| ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice K Kaufmann, I Romaine, E Days, C Pascual, A Malik, L Yang, B Zou, Y Du, ... ACS chemical neuroscience 4 (9), 1278-1286, 2013 | 158 | 2013 |
| Metabolism and distribution of clozapine-N-oxide: implications for nonhuman primate chemogenetics J Raper, RD Morrison, JS Daniels, L Howell, J Bachevalier, T Wichmann, ... ACS chemical neuroscience 8 (7), 1570-1576, 2017 | 123 | 2017 |
| Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models GJ Digby, MJ Noetzel, M Bubser, TJ Utley, AG Walker, NE Byun, ... Journal of Neuroscience 32 (25), 8532-8544, 2012 | 120 | 2012 |
| The discovery and characterization of ML218: a novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson’s … Z Xiang, AD Thompson, JT Brogan, ML Schulte, BJ Melancon, D Mi, ... ACS chemical neuroscience 2 (12), 730-742, 2011 | 118 | 2011 |
| Design, Synthesis, and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform … RR Lavieri, SA Scott, PE Selvy, K Kim, S Jadhav, RD Morrison, JS Daniels, ... Journal of medicinal chemistry 53 (18), 6706-6719, 2010 | 100 | 2010 |
| The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in … CK Jones, M Bubser, AD Thompson, JW Dickerson, N Turle-Lorenzo, ... Journal of Pharmacology and Experimental Therapeutics 340 (2), 404-421, 2012 | 98 | 2012 |
| Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe E Delpire, A Baranczak, AG Waterson, K Kim, N Kett, RD Morrison, ... Bioorganic & medicinal chemistry letters 22 (14), 4532-4535, 2012 | 95 | 2012 |
| Discovery of (R)-(2-Fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-Hydroxypiperidin-1-yl)methanone (ML337), An mGlu3 Selective and CNS Penetrant Negative … CJ Wenthur, R Morrison, AS Felts, KA Smith, JL Engers, FW Byers, ... Journal of medicinal chemistry 56 (12), 5208-5212, 2013 | 89 | 2013 |
| Potentiation of M 1 muscarinic receptor reverses plasticity deficits and negative and cognitive symptoms in a schizophrenia mouse model A Ghoshal, JM Rook, JW Dickerson, GN Roop, RD Morrison, ... Neuropsychopharmacology 41 (2), 598-610, 2016 | 77 | 2016 |
| Discovery of a selective and CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 with antidepressant and anxiolytic activity in rodents JL Engers, AL Rodriguez, LC Konkol, RD Morrison, AD Thompson, ... Journal of medicinal chemistry 58 (18), 7485-7500, 2015 | 70 | 2015 |
| Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1, 3, 8-Triazaspiro [4.5] decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in … MC O’Reilly, SA Scott, KA Brown, TH Oguin III, PG Thomas, JS Daniels, ... Journal of medicinal chemistry 56 (6), 2695-2699, 2013 | 68 | 2013 |
| Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182 … CK Jones, DW Engers, AD Thompson, JR Field, AL Blobaum, ... Journal of medicinal chemistry 54 (21), 7639-7647, 2011 | 65 | 2011 |
| Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics HP Cho, PM Garcia-Barrantes, JT Brogan, CR Hopkins, CM Niswender, ... ACS chemical biology 9 (10), 2334-2346, 2014 | 54 | 2014 |
| Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor … TM Bridges, JM Rook, MJ Noetzel, RD Morrison, Y Zhou, RD Gogliotti, ... Drug Metabolism and Disposition 41 (9), 1703-1714, 2013 | 47 | 2013 |
| Targeting selective activation of M1 for the treatment of Alzheimer’s disease: further chemical optimization and pharmacological characterization of the M1 positive allosteric … JC Tarr, ML Turlington, PR Reid, TJ Utley, DJ Sheffler, HP Cho, R Klar, ... ACS chemical neuroscience 3 (11), 884-895, 2012 | 45 | 2012 |
| Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs JL Engers, KA Bollinger, RL Weiner, AL Rodriguez, MF Long, MM Breiner, ... ACS medicinal chemistry letters 8 (9), 925-930, 2017 | 41 | 2017 |
| The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 RD Morrison, AL Blobaum, FW Byers, TS Santomango, TM Bridges, ... Drug Metabolism and Disposition 40 (9), 1834-1845, 2012 | 41 | 2012 |
| Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM DJ Sheffler, CJ Wenthur, JA Bruner, SJS Carrington, PN Vinson, KK Gogi, ... Bioorganic & medicinal chemistry letters 22 (12), 3921-3925, 2012 | 41 | 2012 |
| Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator … DW Engers, AL Blobaum, RD Gogliotti, YY Cheung, JM Salovich, ... ACS chemical neuroscience 7 (9), 1192-1200, 2016 | 39 | 2016 |
| Discovery of (S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): A Novel, CNS … LC Morris, KD Nance, PR Gentry, EL Days, CD Weaver, CM Niswender, ... Journal of medicinal chemistry 57 (23), 10192-10197, 2014 | 38 | 2014 |
Craig LindsleyVanderbilt UniversityVerified email at vanderbilt.edu
