| Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose DJ Creek, M Mazet, F Achcar, J Anderson, DH Kim, R Kamour, P Morand, ... PLoS pathogens 11 (3), e1004689, 2015 | 127 | 2015 |
| mzMatch–ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data A Chokkathukalam, A Jankevics, DJ Creek, F Achcar, MP Barrett, ... Bioinformatics 29 (2), 281-283, 2013 | 106 | 2013 |
| Revisiting gametocyte biology in malaria parasites P Ngotho, AB Soares, F Hentzschel, F Achcar, L Bertuccini, M Marti FEMS microbiology reviews 43 (4), 401-414, 2019 | 98 | 2019 |
| Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei EJ Kerkhoven, F Achcar, VP Alibu, RJ Burchmore, IH Gilbert, M Trybiło, ... PLoS computational biology 9 (12), e1003371, 2013 | 52 | 2013 |
| AutoClass@ IJM: a powerful tool for Bayesian classification of heterogeneous data in biology F Achcar, JM Camadro, D Mestivier Nucleic acids research 37 (suppl_2), W63-W67, 2009 | 50 | 2009 |
| Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli KM Rattigan, AW Pountain, C Regnault, F Achcar, IM Vincent, ... PloS one 13 (3), e0194126, 2018 | 42 | 2018 |
| LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes DH Kim, F Achcar, R Breitling, KE Burgess, MP Barrett Metabolomics 11, 1721-1732, 2015 | 42 | 2015 |
| Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei PC Steketee, IM Vincent, F Achcar, F Giordani, DH Kim, DJ Creek, ... PLoS neglected tropical diseases 12 (5), e0006450, 2018 | 38 | 2018 |
| TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei S Shameer, FJ Logan-Klumpler, F Vinson, L Cottret, B Merlet, F Achcar, ... Nucleic acids research 43 (D1), D637-D644, 2015 | 38 | 2015 |
| Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism F Achcar, EJ Kerkhoven, SilicoTryp Consortium, BM Bakker, MP Barrett, ... PLoS computational biology 8 (1), e1002352, 2012 | 37 | 2012 |
| Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes M Zoltner, GD Campagnaro, G Taleva, A Burrell, M Cerone, KF Leung, ... Journal of Biological Chemistry 295 (24), 8331-8347, 2020 | 29 | 2020 |
| Modeling challenges in the synthetic biology of secondary metabolism R Breitling, F Achcar, E Takano ACS synthetic biology 2 (7), 373-378, 2013 | 22 | 2013 |
| Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana J Kovářová, AW Pountain, D Wildridge, S Weidt, F Bringaud, ... PLoS Pathogens 14 (3), e1006953, 2018 | 21 | 2018 |
| Plasmodium falciparum Gametocyte Density and Infectivity in Peripheral Blood and Skin Tissue of Naturally Infected Parasite Carriers in Burkina Faso E Meibalan, A Barry, MP Gibbins, S Awandu, L Meerstein-Kessel, ... The Journal of Infectious Diseases 223 (10), 1822-1830, 2021 | 19 | 2021 |
| Trypanosoma brucei: meet the system F Achcar, EJ Kerkhoven, MP Barrett Current opinion in microbiology 20, 162-169, 2014 | 18 | 2014 |
| Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC–MS K Johnston, DH Kim, EJ Kerkhoven, R Burchmore, MP Barrett, F Achcar Bioscience reports 39 (5), BSR20181601, 2019 | 17 | 2019 |
| Explicit consideration of topological and parameter uncertainty gives new insights into a well‐established model of glycolysis F Achcar, MP Barrett, R Breitling The FEBS journal 280 (18), 4640-4651, 2013 | 15 | 2013 |
| A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress F Achcar, JM Camadro, D Mestivier BMC systems biology 5, 1-19, 2011 | 14 | 2011 |
| The silicon trypanosome: a test case of iterative model extension in systems biology F Achcar, A Fadda, JR Haanstra, EJ Kerkhoven, DH Kim, AE Leroux, ... Advances in microbial physiology 64, 115-143, 2014 | 8 | 2014 |
| Running on empty: a metabolomics approach to investigating changing energy metabolism during fasted exercise and rest G Blackburn, J Hay, C Skagen, E Paul, F Achcar, J Wilson, C Best, ... Metabolites 10 (10), 399, 2020 | 7 | 2020 |
Rainer BreitlingProfessor of Systems Biology, Manchester Institute of Biotechnology, University of ManchesterVerified email at manchester.ac.uk
