Wiep Klaas Smits
Wiep Klaas Smits
Assistant Professor/Principal Investigator, Leiden University Medical Center
Verified email at lumc.nl - Homepage
TitleCited byYear
Bistability, epigenetics, and bet-hedging in bacteria
JW Veening, WK Smits, OP Kuipers
Annu. Rev. Microbiol. 62, 193-210, 2008
8112008
Phenotypic variation in bacteria: the role of feedback regulation
WK Smits, OP Kuipers, JW Veening
Nature Reviews Microbiology 4 (4), 259, 2006
4782006
Stripping Bacillus: ComK auto‐stimulation is responsible for the bistable response in competence development
WK Smits, CC Eschevins, KA Susanna, S Bron, OP Kuipers, LW Hamoen
Molecular microbiology 56 (3), 604-614, 2005
2062005
PrimeView Clostridium difficile infection
WK Smits, D Lyras, DB Lacy, MH Wilcox, EJ Kuijper
Nature Reviews Disease Primers 16021, 1, 2016
185*2016
Clostridium difficile infection
WK Smits, D Lyras, DB Lacy, MH Wilcox, EJ Kuijper
Nature Reviews Disease Primers 16020, 1-20, 2016
1852016
Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach
LW Hamoen, WK Smits, A Jong, S Holsappel, OP Kuipers
Nucleic acids research 30 (24), 5517-5528, 2002
1342002
Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data
RJS Baerends, WK Smits, A de Jong, LW Hamoen, J Kok, OP Kuipers
Genome biology 5 (5), R37, 2004
872004
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions
M Albano, WK Smits, LTY Ho, B Kraigher, I Mandic-Mulec, OP Kuipers, ...
Journal of Bacteriology 187 (6), 2010-2019, 2005
812005
Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media
JW Veening, WK Smits, LW Hamoen, OP Kuipers
Journal of applied microbiology 101 (3), 531-541, 2006
772006
Temporal separation of distinct differentiation pathways by a dual specificity Rap‐Phr system in Bacillus subtilis
WK Smits, C Bongiorni, JW Veening, LW Hamoen, OP Kuipers, M Perego
Molecular microbiology 65 (1), 103-120, 2007
752007
Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism
LJ Pettit, HP Browne, L Yu, WK Smits, RP Fagan, L Barquist, MJ Martin, ...
BMC genomics 15 (1), 160, 2014
722014
TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm
D Bakker, WK Smits, EJ Kuijper, J Corver
PloS one 7 (8), e43247, 2012
712012
Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis
JW Veening, WK Smits, LW Hamoen, JDH Jongbloed, OP Kuipers
Appl. Environ. Microbiol. 70 (11), 6809-6815, 2004
712004
The transcriptional regulator Rok binds A+ T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis
WK Smits, AD Grossman
PLoS genetics 6 (11), e1001207, 2010
682010
Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo
WK Smits, AI Goranov, AD Grossman
Molecular microbiology 75 (2), 452-461, 2010
652010
Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries
ÁT Kovács, WK Smits, AM Mirończuk, OP Kuipers
Environmental microbiology 11 (8), 1911-1922, 2009
562009
C. difficile 630Δerm Spo0A regulates sporulation, but does not contribute to toxin production, by direct high-affinity binding to target DNA
KE Rosenbusch, D Bakker, EJ Kuijper, WK Smits
PloS one 7 (10), e48608, 2012
512012
Chromosomal replication initiation machinery of low-G+ C-content Firmicutes
GS Briggs, WK Smits, P Soultanas
Journal of bacteriology 194 (19), 5162-5170, 2012
472012
Hype or hypervirulence: A reflection on problematic C. difficile strains
WK Smits
Virulence 4 (7), 592-596, 2013
432013
Tricksy business: transcriptome analysis reveals the involvement of thioredoxin A in redox homeostasis, oxidative stress, sulfur metabolism, and cellular differentiation in …
WK Smits, JYF Dubois, S Bron, JM van Dijl, OP Kuipers
Journal of bacteriology 187 (12), 3921-3930, 2005
422005
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Articles 1–20