| Principles of interleukin (IL)-6-type cytokine signalling and its regulation PC Heinrich, I Behrmann, S Haan, HM Hermanns, G Müller-Newen, ... Biochemical journal 374 (1), 1-20, 2003 | 4171 | 2003 |
| Interleukin-6 and the acute phase response. PC Heinrich, JV Castell, T Andus Biochemical journal 265 (3), 621, 1990 | 3787 | 1990 |
| Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway PC Heinrich, I Behrmann, G Müller-Newen, F Schaper, L Graeve Biochemical journal 334 (2), 297-314, 1998 | 2916 | 1998 |
| Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes JV Castell, MJ Gómez-Lechón, M David, T Andus, T Geiger, R Trullenque, ... FEBS letters 242 (2), 237-239, 1989 | 1167 | 1989 |
| Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 C Lütticken, UM Wegenka, J Yuan, J Buschmann, C Schindler, ... Science 263 (5143), 89-92, 1994 | 1046 | 1994 |
| Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6 JV Castell, MJ Gómez-lechón, M David, R Fabra, R Trullenque, ... Hepatology 12 (5), 1179-1186, 1990 | 990 | 1990 |
| Soluble receptors for cytokines and growth factors: generation and biological function. S Rose-John, PC Heinrich Biochemical Journal 300 (Pt 2), 281, 1994 | 987 | 1994 |
| Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level UM Wegenka, JAN Buschmann, C Lütticken, PC Heinrich, F Horn Molecular and cellular biology 13 (1), 276-288, 1993 | 717 | 1993 |
| The soluble interleukin‐6 receptor is generated by shedding J Mülberg, H Schooltink, T Stoyan, M Günther, L Graeve, G Buse, ... European journal of immunology 23 (2), 473-480, 1993 | 660 | 1993 |
| Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes JV Castell, MJ Gómez-Lechón, M David, T Hirano, T Kishimoto, ... FEBS letters 232 (2), 347-350, 1988 | 642 | 1988 |
| Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels JA Wedzicha, TAR Seemungal, PK MacCallum, EA Paul, GC Donaldson, ... Thrombosis and haemostasis 84 (08), 210-215, 2000 | 633 | 2000 |
| A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6. D Guschin, N Rogers, J Briscoe, B Witthuhn, D Watling, F Horn, ... The EMBO journal 14 (7), 1421-1429, 1995 | 615 | 1995 |
| SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130 J Schmitz, M Weissenbach, S Haan, PC Heinrich, F Schaper Journal of Biological Chemistry 275 (17), 12848-12856, 2000 | 542 | 2000 |
| Induction of rat acute‐phase proteins by interleukin 6 in vivo T Geiger, T Andus, J Klapproth, T Hirano, T Kishimoto, PC Heinrich European journal of immunology 18 (5), 717-721, 1988 | 533 | 1988 |
| Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins. A Mackiewicz, H Schooltink, PC Heinrich, S Rose-John Journal of immunology (Baltimore, Md.: 1950) 149 (6), 2021-2027, 1992 | 485 | 1992 |
| Hepatic acute phase proteins–regulation by IL-6-and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling JG Bode, U Albrecht, D Häussinger, PC Heinrich, F Schaper European journal of cell biology 91 (6-7), 496-505, 2012 | 450 | 2012 |
| Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis MM Neis, B Peters, A Dreuw, J Wenzel, T Bieber, C Mauch, T Krieg, ... Journal of Allergy and Clinical Immunology 118 (4), 930-937, 2006 | 447 | 2006 |
| Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3 C Niemand, A Nimmesgern, S Haan, P Fischer, F Schaper, R Rossaint, ... The journal of immunology 170 (6), 3263-3272, 2003 | 444 | 2003 |
| Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-β2) regulates β-fibrinogen and albumin mRNA levels in Fao-9 cells T Andus, T Geiger, T Hirano, H Northoff, U Ganter, J Bauer, T Kishimoto, ... FEBS letters 221 (1), 18-22, 1987 | 441 | 1987 |
| IFN‐α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling‐3 JG Bode, S Ludwig, C Ehrhardt, A Erhardt, U Albrecht, F Schaper, ... The FASEB Journal 17 (3), 1-16, 2003 | 414 | 2003 |
