| A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity JB Bramsen, MB Laursen, AF Nielsen, TB Hansen, C Bus, N Langkjær, ... Nucleic acids research 37 (9), 2867-2881, 2009 | 431 | 2009 |
| Synthesis and antiherpes virus activity of 1, 5-anhydrohexitol nucleosides I Verheggen, A Van Aerschot, S Toppet, R Snoeck, G Janssen, J Balzarini, ... Journal of medicinal chemistry 36 (14), 2033-2040, 1993 | 211 | 1993 |
| 1′, 5′‐Anhydrohexitol oligonucleotides: synthesis, base pairing and recognition by regular oligodeoxyribonucleotides and oligoribonucleotides C Hendrix, H Rosemeyer, I Verheggen, A Van Aerschot, F Seela, ... Chemistry–A European Journal 3 (1), 110-120, 1997 | 205 | 1997 |
| Cyclohexene nucleic acids (CeNA): serum stable oligonucleotides that activate RNase H and increase duplex stability with complementary RNA J Wang, B Verbeure, I Luyten, E Lescrinier, M Froeyen, C Hendrix, ... Journal of the American Chemical Society 122 (36), 8595-8602, 2000 | 196 | 2000 |
| Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides P Herdewijn, J Balzarini, M Baba, R Pauwels, A Van Aerschot, G Janssen, ... Journal of medicinal chemistry 31 (10), 2040-2048, 1988 | 169 | 1988 |
| Synthesis, biological evaluation, and structure analysis of a series of new 1, 5-anhydrohexitol nucleosides I Verheggen, A Van Aerschot, L Van Meervelt, J Rozenski, L Wiebe, ... Journal of medicinal chemistry 38 (5), 826-835, 1995 | 162 | 1995 |
| Antimicrobial resistance in bacteria K Bockstael, A Van Aerschot Central European Journal of Medicine 4, 141-155, 2009 | 144 | 2009 |
| 1, 5‐Anhydrohexitol nucleic acids, a new promising antisense construct A Aerschot Van, I Verheggen, C Hendrix, P Herdewijn Angewandte Chemie International Edition in English 34 (12), 1338-1339, 1995 | 144 | 1995 |
| 3'-Fluoro-2', 3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'-and 3'-fluorinated 2', 3'-dideoxynucleoside analogs A Van Aerschot, P Herdewijn, J Balzarini, R Pauwels, E De Clercq Journal of medicinal chemistry 32 (8), 1743-1749, 1989 | 143 | 1989 |
| Aminoacyl-tRNA synthetase inhibitors as potential antibiotics GHM Vondenhoff, A Van Aerschot European journal of medicinal chemistry 46 (11), 5227-5236, 2011 | 136 | 2011 |
| Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides H Kang, MH Fisher, D Xu, YJ Miyamoto, A Marchand, A Van Aerschot, ... Nucleic Acids Research 32 (14), 4411-4419, 2004 | 133 | 2004 |
| Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents AA Van Aerschot, P Mamos, NJ Weyns, S Ikeda, E De Clercq, ... Journal of medicinal chemistry 36 (20), 2938-2942, 1993 | 129 | 1993 |
| Anti-HIV-1 activity of 2′, 3′-dideoxinucleoside analogues: Structure-activity relationship E De Clercq, A Van Aerschot, P Herdewijn, M Baba, R Pauwels, ... Nucleosides Nucleotides & Nucleic Acids 8 (5-6), 659-671, 1989 | 128 | 1989 |
| Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation N Dias, S Dheur, PE Nielsen, S Gryaznov, A Van Aerschot, P Herdewijn, ... Journal of molecular biology 294 (2), 403-416, 1999 | 110 | 1999 |
| Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness CLMJ Verlinde, M Callens, S Van Calenbergh, A Van Aerschot, ... Journal of medicinal chemistry 37 (21), 3605-3613, 1994 | 110 | 1994 |
| A Methyl Group Controls Conformational Equilibrium in Human Mitochondrial tRNALys F Voigts-Hoffmann, M Hengesbach, AY Kobitski, A Van Aerschot, ... Journal of the American Chemical Society 129 (44), 13382-13383, 2007 | 105 | 2007 |
| Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability K Augustyns, F Vandendriessche, A Van Aerschot, R Busson, C Urbanke, ... Nucleic acids research 20 (18), 4711-4716, 1992 | 100 | 1992 |
| 1′, 5′‐Anhydrohexitol Oligonucleotides: Hybridisation and Strand Displacement with Oligoribonucleotides, Interaction with RNase H and HIV Reverse Transcriptase C Hendrix, H Rosemeyer, B De Bouvere, A Van Aerschot, F Seela, ... Chemistry–A European Journal 3 (9), 1513-1520, 1997 | 98 | 1997 |
| Synthesis and conformational study of 3-hydroxy-4-(hydroxymethyl)-1-cyclohexanyl purines and pyrimidines Y Maurinsh, J Schraml, H De Winter, N Blaton, O Peeters, E Lescrinier, ... The Journal of Organic Chemistry 62 (9), 2861-2871, 1997 | 97 | 1997 |
| Inhibition of MDR1 expression with altritol-modified siRNAs M Fisher, M Abramov, A Van Aerschot, D Xu, RL Juliano, P Herdewijn Nucleic acids research 35 (4), 1064-1074, 2007 | 96 | 2007 |
eveline.lescrinier@kuleuven.beProfessor Medicinal Chemistry, KU LeuvenVerified email at kuleuven.be
