| Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia J Fujii, K Otsu, F Zorzato, S de Leon, VJ Khanna, JE Weiler, PJ O'Brien, ... Science 253 (5018), 448-451, 1991 | 2229 | 1991 |
| High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening PJ O’Brien, W Irwin, D Diaz, E Howard-Cofield, CM Krejsa, MR Slaughter, ... Archives of Toxicology 80 (9), 580-604, 2006 | 699 | 2006 |
| Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals PJ O'Brien, DEC Smith, TJ Knechtel, MA Marchak, I Pruimboom-Brees, ... Laboratory Animals 40 (2), 153-171, 2006 | 373 | 2006 |
| Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity PJ O’Brien Toxicology 245 (3), 206-218, 2008 | 319 | 2008 |
| Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential JJ Xu, D Diaz, PJ O’Brien Chemico-Biological Interactions 150 (1), 115-128, 2004 | 273 | 2004 |
| Thyroidal trophic influence on skeletal muscle myosin D Ianuzzo, P Patel, V Chen, P O'Brien, C Williams Nature 270 (5632), 74-76, 1977 | 243 | 1977 |
| Differential reactivity of cardiac and skeletal muscle from various species in a cardiac troponin I immunoassay PJ O’Brien, Y Landt, JH Ladenson Clinical Chemistry 43 (12), 2333-2338, 1997 | 222 | 1997 |
| Cardiac troponin T is a sensitive, specific biomarker of cardiac injury in laboratory animals PJ O'Brien, GW Dameron, ML Beck, YJ Kang, BK Erickson, THI Di Battista, ... Comparative Medicine 47 (5), 486-495, 1997 | 189 | 1997 |
| Advantages of glutamate dehydrogenase as a plasma biomarker of acute hepatic injury in rats PJ O'Brien, MR Slaughter, R McKinnon, K Kramer Laboratory Animals 36 (3), 313-321, 2002 | 185 | 2002 |
| Cellular adaptations of the ventilatory muscles to a chronic increased respiratory load TG Keens, V Chen, P Patel, P O'Brien, H Levison, CD Ianuzzo Journal of Applied Physiology 44 (6), 905-908, 1978 | 155 | 1978 |
| Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies PJ O'Brien, CD Ianuzzo, GW Moe, TP Stopps, PW Armstrong Canadian Journal of Physiology and Pharmacology 68 (1), 34-39, 1990 | 141 | 1990 |
| High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles Anguissola S, Garry D, Salvati A, O'Brien PJ, Dawson KA PLOS One 9 ((9)), 1-16, 2014 | 129* | 2014 |
| Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system PJ O'Brien, MR Slaughter, A Swain, JM Birmingham, RW Greenhill, ... Human & Experimental Toxicology 19 (5), 277-283, 2000 | 116 | 2000 |
| Veterinary and toxicological applications for the detection of cardiac injury using cardiac troponin M Serra, S Papakonstantinou, M Adamcova, PJ O’Brien The Veterinary Journal 185 (1), 50-57, 2010 | 110 | 2010 |
| Compensatory downregulation of myocardial Ca channel in sarcoplasmic reticulum from dogs with heart failure CR Cory, LJ McCutcheon, AW Pang, JD Geiger, O'Brien PJ Am J Physiol - Heart Circulatory Physiol 264 (3), H926-H937, 1993 | 104 | 1993 |
| Use of a DNA-based test for the mutation associated with porcine stress syndrome (malignant hyperthermia) in 10,000 breeding swine. PJ O'Brien, H Shen, CR Cory, X Zhang Journal of the American Veterinary Medical Association 203 (6), 842-851, 1993 | 100 | 1993 |
| Fully-automated spectrophotometric method for measurement of antioxidant activity of catalase MR Slaughter, PJ O’Brien Clinical Biochemistry 33 (7), 525-534, 2000 | 96 | 2000 |
| High-content analysis in toxicology: screening substances for human toxicity potential, elucidating subcellular mechanisms, and in vivo use as translational safety biomarkers O'Brien PJ Basic & Clinical Pharmacology & Toxicology 115 (1), 4-17, 2014 | 90 | 2014 |
| In vitro cytotoxicity assessment P O Brien, J Haskins Methods in Molecular Biology 356, 415-425, 2006 | 88 | 2006 |
| Rapid, simple and sensitive microassay for skeletal and cardiac muscle myoglobin and hemoglobin: use in various animals indicates functional role of myohemoproteins PJ O'Brien, H Shen, LJ McCutcheon, M O'Grady, PJ Byrne, HW Ferguson, ... Molecular and Cellular Biochemistry 112 (1), 45-52, 1992 | 78 | 1992 |
Francesco ZorzatoUniversity of FerraraVerified email at unife.it
