Efficient sensitivity analysis of large-scale differential-algebraic systems WF Feehery, JE Tolsma, PI Barton Applied Numerical Mathematics 25 (1), 41-54, 1997 | 284 | 1997 |

DAEPACK: An open modeling environment for legacy models J Tolsma, PI Barton Industrial & Engineering Chemistry Research 39 (6), 1826-1839, 2000 | 125 | 2000 |

Optimal design and operation of a natural gas tri-reforming reactor for DME synthesis W Cho, T Song, A Mitsos, JT McKinnon, GH Ko, JE Tolsma, D Denholm, ... Catalysis Today 139 (4), 261-267, 2009 | 103 | 2009 |

On upgrading the numerics in combustion chemistry codes DA Schwer, JE Tolsma, WH Green Jr, PI Barton Combustion and Flame 128 (3), 270-291, 2002 | 78 | 2002 |

Rigorous valid ranges for optimally reduced kinetic models OO Oluwole, B Bhattacharjee, JE Tolsma, PI Barton, WH Green Combustion and Flame 146 (1-2), 348-365, 2006 | 77 | 2006 |

On computational differentiation JE Tolsma, PI Barton Computers & chemical engineering 22 (4-5), 475-490, 1998 | 68 | 1998 |

Hidden discontinuities and parametric sensitivity calculations JE Tolsma, PI Barton SIAM Journal on Scientific Computing 23 (6), 1861-1874, 2002 | 55 | 2002 |

Construction of convex relaxations using automated code generation techniques EP Gatzke, JE Tolsma, PI Barton Optimization and Engineering 3 (3), 305-326, 2002 | 51 | 2002 |

Symbolic incorporation of external procedures into process modeling environments JE Tolsma, JA Clabaugh, PI Barton Industrial & engineering chemistry research 41 (16), 3867-3876, 2002 | 48 | 2002 |

Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic … HC Chien, AA Zur, TS Maurer, SW Yee, J Tolsma, P Jasper, DO Scott, ... Drug Metabolism and Disposition 44 (3), 356-364, 2016 | 42 | 2016 |

Bridging the gap between in vitro and in vivo: dose and schedule predictions for the ATR inhibitor AZD6738 S Checkley, L MacCallum, J Yates, P Jasper, H Luo, J Tolsma, ... Scientific reports 5 (1), 1-12, 2015 | 41 | 2015 |

Preclinical to clinical translation of antibody-drug conjugates using PK/PD modeling: a retrospective analysis of inotuzumab ozogamicin AM Betts, N Haddish-Berhane, J Tolsma, P Jasper, LE King, Y Sun, ... The AAPS journal 18 (5), 1101-1116, 2016 | 27 | 2016 |

Computation of heteroazeotropes. Part I: Theory JE Tolsma, PI Barton Chemical engineering science 55 (18), 3817-3834, 2000 | 22 | 2000 |

Computation of heteroazeotropes. Part II: Efficient calculation of changes in phase equilibrium structure JE Tolsma, PI Barton Chemical engineering science 55 (18), 3835-3853, 2000 | 15 | 2000 |

Systems pharmacology model of gastrointestinal damage predicts species differences and optimizes clinical dosing schedules H Shankaran, A Cronin, J Barnes, P Sharma, J Tolsma, P Jasper, ... CPT: pharmacometrics & systems pharmacology 7 (1), 26-33, 2018 | 14 | 2018 |

Efficient calculation of sparse Jacobians JE Tolsma, PI Barton SIAM Journal on Scientific Computing 20 (6), 2282-2296, 1999 | 13 | 1999 |

Analysis of heteroazenotropic systems JE Tolsma Massachusetts Institute of Technology, 1999 | 11 | 1999 |

Analysis of heteroazenotropic systems JE Tolsma Massachusetts Institute of Technology, 1999 | 11 | 1999 |

Quantitative systems pharmacology modeling of acid sphingomyelinase deficiency and the enzyme replacement therapy olipudase alfa is an innovative tool for linking … CD Kaddi, B Niesner, R Baek, P Jasper, J Pappas, J Tolsma, J Li, ... CPT: pharmacometrics & systems pharmacology 7 (7), 442-452, 2018 | 8 | 2018 |

ABACUSS II: Advanced modeling environment and embedded simulator JA Clabaugh, JE Tolsma, PI Barton Technical report, Massachusetts Institute of Technology, 2000. http://yoric …, 1999 | 8 | 1999 |