Matthias P. Wymann

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Emilio HirschUniversity of TorinoVerified email at unito.it
Fiorella AltrudaVerified email at unito.it
Bernd GieseProfessor of Chemistry, University of BaselVerified email at unifr.ch
Marketa ZvelebilAssistant Professor in Cancer Informatics, ICRVerified email at icr.ac.uk
Chiara BorsariUniversity of MilanVerified email at unimi.it
Roger L WilliamsGroup leader, Medical Research Council, Laboratory of Molecular BiologyVerified email at mrc-lmb.cam.ac.uk
Vladimir KatanaevUniversity of GenevaVerified email at unige.ch
Bart VanhaesebroeckUCL Cancer Institute, University College London, London UKVerified email at ucl.ac.uk
Alberto MantovaniDirettore Scientifico, Istituto Clinico Humanitas, Humanitas UniversityVerified email at humanitasresearch.it
Silvano SozzaniProfessor of Pathology, Sapienza University of RomeVerified email at uniroma1.it
John E BurkeProfessor of Biochemistry and Microbiology, University of VictoriaVerified email at uvic.ca
Cecilia GarlandaCapo Laboratorio, Istituto Clinico HumanitasVerified email at humanitasresearch.it
Giovanni SolinasUniversity of Gothenburg, Department of Molecular and Clinical MedicineVerified email at gu.se
Domingo F. Barber (ORCID: 0000-000...Centro Nacional de Biotecnología (CNB), CSIC, Madrid, Spain. ROR ID https://ror.org/015w4v032Verified email at cnb.csic.es
Louise WebbThe Babraham Institute Lymphocyte Signalling and DevelopmentVerified email at babraham.ac.uk
Martin TurnerThe Babraham Institute, Cambridge, CB22 3AT, UK.Verified email at babraham.ac.uk
Klaus OkkenhaugDivision of Immunology, Department of Pathology, University of CambridgeVerified email at cam.ac.uk
Abdul DullooUniversity of Fribourg, SwitzerlandVerified email at unifr.ch
Ernst HafenETH ZurichVerified email at ethz.ch
Laurent MartinezINSERMVerified email at inserm.fr

Matthias P. Wymann

Department of Biomedicine, University of Basel, Switzerland

Verified email at UniBas.CH - Homepage

inflammation cancer cellular signaling phosphoinositides PI3K


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Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation E Hirsch, VL Katanaev, C Garlanda, O Azzolino, L Pirola, L Silengo, ... Science 287 (5455), 1049-1053, 2000	1564	2000
Lipid signalling in disease MP Wymann, R Schneiter Nature reviews Molecular cell biology 9 (2), 162-176, 2008	1529	2008
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine EH Walker, ME Pacold, O Perisic, L Stephens, PT Hawkins, MP Wymann, ... Molecular cell 6 (4), 909-919, 2000	1492	2000
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses A Arcaro, MP Wymann Biochemical Journal 296 (2), 297-301, 1993	1469	1993
Structure and function of phosphoinositide 3-kinases MP Wymann, L Pirola Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 1998	922	1998
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis M Camps, T Rückle, H Ji, V Ardissone, F Rintelen, J Shaw, C Ferrandi, ... Nature medicine 11 (9), 936-943, 2005	902	2005
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction MP Wymann, G Bulgarelli-Leva, MJ Zvelebil, L Pirola, B Vanhaesebroeck, ... Molecular and cellular biology, 1996	901	1996
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways MA Crackower, GY Oudit, I Kozieradzki, R Sarao, H Sun, T Sasaki, ... Cell 110 (6), 737-749, 2002	785	2002
Targeting phosphoinositide 3-kinase—moving towards therapy R Marone, V Cmiljanovic, B Giese, MP Wymann Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1784 (1), 159-185, 2008	745	2008
PI3Kγ modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and-independent effects E Patrucco, A Notte, L Barberis, G Selvetella, A Maffei, M Brancaccio, ... Cell 118 (3), 375-387, 2004	602	2004
Phosphoinositide 3-kinase signalling–which way to target? MP Wymann, M Zvelebil, M Laffargue Trends in pharmacological sciences 24 (7), 366-376, 2003	592	2003
Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK T Bondeva, L Pirola, G Bulgarelli-Leva, I Rubio, R Wetzker, MP Wymann Science 282 (5387), 293-296, 1998	437	1998
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons HY Man, Q Wang, WY Lu, W Ju, G Ahmadian, L Liu, S D'Souza, TP Wong, ... Neuron 38 (4), 611-624, 2003	436	2003
Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function M Laffargue, R Calvez, P Finan, A Trifilieff, M Barbier, F Altruda, E Hirsch, ... Immunity 16 (3), 441-451, 2002	391	2002
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils AM Condliffe, K Davidson, KE Anderson, CD Ellson, T Crabbe, ... Blood 106 (4), 1432-1440, 2005	384	2005
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, rho‐, and rac‐dependent signaling pathways S Attoub, V Noe, L Pirola, E Bruyneel, E Chastre, M Mareel, MP Wymann, ... The FASEB Journal 14 (14), 2329-2338, 2000	326	2000
Turning on the respiratory burst M Baggiolini, MP Wymann Trends in biochemical sciences 15 (2), 69-72, 1990	304	1990
PI (3) Kγ has an important context-dependent role in neutrophil chemokinesis GJ Ferguson, L Milne, S Kulkarni, T Sasaki, S Walker, S Andrews, ... Nature cell biology 9 (1), 86-91, 2007	297	2007
Phosphoinositide 3-kinase p110β activity: key role in metabolism and mammary gland cancer but not development E Ciraolo, M Iezzi, R Marone, S Marengo, C Curcio, C Costa, O Azzolino, ... Science signaling 1 (36), ra3-ra3, 2008	294	2008
Resistance to thromboembolism in PI3Kγ‐deficient mice E Hirsch, O Bosco, P Tropel, M Laffargue, R Calvez, F Altruda, ... The FASEB Journal 15 (11), 2019-2021, 2001	280	2001

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