Ngee Kiat (Jake) Chua
Ngee Kiat (Jake) Chua
Research Officer
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Cholesterol homeostasis: How do cells sense sterol excess?
V Howe, LJ Sharpe, SJ Alexopoulos, SV Kunze, NK Chua, D Li, AJ Brown
Chemistry and physics of lipids 199, 170-178, 2016
A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis
NK Chua, V Howe, N Jatana, L Thukral, AJ Brown
Journal of Biological Chemistry 292 (49), 19959-19973, 2017
The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change
V Howe, NK Chua, J Stevenson, AJ Brown
Journal of Biological Chemistry 290 (46), 27533-27544, 2015
A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate
H Yoshioka, HW Coates, NK Chua, Y Hashimoto, AJ Brown, K Ohgane
Proceedings of the National Academy of Sciences 117 (13), 7150-7158, 2020
The shape of human squalene epoxidase expands the arsenal against cancer
AJ Brown, NK Chua, N Yan
Nature communications 10 (1), 1-4, 2019
Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis.
SY Jun, AJ Brown, NK Chua, JY Yoon, JJ Lee, JOK Yang, IS Jang, ...
Gastroenterology, 2020
Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase
NK Chua, G Hart-Smith, AJ Brown
Journal of Biological Chemistry 294 (20), 8134-8147, 2019
Squalene monooxygenase: a journey to the heart of cholesterol synthesis
NK Chua, HW Coates, AJ Brown
Progress in Lipid Research, 101033, 2020
Cholesterol, cancer, and rebooting a treatment for athlete’s foot
NK Chua, HW Coates, AJ Brown
Science translational medicine 10 (437), 2018
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron
NK Chua, NA Scott, AJ Brown
Biochemical Journal 476 (18), 2545-2560, 2019
Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene
HW Coates, NK Chua, AJ Brown
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2019
Mallostery: Filling a niche between quality and metabolic control
NK Chua, AJ Brown
Journal of Biological Chemistry 293 (38), 14951-14952, 2018
Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydro‐cholesterol reductase
P Simonen, S Li, NK Chua, AM Lampi, V Piironen, J Lommi, J Sinisalo, ...
Journal of Internal Medicine, 2020
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
C Grohmann, CM Magtoto, JR Walker, NK Chua, A Gabrielyan, M Hall, ...
Nature Communications 13 (1), 1-13, 2022
Lipid sensing tips the balance for a key cholesterol synthesis enzyme
NK Chua, AJ Brown
Journal of lipid research 61 (11), 1363-1363, 2020
The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme
NK Chua, AJ Brown
Springer, New York, NY, 2020
Regulated protein degradation and lipid sensing: Lessons from a key cholesterol synthesis enzyme
NK Chua, AJ Brown
第三届中国生物物理学会代谢生物学分会学术研讨会论文集, 2019
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