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Colin R. Groom
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The Cambridge structural database
CR Groom, IJ Bruno, MP Lightfoot, SC Ward
Acta Crystallographica Section B: Structural Science, Crystal Engineeringá…, 2016
64392016
The druggable genome
AL Hopkins, CR Groom
Nature reviews Drug discovery 1 (9), 727-730, 2002
36702002
Ligand efficiency: a useful metric for lead selection.
AL Hopkins, CR Groom, A Alex
Drug discovery today 9 (10), 430-431, 2004
18442004
The Cambridge Structural Database in retrospect and prospect
CR Groom, FH Allen
Angewandte Chemie International Edition 53 (3), 662-671, 2014
10432014
Three-dimensional structure of diferric bovine lactoferrin at 2.8 ┼ resolution
SA Moore, BF Anderson, CR Groom, M Haridas, EN Baker
Journal of molecular biology 274 (2), 222-236, 1997
4471997
Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography
Z B÷cskei, CR Groom, DR Flower, CE Wright, SEV Phillips, A Cavaggioni, ...
Nature 360 (6400), 186-188, 1992
4471992
Report on the sixth blind test of organic crystal structure prediction methods
AM Reilly, RI Cooper, CS Adjiman, S Bhattacharya, AD Boese, ...
Acta Crystallographica Section B: Structural Science, Crystal Engineeringá…, 2016
4352016
A review of methods for the calculation of solution free energies and the modelling of systems in solution
RE Skyner, JL McDonagh, CR Groom, T Van Mourik, JBO Mitchell
Physical Chemistry Chemical Physics 17 (9), 6174-6191, 2015
3702015
Heteroaromatic rings of the future
WR Pitt, DM Parry, BG Perry, CR Groom
Journal of medicinal chemistry 52 (9), 2952-2963, 2009
2882009
Atomic interactions and profile of small molecules disrupting protein–protein interfaces: the TIMBAL database
AP Higueruelo, A Schreyer, GRJ Bickerton, WR Pitt, CR Groom, ...
Chemical biology & drug design 74 (5), 457-467, 2009
1812009
Experimental and computational mapping of the binding surface of a crystalline protein
AC English, CR Groom, RE Hubbard
Protein engineering 14 (1), 47-59, 2001
1462001
Locating interaction sites on proteins: the crystal structure of thermolysin soaked in 2% to 100% isopropanol
AC English, SH Done, LSD Caves, CR Groom, RE Hubbard
Proteins: Structure, Function, and Bioinformatics 37 (4), 628-640, 1999
1431999
1.8 ┼ crystal structure of the C-terminal domain of rabbit serum haemopexin
HR Faber, CR Groom, HM Baker, WT Morgan, A Smith, EN Baker
Structure 3 (6), 551-559, 1995
1311995
Knowledge-based approaches to co-crystal design
PA Wood, N Feeder, M Furlow, PTA Galek, CR Groom, E Pidcock
CrystEngComm 16 (26), 5839-5848, 2014
1162014
The good, the bad and the twisted: a survey of ligand geometry in protein crystal structures
J Liebeschuetz, J Hennemann, T Olsson, CR Groom
Journal of computer-aided molecular design 26 (2), 169-183, 2012
972012
Evaluation of molecular crystal structures using Full Interaction Maps
PA Wood, TSG Olsson, JC Cole, SJ Cottrell, N Feeder, PTA Galek, ...
CrystEngComm 15 (1), 65-72, 2013
892013
IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo [1, 2-a] pyridine binding
GM Buckley, TA Ceska, JL Fraser, L Gowers, CR Groom, AP Higueruelo, ...
Bioorganic & medicinal chemistry letters 18 (11), 3291-3295, 2008
822008
Identifying interactions that determine fragment binding at protein hotspots
CJ Radoux, TSG Olsson, WR Pitt, CR Groom, TL Blundell
Journal of medicinal chemistry 59 (9), 4314-4325, 2016
732016
The Hydrogen Bond Environments of 1H-Tetrazole and Tetrazolate Rings: The Structural Basis for Tetrazole–Carboxylic Acid Bioisosterism
FH Allen, CR Groom, JW Liebeschuetz, DA Bardwell, TSG Olsson, ...
Journal of chemical information and modeling 52 (3), 857-866, 2012
682012
Identification, classification and relative stability of tautomers in the cambridge structural database
AJ Cruz-Cabeza, CR Groom
CrystEngComm 13 (1), 93-98, 2011
662011
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Articles 1–20