Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders J Spaas, L van Veggel, M Schepers, A Tiane, J van Horssen, DM Wilson, ... Cellular and Molecular Life Sciences, 1-23, 2021 | 114 | 2021 |
From OPC to Oligodendrocyte: An Epigenetic Journey A Tiane, M Schepers, B Rombaut, R Hupperts, J Prickaerts, N Hellings, ... Cells 8 (10), 1236, 2019 | 89 | 2019 |
Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model J Bogie, C Hoeks, M Schepers, A Tiane, A Cuypers, F Leijten, ... Scientific reports 9, 2019 | 62 | 2019 |
Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds M Schepers, N Martens, A Tiane, K Vanbrabant, HB Liu, D Lütjohann, ... Neural Regeneration Research 15 (5), 790, 2020 | 45 | 2020 |
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors D Paes, M Schepers, B Rombaut, D van den Hove, T Vanmierlo, ... Pharmacological Reviews 73 (3), 1016-1049, 2021 | 39 | 2021 |
Targeting Phosphodiesterases—Towards a Tailor-Made Approach in Multiple Sclerosis Treatment M Schepers, A Tiane, D Paes, S Sanchez, B Rombaut, E Piccart, ... Frontiers in immunology 10, 1727, 2019 | 38 | 2019 |
Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination E Houben, K Janssens, D Hermans, J Vandooren, C Van den Haute, ... Proceedings of the National Academy of Sciences 117 (9), 5028-5038, 2020 | 33 | 2020 |
Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion A Santiago, LM Soares, M Schepers, H Milani, T Vanmierlo, J Prickaerts, ... Neuropharmacology 138, 360-370, 2018 | 33 | 2018 |
Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation A Roggeri, M Schepers, A Tiane, B Rombaut, L van Veggel, N Hellings, ... International Journal of Molecular Sciences 21 (20), 7537, 2020 | 25 | 2020 |
DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation A Tiane, M Schepers, R Riemens, B Rombaut, P Vandormael, V Somers, ... Cellular and Molecular Life Sciences, 1-14, 2021 | 23 | 2021 |
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis M Schepers, D Paes, A Tiane, B Rombaut, E Piccart, L van Veggel, ... Brain, Behavior, and Immunity, 2022 | 19 | 2022 |
Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue L Ponsaerts, L Alders, M Schepers, RMW de Oliveira, J Prickaerts, ... Biomedicines 9 (7), 703, 2021 | 19 | 2021 |
Increased isoform-specific phosphodiesterase 4D (PDE4D) expression is associated with pathology and cognitive impairment in Alzheimer’s disease D Paes, R Lardenoije, RM Carollo, JAY Roubroeks, M Schepers, ... Neurobiology of Aging, 2020 | 18 | 2020 |
24 (S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer’s Disease N Martens, M Schepers, N Zhan, F Leijten, G Voortman, A Tiane, ... Marine Drugs 19 (4), 190, 2021 | 16 | 2021 |
Early-postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets E Nelissen, J De Vry, A Antonides, D Paes, M Schepers, FJ van der Staay, ... International Journal of Developmental Neuroscience 59, 47-51, 2017 | 15 | 2017 |
PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity B Rombaut, S Kessels, M Schepers, A Tiane, D Paes, Y Solomina, ... THERANOSTICS 11 (5), 2080-2097, 2021 | 13 | 2021 |
Positive effects of roflumilast on behavior, neuroinflammation, and white matter injury in mice with global cerebral ischemia. ER Vilhena, JM Bonato, M Schepers, JKC Kunieda, H Milani, T Vanmierlo, ... Behavioural Pharmacology, 2021 | 8 | 2021 |
24 (R, S)-Saringosterol From artefact to a biological medical agent K Vanbrabant, D Van Meel, A Kerksiek, S Friedrichs, M Dubbeldam, ... The Journal of Steroid Biochemistry and Molecular Biology, 105942, 2021 | 8 | 2021 |
Unleashing Spinal Cord Repair: The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury F Mussen, JV Broeckhoven, N Hellings, M Schepers, T Vanmierlo International Journal of Molecular Sciences 24 (9), 8135, 2023 | 7 | 2023 |
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms E Nelissen, N Possemis, NP Van Goethem, M Schepers, ... Scientific reports 12 (1), 1-15, 2022 | 6 | 2022 |