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Lynda Coughlan
Lynda Coughlan
University of Maryland School of Medicine
Verified email at som.umaryland.edu
Title
Cited by
Cited by
Year
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E Moreno, S Jangra, ...
Science 371 (6532), 926-931, 2021
2942021
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial
R Nachbagauer, J Feser, A Naficy, DI Bernstein, J Guptill, EB Walter, ...
Nature medicine 27 (1), 106-114, 2021
2422021
Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens
RD Antrobus, L Coughlan, TK Berthoud, MD Dicks, AVS Hill, T Lambe, ...
Molecular therapy 22 (3), 668-674, 2014
2322014
A multi-targeting, nucleoside-modified mRNA influenza virus vaccine provides broad protection in mice
AW Freyn, JR da Silva, VC Rosado, CM Bliss, M Pine, BL Mui, YK Tam, ...
Molecular Therapy 28 (7), 1569-1584, 2020
2022020
Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection
R Rathnasinghe, S Strohmeier, F Amanat, VL Gillespie, F Krammer, ...
Emerging microbes & infections 9 (1), 2433-2445, 2020
1732020
Heterologous two-dose vaccination with simian adenovirus and poxvirus vectors elicits long-lasting cellular immunity to influenza virus A in healthy adults
L Coughlan, S Sridhar, R Payne, M Edmans, A Milicic, N Venkatraman, ...
EBioMedicine 29, 146-154, 2018
1462018
Tropism-modification strategies for targeted gene delivery using adenoviral vectors
L Coughlan, R Alba, AL Parker, AC Bradshaw, IA McNeish, SA Nicklin, ...
Viruses 2 (10), 2290-2355, 2010
1372010
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
AT Baker, RJ Boyd, D Sarkar, A Teijeira-Crespo, CK Chan, E Bates, ...
Science Advances 7 (49), eabl8213, 2021
1292021
Coadministration of seasonal influenza vaccine and MVA-NP+ M1 simultaneously achieves potent humoral and cell-mediated responses
RD Antrobus, TK Berthoud, CE Mullarkey, K Hoschler, L Coughlan, ...
Molecular Therapy 22 (1), 233-238, 2014
1272014
Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines
L Coughlan
Frontiers in immunology 11, 530926, 2020
1212020
Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors
R Alba, AC Bradshaw, L Coughlan, L Denby, RA McDonald, ...
Blood, The Journal of the American Society of Hematology 116 (15), 2656-2664, 2010
1122010
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
HL Dugan, JJ Guthmiller, P Arevalo, M Huang, YQ Chen, KE Neu, ...
Science translational medicine 12 (573), eabd3601, 2020
932020
Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X
AC Bradshaw, AL Parker, MR Duffy, L Coughlan, N van Rooijen, ...
PLoS pathogens 6 (10), e1001142, 2010
902010
Broadly neutralizing antibodies target a haemagglutinin anchor epitope
JJ Guthmiller, J Han, HA Utset, L Li, LYL Lan, C Henry, CT Stamper, ...
Nature 602 (7896), 314-320, 2022
792022
In vivo retargeting of adenovirus type 5 to αvβ6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery
L Coughlan, S Vallath, A Saha, M Flak, IA McNeish, G Vassaux, ...
Journal of virology 83 (13), 6416-6428, 2009
772009
Overcoming barriers in the path to a universal influenza virus vaccine
L Coughlan, P Palese
Cell Host & Microbe 24 (1), 18-24, 2018
752018
Polyreactive broadly neutralizing B cells are selected to provide defense against pandemic threat influenza viruses
JJ Guthmiller, LYL Lan, ML Fernández-Quintero, J Han, HA Utset, DJ Bitar, ...
Immunity 53 (6), 1230-1244. e5, 2020
692020
A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses
W Sun, Y Liu, F Amanat, I González-Domínguez, S McCroskery, ...
Nature communications 12 (1), 6197, 2021
602021
Ad5: Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery
L Coughlan, AC Bradshaw, AL Parker, H Robinson, K White, J Custers, ...
Molecular Therapy 20 (12), 2268-2281, 2012
582012
Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
AT Baker, A Greenshields-Watson, L Coughlan, JA Davies, ...
Nature communications 10 (1), 741, 2019
552019
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