Niels Henning Skotte
Niels Henning Skotte
Post doctoral fellow, CPR
Verified email at cpr.ku.dk
TitleCited byYear
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene/allele-specific silencing of mutant huntingtin
JB Carroll, SC Warby, AL Southwell, CN Doty, S Greenlee, N Skotte, ...
Molecular Therapy 19 (12), 2178-2185, 2011
1962011
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
ME Østergaard, AL Southwell, H Kordasiewicz, AT Watt, NH Skotte, ...
Nucleic acids research 41 (21), 9634-9650, 2013
1202013
Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases
AL Southwell, NH Skotte, CF Bennett, MR Hayden
Trends in molecular medicine 18 (11), 634-643, 2012
932012
Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients
NH Skotte, AL Southwell, ME Østergaard, JB Carroll, SC Warby, CN Doty, ...
PloS one 9 (9), e107434, 2014
902014
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ...
Human molecular genetics 19 (8), 1528-1538, 2010
882010
In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides
AL Southwell, NH Skotte, HB Kordasiewicz, ME Østergaard, AT Watt, ...
Molecular Therapy 22 (12), 2093-2106, 2014
802014
Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in Huntington disease patients of European ancestry
C Kay, JA Collins, NH Skotte, AL Southwell, SC Warby, NS Caron, ...
Molecular Therapy 23 (11), 1759-1771, 2015
652015
A fully humanized transgenic mouse model of Huntington disease
AL Southwell, SC Warby, JB Carroll, CN Doty, NH Skotte, W Zhang, ...
Human molecular genetics 22 (1), 18-34, 2012
592012
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response
B Rotblat, AL Southwell, DE Ehrnhoefer, NH Skotte, M Metzler, ...
Proceedings of the National Academy of Sciences 111 (8), 3032-3037, 2014
542014
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice
V Uribe, BKY Wong, RK Graham, CL Cusack, NH Skotte, MA Pouladi, ...
Human molecular genetics 21 (9), 1954-1967, 2012
522012
Personalized gene silencing therapeutics for Huntington disease
C Kay, NH Skotte, AL Southwell, MR Hayden
Clinical genetics 86 (1), 29-36, 2014
502014
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin
DE Ehrnhoefer, NH Skotte, S Ladha, YTN Nguyen, X Qiu, Y Deng, ...
Human molecular genetics 23 (3), 717-729, 2013
342013
Reduced gluconeogenesis and lactate clearance in Huntington's disease
K Josefsen, SMB Nielsen, A Campos, T Seifert, L Hasholt, JE Nielsen, ...
Neurobiology of disease 40 (3), 656-662, 2010
232010
A quantitative method for the specific assessment of caspase-6 activity in cell culture
DE Ehrnhoefer, NH Skotte, J Savill, YTN Nguyen, S Ladha, LP Cao, ...
PLoS One 6 (11), e27680, 2011
202011
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
AL Southwell, HB Kordasiewicz, D Langbehn, NH Skotte, MP Parsons, ...
Science translational medicine 10 (461), eaar3959, 2018
162018
Site-specific characterization of endogenous SUMOylation across species and organs
IA Hendriks, D Lyon, D Su, NH Skotte, JA Daniel, LJ Jensen, ML Nielsen
Nature communications 9 (1), 2456, 2018
162018
Palmitoylation of caspase-6 by HIP14 regulates its activation
NH Skotte, SS Sanders, RR Singaraja, DE Ehrnhoefer, K Vaid, X Qiu, ...
Cell death and differentiation 24 (3), 433, 2017
162017
Integrative characterization of the R6/2 mouse model of Huntington’s disease reveals dysfunctional astrocyte metabolism
NH Skotte, JV Andersen, A Santos, BI Aldana, CW Willert, A Nørremølle, ...
Cell reports 23 (7), 2211-2224, 2018
142018
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
DE Ehrnhoefer, DDO Martin, ME Schmidt, X Qiu, S Ladha, NS Caron, ...
Acta neuropathologica communications 6 (1), 16, 2018
122018
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
AL Southwell, NH Skotte, EB Villanueva, ME Østergaard, X Gu, ...
Human molecular genetics 26 (6), 1115-1132, 2017
92017
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