Diego Villar
Diego Villar
Non-clinical Lecturer, Blizard Institute, Queen Mary University of London
Verified email at - Homepage
Cited by
Cited by
Enhancer evolution across 20 mammalian species
D Villar, C Berthelot, S Aldridge, TF Rayner, M Lukk, M Pignatelli, TJ Park, ...
Cell 160 (3), 554-566, 2015
Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1
N Pescador, D Villar, D Cifuentes, M Garcia-Rocha, A Ortiz-Barahona, ...
PloS one 5 (3), e9644, 2010
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
N Pescador, Y Cuevas, S Naranjo, M Alcaide, D Villar, MO Landázuri, ...
Biochemical Journal 390 (1), 189-197, 2005
Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding …
A Ortiz-Barahona, D Villar, N Pescador, J Amigo, L del Peso
Nucleic acids research 38 (7), 2332-2345, 2010
Evolution of transcription factor binding in metazoans—mechanisms and functional implications
D Villar, P Flicek, DT Odom
Nature Reviews Genetics 15 (4), 221-233, 2014
Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression
C Berthelot, D Villar, JE Horvath, DT Odom, P Flicek
Nature ecology & evolution 2 (1), 152-163, 2018
Universal DNA methylation age across mammalian tissues
AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li, R Lowe, Q Yan, ...
Nature aging 3 (9), 1144-1166, 2023
Codon-driven translational efficiency is stable across diverse mammalian cell states
KLM Rudolph, BM Schmitt, D Villar, RJ White, JC Marioni, C Kutter, ...
PLoS genetics 12 (5), e1006024, 2016
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
JR Naranjo, H Zhang, D Villar, P González, XM Dopazo, J Morón-Oset, ...
The Journal of clinical investigation 126 (2), 627-638, 2016
Interaction between PARP-1 and HIF-2α in the hypoxic response
A Gonzalez-Flores, R Aguilar-Quesada, E Siles, S Pozo, ...
Oncogene 33 (7), 891-898, 2014
Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
D Villar, A Vara-Vega, MO Landázuri, L Del Peso
Biochemical Journal 408 (2), 231-240, 2007
Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions
D Villar, A Ortiz-Barahona, L Gómez-Maldonado, N Pescador, ...
PLoS One 7 (9), e45708, 2012
LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions
M Roller, E Stamper, D Villar, O Izuogu, F Martin, AM Redmond, ...
Genome biology 22, 1-43, 2021
DNA methylation networks underlying mammalian traits
A Haghani, CZ Li, TR Robeck, J Zhang, AT Lu, J Ablaeva, ...
Science 381 (6658), eabq5693, 2023
Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data
T Rensch, D Villar, J Horvath, DT Odom, P Flicek
Genome biology 17, 1-14, 2016
Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate
AJ Jasinska, I Zelaya, SK Service, CB Peterson, RM Cantor, OW Choi, ...
Nature genetics 49 (12), 1714-1721, 2017
Building the DREAM interactome
M Rivas, D Villar, P González, XM Dopazo, B Mellstrom, JR Naranjo
Science China Life Sciences 54, 786-792, 2011
The contribution of non-coding regulatory elements to cardiovascular disease
D Villar, S Frost, P Deloukas, A Tinker
Open Biology 10 (7), 200088, 2020
A role for insulator elements in the regulation of gene expression response to hypoxia
M Tiana, D Villar, E Perez-Guijarro, L Gomez-Maldonado, E Molto, ...
Nucleic acids research 40 (5), 1916-1927, 2012
Epigenetic predictors of maximum lifespan and other life history traits in mammals
CZ Li, A Haghani, TR Robeck, D Villar, AT Lu, J Zhang, CG Faulkes, H Vu, ...
BioRxiv, 2021.05. 16.444078, 2021
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