|A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity|
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
|Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein|
C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, ...
Proceedings of the National Academy of Sciences 113 (26), 7065-7070, 2016
|Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation|
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ...
Proceedings of the National Academy of Sciences 113 (37), 10328-10333, 2016
|Protein microgels from amyloid fibril networks|
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, ...
ACS nano 9 (1), 43-51, 2015
|β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces|
JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ...
Scientific reports 6, 36010, 2016
|Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates|
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, ...
Angewandte Chemie International Edition 56 (27), 7750-7754, 2017
|Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity|
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, ...
ACS chemical biology 13 (3), 636-646, 2018
|Mapping surface hydrophobicity of α-synuclein oligomers at the nanoscale|
JE Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, ...
Nano letters 18 (12), 7494-7501, 2018
|Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine|
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
|Optical Structural Analysis of Individual α‐Synuclein Oligomers|
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, ...
Angewandte Chemie 130 (18), 4980-4984, 2018
|Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms|
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ...
Nature communications 10 (1), 1-11, 2019
|Quantifying co-oligomer formation by α-synuclein|
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ...
ACS nano 12 (11), 10855-10866, 2018
|Inhibiting the Ca2+ influx induced by human CSF|
A Drews, S De, P Flagmeier, DC Wirthensohn, WH Chen, DR Whiten, ...
Cell reports 21 (11), 3310-3316, 2017
|Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates|
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, ...
Proceedings of the National Academy of Sciences 114 (30), 8005-8010, 2017
|An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils|
ED Agerschou, P Flagmeier, T Saridaki, C Galvagnion, D Komnig, L Heid, ...
Elife 8, 2019
|Single-molecule characterization of the interactions between extracellular chaperones and toxic α-synuclein oligomers|
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, ...
Cell reports 23 (12), 3492-3500, 2018
|Nanoscopic characterisation of individual endogenous protein aggregates in human neuronal cells|
DR Whiten, Y Zuo, L Calo, ML Choi, S De, P Flagmeier, DC Wirthensohn, ...
ChemBioChem 19 (19), 2033-2038, 2018
|Increased secondary nucleation underlies accelerated aggregation of the four-residue N-terminally truncated Aβ42 species Aβ5–42|
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, ...
ACS chemical neuroscience 10 (5), 2374-2384, 2019
|Determination of Primary Nucleation Mechanisms of α-Synuclein Amyloid Aggregation|
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, ...
Biophysical Journal 106 (2), 268a, 2014
|The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils|
FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, ...
ACS nano, 2020