Tilman Flock
Tilman Flock
Palantir Technologies | Former Fellow at University of Cambridge
Verified email at
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Universal allosteric mechanism for Gα activation by GPCRs
T Flock, CNJ Ravarani, D Sun, AJ Venkatakrishnan, M Kayikci, CG Tate, ...
Nature 524 (7564), 173-179, 2015
Selectivity determinants of GPCR–G-protein binding
T Flock, AS Hauser, N Lund, DE Gloriam, S Balaji, MM Babu
Nature 545 (7654), 317-322, 2017
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
AJ Venkatakrishnan, X Deupi, G Lebon, FM Heydenreich, T Flock, ...
Nature 536 (7617), 484-487, 2016
Controlling entropy to tune the functions of intrinsically disordered regions
T Flock, RJ Weatheritt, NS Latysheva, MM Babu
Current opinion in structural biology 26, 62-72, 2014
An online resource for GPCR structure determination and analysis
C Munk, E Mutt, V Isberg, LF Nikolajsen, JM Bibbe, T Flock, MA Hanson, ...
Nature methods 16 (2), 151-162, 2019
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
S Brinkmann-Chen, T Flock, JKB Cahn, CD Snow, EM Brustad, ...
Proceedings of the National Academy of Sciences 110 (27), 10946-10951, 2013
Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas
M Kayikci, AJ Venkatakrishnan, J Scott-Brown, CNJ Ravarani, T Flock, ...
Nature structural & molecular biology 25 (2), 185-194, 2018
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
D Mayer, FF Damberger, M Samarasimhareddy, M Feldmueller, ...
Nature communications 10 (1), 1261, 2019
Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
A Sente, R Peer, A Srivastava, M Baidya, AM Lesk, S Balaji, AK Shukla, ...
Nature structural & molecular biology 25 (6), 538-545, 2018
Structured and disordered facets of the GPCR fold
AJ Venkatakrishnan, T Flock, DE Prado, ME Oates, J Gough, MM Babu
Current Opinion in Structural Biology 27, 129-137, 2014
Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity
CJ Tsai, F Pamula, R Nehmé, J Mühle, T Weinert, T Flock, P Nogly, ...
Science advances 4 (9), eaat7052, 2018
Probing Gαi1 protein activation at single–amino acid resolution
D Sun, T Flock, X Deupi, S Maeda, M Matkovic, S Mendieta, D Mayer, ...
Nature structural & molecular biology 22 (9), 686-694, 2015
Molecular principles of gene fusion mediated rewiring of protein interaction networks in cancer
NS Latysheva, ME Oates, L Maddox, T Flock, J Gough, M Buljan, ...
Molecular cell 63 (4), 579-592, 2016
Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
CJ Tsai, J Marino, R Adaixo, F Pamula, J Muehle, S Maeda, T Flock, ...
Elife 8, e46041, 2019
How do disordered regions achieve comparable functions to structured domains?
NS Latysheva, T Flock, RJ Weatheritt, S Chavali, MM Babu
Protein Science 24 (6), 909-922, 2015
Exploiting sequence and stability information for directing nanobody stability engineering
P Kunz, T Flock, N Soler, M Zaiss, C Vincke, Y Sterckx, D Kastelic, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1861 (9), 2196-2205, 2017
Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins
E Natan, T Endoh, L Haim-Vilmovsky, T Flock, G Chalancon, JTS Hopper, ...
Nature structural & molecular biology 25 (3), 279-288, 2018
Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish
E Gerrard, E Mutt, T Nagata, M Koyanagi, T Flock, E Lesca, GFX Schertler, ...
Proceedings of the National Academy of Sciences 115 (24), 6201-6206, 2018
Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation
CNJ Ravarani, T Flock, S Chavali, M Anandapadamanaban, MM Babu, ...
Nature Communications 11 (1), 2384, 2020
Deciphering membrane protein structures from protein sequences
T Flock, AJ Venkatakrishnan, KR Vinothkumar, MM Babu
Genome biology 13, 1-4, 2012
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