Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E Moreno, S Jangra, ... Science 371 (6532), 926-931, 2021 | 294 | 2021 |
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial R Nachbagauer, J Feser, A Naficy, DI Bernstein, J Guptill, EB Walter, ... Nature medicine 27 (1), 106-114, 2021 | 242 | 2021 |
Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens RD Antrobus, L Coughlan, TK Berthoud, MD Dicks, AVS Hill, T Lambe, ... Molecular therapy 22 (3), 668-674, 2014 | 232 | 2014 |
A multi-targeting, nucleoside-modified mRNA influenza virus vaccine provides broad protection in mice AW Freyn, JR da Silva, VC Rosado, CM Bliss, M Pine, BL Mui, YK Tam, ... Molecular Therapy 28 (7), 1569-1584, 2020 | 202 | 2020 |
Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection R Rathnasinghe, S Strohmeier, F Amanat, VL Gillespie, F Krammer, ... Emerging microbes & infections 9 (1), 2433-2445, 2020 | 173 | 2020 |
Heterologous two-dose vaccination with simian adenovirus and poxvirus vectors elicits long-lasting cellular immunity to influenza virus A in healthy adults L Coughlan, S Sridhar, R Payne, M Edmans, A Milicic, N Venkatraman, ... EBioMedicine 29, 146-154, 2018 | 146 | 2018 |
Tropism-modification strategies for targeted gene delivery using adenoviral vectors L Coughlan, R Alba, AL Parker, AC Bradshaw, IA McNeish, SA Nicklin, ... Viruses 2 (10), 2290-2355, 2010 | 137 | 2010 |
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome AT Baker, RJ Boyd, D Sarkar, A Teijeira-Crespo, CK Chan, E Bates, ... Science Advances 7 (49), eabl8213, 2021 | 129 | 2021 |
Coadministration of seasonal influenza vaccine and MVA-NP+ M1 simultaneously achieves potent humoral and cell-mediated responses RD Antrobus, TK Berthoud, CE Mullarkey, K Hoschler, L Coughlan, ... Molecular Therapy 22 (1), 233-238, 2014 | 127 | 2014 |
Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines L Coughlan Frontiers in immunology 11, 530926, 2020 | 121 | 2020 |
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors R Alba, AC Bradshaw, L Coughlan, L Denby, RA McDonald, ... Blood, The Journal of the American Society of Hematology 116 (15), 2656-2664, 2010 | 112 | 2010 |
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans HL Dugan, JJ Guthmiller, P Arevalo, M Huang, YQ Chen, KE Neu, ... Science translational medicine 12 (573), eabd3601, 2020 | 93 | 2020 |
Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X AC Bradshaw, AL Parker, MR Duffy, L Coughlan, N van Rooijen, ... PLoS pathogens 6 (10), e1001142, 2010 | 90 | 2010 |
Broadly neutralizing antibodies target a haemagglutinin anchor epitope JJ Guthmiller, J Han, HA Utset, L Li, LYL Lan, C Henry, CT Stamper, ... Nature 602 (7896), 314-320, 2022 | 79 | 2022 |
In vivo retargeting of adenovirus type 5 to αvβ6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery L Coughlan, S Vallath, A Saha, M Flak, IA McNeish, G Vassaux, ... Journal of virology 83 (13), 6416-6428, 2009 | 77 | 2009 |
Overcoming barriers in the path to a universal influenza virus vaccine L Coughlan, P Palese Cell Host & Microbe 24 (1), 18-24, 2018 | 75 | 2018 |
Polyreactive broadly neutralizing B cells are selected to provide defense against pandemic threat influenza viruses JJ Guthmiller, LYL Lan, ML Fernández-Quintero, J Han, HA Utset, DJ Bitar, ... Immunity 53 (6), 1230-1244. e5, 2020 | 69 | 2020 |
A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses W Sun, Y Liu, F Amanat, I González-Domínguez, S McCroskery, ... Nature communications 12 (1), 6197, 2021 | 60 | 2021 |
Ad5: Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery L Coughlan, AC Bradshaw, AL Parker, H Robinson, K White, J Custers, ... Molecular Therapy 20 (12), 2268-2281, 2012 | 58 | 2012 |
Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions AT Baker, A Greenshields-Watson, L Coughlan, JA Davies, ... Nature communications 10 (1), 741, 2019 | 55 | 2019 |