Peter James O'Brien
Peter James O'Brien
Lecturer, School of Veterinary Medicine, UCD
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Cited by
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Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia
J Fujii, K Otsu, F Zorzato, S de Leon, VJ Khanna, JE Weiler, PJ O'Brien, ...
Science 253 (5018), 448-451, 1991
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
PJ O’Brien, W Irwin, D Diaz, E Howard-Cofield, CM Krejsa, MR Slaughter, ...
Archives of Toxicology 80 (9), 580-604, 2006
Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals
PJ O'Brien, DEC Smith, TJ Knechtel, MA Marchak, I Pruimboom-Brees, ...
Laboratory Animals 40 (2), 153-171, 2006
Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity
PJ O’Brien
Toxicology 245 (3), 206-218, 2008
Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential
JJ Xu, D Diaz, PJ O’Brien
Chemico-Biological Interactions 150 (1), 115-128, 2004
Thyroidal trophic influence on skeletal muscle myosin
D Ianuzzo, P Patel, V Chen, P O'Brien, C Williams
Nature 270 (5632), 74-76, 1977
Differential reactivity of cardiac and skeletal muscle from various species in a cardiac troponin I immunoassay
PJ O’Brien, Y Landt, JH Ladenson
Clinical Chemistry 43 (12), 2333-2338, 1997
Cardiac troponin T is a sensitive, specific biomarker of cardiac injury in laboratory animals
PJ O'Brien, GW Dameron, ML Beck, YJ Kang, BK Erickson, THI Di Battista, ...
Comparative Medicine 47 (5), 486-495, 1997
Advantages of glutamate dehydrogenase as a plasma biomarker of acute hepatic injury in rats
PJ O'Brien, MR Slaughter, R McKinnon, K Kramer
Laboratory Animals 36 (3), 313-321, 2002
Cellular adaptations of the ventilatory muscles to a chronic increased respiratory load
TG Keens, V Chen, P Patel, P O'Brien, H Levison, CD Ianuzzo
Journal of Applied Physiology 44 (6), 905-908, 1978
Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies
PJ O'Brien, CD Ianuzzo, GW Moe, TP Stopps, PW Armstrong
Canadian Journal of Physiology and Pharmacology 68 (1), 34-39, 1990
Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system
PJ O'Brien, MR Slaughter, A Swain, JM Birmingham, RW Greenhill, ...
Human & Experimental Toxicology 19 (5), 277-283, 2000
Compensatory downregulation of myocardial Ca channel in sarcoplasmic reticulum from dogs with heart failure
CR Cory, LJ McCutcheon, AW Pang, JD Geiger, O'Brien PJ
Am J Physiol - Heart Circulatory Physiol 264 (3), H926-H937, 1993
Use of a DNA-based test for the mutation associated with porcine stress syndrome (malignant hyperthermia) in 10,000 breeding swine.
PJ O'Brien, H Shen, CR Cory, X Zhang
Journal of the American Veterinary Medical Association 203 (6), 842-851, 1993
High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles
Anguissola S, Garry D, Salvati A, O'Brien PJ, Dawson KA
PLOS One 9 ((9)), 1-16, 2014
Veterinary and toxicological applications for the detection of cardiac injury using cardiac troponin
M Serra, S Papakonstantinou, M Adamcova, PJ O’Brien
The Veterinary Journal 185 (1), 50-57, 2010
High-content analysis in toxicology: screening substances for human toxicity potential, elucidating subcellular mechanisms, and in vivo use as translational safety biomarkers
O'Brien PJ
Basic & Clinical Pharmacology & Toxicology 115 (1), 4-17, 2014
Fully-automated spectrophotometric method for measurement of antioxidant activity of catalase
MR Slaughter, PJ O’Brien
Clinical Biochemistry 33 (7), 525-534, 2000
In vitro cytotoxicity assessment
P O Brien, J Haskins
Methods in Molecular Biology 356, 415-425, 2006
Rapid, simple and sensitive microassay for skeletal and cardiac muscle myoglobin and hemoglobin: use in various animals indicates functional role of myohemoproteins
PJ O'Brien, H Shen, LJ McCutcheon, M O'Grady, PJ Byrne, HW Ferguson, ...
Molecular and Cellular Biochemistry 112 (1), 45-52, 1992
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