Stanley C Xie
Stanley C Xie
Verified email at unimelb.edu.au
TitleCited byYear
Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance
C Dogovski, SC Xie, G Burgio, J Bridgford, S Mok, JM McCaw, ...
PLoS biology 13 (4), e1002132, 2015
1752015
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
N Klonis, SC Xie, JM McCaw, MP Crespo-Ortiz, SG Zaloumis, JA Simpson, ...
Proceedings of the National Academy of Sciences 110 (13), 5157-5162, 2013
1352013
Structure- and function-based design of Plasmodium-selective proteasome inhibitors
H Li, AJ O’Donoghue, WA van der Linden, SC Xie, E Yoo, IT Foe, L Tilley, ...
Nature 530 (7589), 233, 2016
1202016
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
SC Xie, C Dogovski, E Hanssen, F Chiu, T Yang, MP Crespo, C Stafford, ...
J Cell Sci 129 (2), 406-416, 2016
602016
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ...
Nature communications 9 (1), 3801, 2018
292018
Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum …
T Yang, SC Xie, P Cao, C Giannangelo, J McCaw, DJ Creek, ...
Antimicrobial agents and chemotherapy 60 (8), 4501-4510, 2016
292016
Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins
SC Xie, C Dogovski, S Kenny, L Tilley, N Klonis
International journal for parasitology 44 (12), 893-899, 2014
142014
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
SC Xie, DL Gillett, NJ Spillman, C Tsu, MR Luth, S Ottilie, S Duffy, ...
Journal of medicinal chemistry 61 (22), 10053-10066, 2018
122018
A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum
P Cao, N Klonis, S Zaloumis, C Dogovski, SC Xie, S Saralamba, LJ White, ...
Antimicrobial agents and chemotherapy 61 (12), e00618-17, 2017
52017
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis, CJ Morton, ...
Nature microbiology 4 (11), 1990-2000, 2019
32019
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance
T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie, JL Bridgford, ...
Cell reports 29 (9), 2917-2928. e5, 2019
12019
The proteasome as a target for protozoan parasites
SC Xie, LR Dick, A Gould, S Brand, L Tilley
Expert opinion on therapeutic targets, 1-12, 2019
2019
CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY
S Xie, M Griffin, R Metcalfe, E Hanssen, T Yang, D Gilley, A Leis, C Morton, ...
PROTEIN SCIENCE 28, 55-56, 2019
2019
Structure and Function of the Proteasome Activator PA28 of the Malaria Parasite Plasmodium falciparum
R Metcalf, E Hanssen, SC Xie, D Gillett, A Leis, C Morton, MW Parker, ...
Microscopy and Microanalysis 25 (S2), 1324-1325, 2019
2019
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
SC Xie, G Burgio, J Bridgford, S Mok, JM McCaw, K Chotivanich, S Kenny, ...
มหาวิทยาลัย มหิดล, 2019
2019
PHYSIOLOGICALLY RELEVANT EXPOSURE TO SYNTHETIC OZONIDE ANTIMALARIALS KILLS K13 WILDTYPE AND MUTANT PLASMODIUM FALCIPARUM MORE EFFECTIVELY THAN DIHYDROARTEMISININ
T Yang, SC Xie, P Cao, C Giannangelo, J McCaw, DJ Creek, ...
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 95 (5), 78-78, 2017
2017
CAPTURING DIFFERENTIAL PROTEIN TURNOVER DYNAMICS IN ARTEMISININ RESISTANT PLASMODIUM FALCIPARUM USING PULSE-SILAC
T Yang, S Cobbold, SC Xie, L Tilley
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 97 (5), 417-417, 2017
2017
Mechanism of action of artemisinin antimalarials and implications for drug resistance in Plasmodium falciparum
SC Xie
2015
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Articles 1–18