1959, 2002 | 336 | 2002 |
| CD8α+ dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites M Mashayekhi, MM Sandau, IR Dunay, EM Frickel, A Khan, ... Immunity 35 (2), 249-259, 2011 | 311 | 2011 |
| ERp57 is a multifunctional thiol-disulfide oxidoreductase EM Frickel, P Frei, M Bouvier, WF Stafford, A Helenius, R Glockshuber, ... Journal of Biological Chemistry 279 (18), 18277-18287, 2004 | 212 | 2004 |
| Calnexin, calreticulin, and ERp57 L Ellgaard, EM Frickel Cell biochemistry and biophysics 39 (3), 223-247, 2003 | 202 | 2003 |
| IRG and GBP host resistance factors target aberrant,“non-self” vacuoles characterized by the missing of “self” IRGM proteins AK Haldar, HA Saka, AS Piro, JD Dunn, SC Henry, GA Taylor, EM Frickel, ... PLoS Pathog 9 (6), e1003414, 2013 | 124 | 2013 |
| Parasite Stage-Specific Recognition of Endogenous Toxoplasma gondii-Derived CD8+ T Cell Epitopes EM Frickel, N Sahoo, J Hopp, MJ Gubbels, MPJ Craver, LJ Knoll, ... The Journal of infectious diseases 198 (11), 1625-1633, 2008 | 112 | 2008 |
| Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it SV Winter, W Niedelman, KD Jensen, EE Rosowski, L Julien, E Spooner, ... PloS one 6 (9), e24434, 2011 | 107 | 2011 |
| Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins AK Haldar, C Foltz, R Finethy, AS Piro, EM Feeley, DM Pilla-Moffett, ... Proceedings of the National Academy of Sciences 112 (41), E5628-E5637, 2015 | 100 | 2015 |
| Differential regulation of effector-and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells DC Wilson, GM Grotenbreg, K Liu, Y Zhao, EM Frickel, MJ Gubbels, ... PLoS Pathog 6 (3), e1000815, 2010 | 99 | 2010 |
| Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation MS Kulp, EM Frickel, L Ellgaard, JS Weissman Journal of Biological Chemistry 281 (2), 876-884, 2006 | 84 | 2006 |
| Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution EM Frickel, V Quesada, L Muething, MJ Gubbels, E Spooner, H Ploegh, ... Cellular microbiology 9 (6), 1601-1610, 2007 | 72 | 2007 |
| Yeast glyoxalase I is a monomeric enzyme with two active sites EM Frickel, P Jemth, M Widersten, B Mannervik Journal of Biological Chemistry 276 (3), 1845-1849, 2001 | 64 | 2001 |
| The toxoplasma parasitophorous vacuole: an evolving host–parasite frontier B Clough, EM Frickel Trends in parasitology 33 (6), 473-488, 2017 | 61 | 2017 |
| Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT O Kirak, EM Frickel, GM Grotenbreg, H Suh, R Jaenisch, HL Ploegh Science 328 (5975), 243-248, 2010 | 61 | 2010 |
| Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication W Niedelman, JK Sprokholt, B Clough, EM Frickel, JPJ Saeij Infection and immunity 81 (12), 4341-4349, 2013 | 52 | 2013 |
| Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii AC Johnston, A Piro, B Clough, M Siew, S Virreira Winter, J Coers, ... Cellular microbiology 18 (8), 1056-1064, 2016 | 47 | 2016 |
| Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination KDC Jensen, A Camejo, MB Melo, C Cordeiro, L Julien, GM Grotenbreg, ... MBio 6 (2), 2015 | 47 | 2015 |
| Human GBP 1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis D Fisch, H Bando, B Clough, V Hornung, M Yamamoto, AR Shenoy, ... The EMBO journal 38 (13), e100926, 2019 | 43 | 2019 |
| K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells B Clough, JD Wright, PM Pereira, EM Hirst, AC Johnston, R Henriques, ... PLoS pathogens 12 (11), e1006027, 2016 | 43 | 2016 |
| Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility AS Piro, D Hernandez, S Luoma, EM Feeley, R Finethy, A Yirga, ... MBio 8 (6), 2017 | 40 | 2017 |
Hidde PloeghSenior Investigator, Program in Cellular and Molecular Medicine, Boston Children's HospitalVerified email at childrens.harvard.edu
