| Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex LM Machesky, RH Insall Current biology 8 (25), 1347-1356, 1998 | 1200 | 1998 |
| Phosphatidylinositol 4, 5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3 AL Rozelle, LM Machesky, M Yamamoto, MHE Driessens, RH Insall, ... Current Biology 10 (6), 311-320, 2000 | 630 | 2000 |
| Actin dynamics at the leading edge: from simple machinery to complex networks RH Insall, LM Machesky Developmental cell 17 (3), 310-322, 2009 | 494 | 2009 |
| Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions N Andrew, RH Insall Nature cell biology 9 (2), 193-200, 2007 | 444 | 2007 |
| Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence E Sapey, H Greenwood, G Walton, E Mann, A Love, N Aaronson, ... Blood, The Journal of the American Society of Hematology 123 (2), 239-248, 2014 | 357 | 2014 |
| Signaling to actin dynamics LM Machesky, RH Insall The Journal of cell biology 146 (2), 267-272, 1999 | 341 | 1999 |
| PIP3, PIP2, and cell movement—similar messages, different meanings? RH Insall, OD Weiner Developmental cell 1 (6), 743-747, 2001 | 257 | 2001 |
| WASP and SCAR/WAVE proteins: the drivers of actin assembly AY Pollitt, RH Insall Journal of cell science 122 (15), 2575-2578, 2009 | 243 | 2009 |
| Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour MP Neilson, DM Veltman, PJM van Haastert, SD Webb, JA Mackenzie, ... PLoS biology 9 (5), e1000618, 2011 | 204 | 2011 |
| CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. R Insall, A Kuspa, PJ Lilly, G Shaulsky, LR Levin, WF Loomis, ... The Journal of cell biology 126 (6), 1537-1545, 1994 | 199 | 1994 |
| The induction of autophagy by mechanical stress JS King, DM Veltman, RH Insall Autophagy 7 (12), 1490-1499, 2011 | 193 | 2011 |
| Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease E Sapey, JA Stockley, H Greenwood, A Ahmad, D Bayley, JM Lord, ... American journal of respiratory and critical care medicine 183 (9), 1176-1186, 2011 | 193 | 2011 |
| Chemotaxis: finding the way forward with Dictyostelium JS King, RH Insall Trends in cell biology 19 (10), 523-530, 2009 | 191 | 2009 |
| N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods X Yu, T Zech, L McDonald, EG Gonzalez, A Li, I Macpherson, JP Schwarz, ... Journal of cell biology 199 (3), 527-544, 2012 | 190 | 2012 |
| PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium SL Blagg, M Stewart, C Sambles, RH Insall Current Biology 13 (17), 1480-1487, 2003 | 179 | 2003 |
| Understanding eukaryotic chemotaxis: a pseudopod-centred view RH Insall Nature reviews molecular cell biology 11 (6), 453-458, 2010 | 175 | 2010 |
| Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis R Insall, A Müller‐Taubenberger, L Machesky, J Köhler, E Simmeth, ... Cell motility and the cytoskeleton 50 (3), 115-128, 2001 | 175 | 2001 |
| Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis M Carnell, T Zech, SD Calaminus, S Ura, M Hagedorn, SA Johnston, ... Journal of cell biology 193 (5), 831-839, 2011 | 172 | 2011 |
| The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium RH Insall, J Borleis, PN Devreotes Current Biology 6 (6), 719-729, 1996 | 164 | 1996 |
| The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration T Zech, SDJ Calaminus, P Caswell, HJ Spence, M Carnell, RH Insall, ... Journal of cell science 124 (22), 3753-3759, 2011 | 163 | 2011 |
Laura MacheskyDepartment of Biochemistry, University of CambridgeVerified email at beatson.gla.ac.uk
