Jim A Searles
Jim A Searles
Verified email at pfizer.com
Title
Cited by
Cited by
Year
The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature‐controlled shelf
JA Searles, JF Carpenter, TW Randolph
Journal of pharmaceutical sciences 90 (7), 860-871, 2001
3732001
Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization
JA Searles, JF Carpenter, TW Randolph
Journal of pharmaceutical sciences 90 (7), 872-887, 2001
2982001
Elements of quality by design in development and scale-up of freeze-dried parenterals
SL Nail, JA Searles
BioPharm International 21 (1), 44, 2008
892008
Viable cell recycle with an inclined settler in the perfusion culture of suspended recombinant Chinese hamster ovary cells
J Searles, P Todd, D Kompala
Biotechnology progress 10 (2), 198-206, 1994
761994
Freezing and annealing phenomena in lyophilization
JA Searles
Freeze-drying/lyophilization of pharmaceutical and biological products, 109-145, 2004
672004
Observation and implications of sonic water vapor flow during freeze-drying
J Searles
American Pharmaceutical Review 7, 58-69, 2004
602004
Recommended best practices for process monitoring instrumentation in pharmaceutical freeze drying—2017
S Nail, S Tchessalov, E Shalaev, A Ganguly, E Renzi, F Dimarco, ...
AAPS PharmSciTech 18 (7), 2379-2393, 2017
482017
Near-critical fluid micronization of stabilized vaccines, antibiotics and anti-virals
RE Sievers, BP Quinn, SP Cape, JA Searles, CS Braun, P Bhagwat, ...
The Journal of supercritical fluids 42 (3), 385-391, 2007
422007
Dry powder measles vaccine: particle deposition, virus replication, and immune response in cotton rats following inhalation
KO Kisich, MP Higgins, I Park, SP Cape, L Lindsay, DJ Bennett, S Winston, ...
Vaccine 29 (5), 905-912, 2011
352011
Freezing and annealing phenomena in lyophilization: Effects upon primary drying rate, morphology, and heterogeneity
TW Randolph, JA Searles
American Pharmaceutical Review 5, 40-47, 2002
242002
Computational and experimental investigation of flow and particle settling in a roller bottle bioreactor
FJ Muzzio, DR Unger, M Liu, J Bramble, J Searles, P Fahnestock
Biotechnology and bioengineering 63 (2), 185-196, 1999
171999
Development and Optimization of the Freeze‐Drying Processes
F Jameel, J Searles
Formulation and process development strategies for manufacturing …, 2010
122010
Perfusion culture of suspended CHO cells employing inclined sedimentation
JA Searles, P Todd, DS Kompala
Animal cell technology, 240-242, 1994
81994
Primary Drying Rate Heterogeneity During Pharmaceutical Lyophilization
JA Searles, JF Carpenter, TW Randolph
AMERICAN PHARMACEUTICAL REVIEW 3, 16-24, 2000
72000
Effects of chamber pressure and partial pressure of water vapor on secondary drying in lyophilization
JA Searles, S Aravapalli, C Hodge
AAPS PharmSciTech 18 (7), 2808-2813, 2017
62017
Challenges of developing a stable dry powder live viral vaccine
RE Sievers, SP Cape, KO Kisich, DJ Bennett, CS Braun, JL Burger, ...
proceedings of the Respiratory Drug Delivery, 11-15, 2008
62008
Method of improved mixing in roller bottles
JL Bramble, FJ Muzzio, JA Searles
US Patent 6,096,544, 2000
62000
Spray drying of biopharmaceuticals and vaccines
J Searles, G Mohan
Formulation and Process Development Strategies for Manufacturing …, 2010
52010
Development and Optimization of the Freeze-Drying Processes in Jameel, F., Iershenson, S. I, Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
F Jameel, J Searles
John Wiley and Sons, Inc., New Jersey, 2010
42010
Heterogeneity phenomena in pharmaceutical lyophilization
JA Searles
University of Colorado, 2000
42000
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