Research Leader - Isomorphic Labs (Alphabet company), Honorary Group Leader - UCL
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Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
S Turajlic, K Litchfield, H Xu, R Rosenthal, N McGranahan, JL Reading, ...
The lancet oncology 18 (8), 1009-1021, 2017
Tracking cancer evolution reveals constrained routes to metastases: TRACERx renal
S Turajlic, H Xu, K Litchfield, A Rowan, T Chambers, JI Lopez, D Nicol, ...
Cell 173 (3), 581-594. e12, 2018
Meta-analysis of tumor-and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
K Litchfield, JL Reading, C Puttick, K Thakkar, C Abbosh, R Bentham, ...
Cell 184 (3), 596-614. e14, 2021
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal
S Turajlic, H Xu, K Litchfield, A Rowan, S Horswell, T Chambers, ...
Cell 173 (3), 595-610. e11, 2018
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies
FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ...
Cancer cell 33 (4), 649-663. e4, 2018
Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
PC Haycock, S Burgess, A Nounu, J Zheng, GN Okoli, J Bowden, ...
JAMA oncology 3 (5), 636-651, 2017
Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx renal
TJ Mitchell, S Turajlic, A Rowan, D Nicol, JHR Farmery, T O’Brien, ...
Cell 173 (3), 611-623. e17, 2018
UVB-induced tumor heterogeneity diminishes immune response in melanoma
Y Wolf, O Bartok, S Patkar, GB Eli, S Cohen, K Litchfield, R Levy, ...
Cell 179 (1), 219-235. e21, 2019
Pervasive chromosomal instability and karyotype order in tumour evolution
TBK Watkins, EL Lim, M Petkovic, S Elizalde, NJ Birkbak, GA Wilson, ...
Nature 587 (7832), 126-132, 2020
Lung adenocarcinoma promotion by air pollutants
W Hill, EL Lim, CE Weeden, C Lee, M Augustine, K Chen, FC Kuan, ...
Nature 616 (7955), 159-167, 2023
Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours
K Litchfield, B Summersgill, S Yost, R Sultana, K Labreche, D Dudakia, ...
Nature communications 6 (1), 5973, 2015
Metastasis and immune evasion from extracellular cGAMP hydrolysis
J Li, MA Duran, N Dhanota, WK Chatila, SE Bettigole, J Kwon, RK Sriram, ...
Cancer discovery 11 (5), 1212-1227, 2021
Cancer evolution: Darwin and beyond
R Vendramin, K Litchfield, C Swanton
The EMBO journal 40 (18), e108389, 2021
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma
L Au, E Hatipoglu, MR de Massy, K Litchfield, G Beattie, A Rowan, ...
Cancer cell 39 (11), 1497-1518. e11, 2021
Genomic evolution and chemoresistance in germ-cell tumours
A Taylor-Weiner, T Zack, E O’Donnell, JL Guerriero, B Bernard, A Reddy, ...
Nature 540 (7631), 114-118, 2016
Optimizing panel-based tumor mutational burden (TMB) measurement
J Budczies, M Allgäuer, K Litchfield, E Rempel, P Christopoulos, D Kazdal, ...
Annals of Oncology 30 (9), 1496-1506, 2019
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
K Litchfield, M Levy, G Orlando, C Loveday, PJ Law, G Migliorini, ...
Nature genetics 49 (7), 1133-1140, 2017
Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia
HE Speedy, B Kinnersley, D Chubb, P Broderick, PJ Law, K Litchfield, ...
Blood, The Journal of the American Society of Hematology 128 (19), 2319-2326, 2016
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
C Abbosh, AM Frankell, T Harrison, J Kisistok, A Garnett, L Johnson, ...
Nature 616 (7957), 553-562, 2023
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
Z Wang, KA McGlynn, E Rajpert-De Meyts, DT Bishop, CC Chung, ...
Nature genetics 49 (7), 1141-1147, 2017
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