Selective and potent proteomimetic inhibitors of intracellular protein–protein interactions A Barnard, K Long, HL Martin, JA Miles, TA Edwards, DC Tomlinson, ... Angewandte Chemie 127 (10), 3003-3008, 2015 | 111 | 2015 |
Double quick, double click reversible peptide “stapling” CM Grison, GM Burslem, JA Miles, LKA Pilsl, DJ Yeo, Z Imani, ... Chemical Science 8 (7), 5166-5171, 2017 | 89 | 2017 |
Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection C Hodson, A Purkiss, JA Miles, H Walden Structure 22 (2), 337-344, 2014 | 87 | 2014 |
Hydrocarbon constrained peptides–understanding preorganisation and binding affinity JA Miles, DJ Yeo, P Rowell, S Rodriguez-Marin, CM Pask, SL Warriner, ... Chemical science 7 (6), 3694-3702, 2016 | 84 | 2016 |
An α‐Helix‐Mimicking 12, 13‐Helix: Designed α/β/γ‐Foldamers as Selective Inhibitors of Protein–Protein Interactions CM Grison, JA Miles, S Robin, AJ Wilson, DJ Aitken Angewandte Chemie International Edition 55 (37), 11096-11100, 2016 | 65 | 2016 |
Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers V Azzarito, JA Miles, J Fisher, TA Edwards, SL Warriner, AJ Wilson Chemical Science 6 (4), 2434-2443, 2015 | 65 | 2015 |
Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway C Hodson, AR Cole, LPC Lewis, JA Miles, A Purkiss, H Walden Journal of Biological Chemistry 286 (37), 32628-32637, 2011 | 63 | 2011 |
Orthogonal functionalisation of α-helix mimetics A Barnard, K Long, DJ Yeo, JA Miles, V Azzarito, GM Burslem, ... Organic & Biomolecular Chemistry 12 (35), 6794-6799, 2014 | 31 | 2014 |
Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium (III) compounds LJ Liu, B He, JA Miles, W Wang, Z Mao, WI Che, JJ Lu, XP Chen, ... Oncotarget 7 (12), 13965, 2016 | 28 | 2016 |
The Fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL JA Miles, MG Frost, E Carroll, ML Rowe, MJ Howard, A Sidhu, ... Journal of Biological Chemistry 290 (34), 20995-21006, 2015 | 27 | 2015 |
Multivalent helix mimetics for PPI-inhibition A Barnard, JA Miles, GM Burslem, AM Barker, AJ Wilson Organic & Biomolecular Chemistry 13 (1), 258-264, 2015 | 25 | 2015 |
A catalytic protein–proteomimetic complex: using aromatic oligoamide foldamers as activators of RNase S Z Hegedus, CM Grison, JA Miles, S Rodriguez-Marin, SL Warriner, ... Chemical Science 10 (14), 3956-3962, 2019 | 20 | 2019 |
Evaluating the conformation of recombinant domain I of β2-glycoprotein I and its interaction with human monoclonal antibodies C Pericleous, J Miles, D Esposito, A Garza-Garcia, PC Driscoll, ... Molecular Immunology 49 (1-2), 56-63, 2011 | 17 | 2011 |
Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro JA Miles, P Machattou, D Nevin-Jones, ME Webb, A Millard, DJ Scanlan, ... Biochemical and biophysical research communications 510 (1), 27-34, 2019 | 12 | 2019 |
Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs** JA Miles, F Hobor, CH Trinh, J Taylor, C Tiede, PR Rowell, BR Jackson, ... ChemBioChem 22 (1), 232-240, 2021 | 11 | 2021 |
A case study of eukaryogenesis: the evolution of photoreception by photolyase/cryptochrome proteins JA Miles, TA Davies, RD Hayman, G Lorenzen, J Taylor, M Anjarwalla, ... Journal of molecular evolution 88, 662-673, 2020 | 6 | 2020 |
The evolutionary origins of peroxynitrite signalling JA Miles, JL Egan, JA Fowler, P Machattou, AD Millard, CJ Perry, ... Biochemical and Biophysical Research Communications 580, 107-112, 2021 | 5 | 2021 |
Peptide & NMR spectroscopy studies of recombinant Domain I confirm conformationally correct Domain I and non-linear epitope binding to anti-Domain I antiphospholipid antibodies C Pericleous, T Disu, J Miles, D Esposito, A Garza-Garcia, P Driscoll, ... | 2 | 2010 |
Inhibition of Aurora‐A/N‐Myc Protein–Protein Interaction Using Peptidomimetics: Understanding the Role of Peptide Cyclization RS Dawber, D Gimenez, M Batchelor, JA Miles, MH Wright, R Bayliss, ... ChemBioChem 25 (2), e202300649, 2024 | | 2024 |
Mechanisms of monoubiquitination in the Fanconi anemia pathway JA Miles UCL (University College London), 2014 | | 2014 |