|The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice|
SM Solon-Biet, AC McMahon, JWO Ballard, K Ruohonen, LE Wu, ...
Cell metabolism 19 (3), 418-430, 2014
|IRS1-independent defects define major nodes of insulin resistance|
KL Hoehn, C Hohnen-Behrens, A Cederberg, LE Wu, N Turner, T Yuasa, ...
Cell metabolism 7 (5), 421-433, 2008
|Pigment epithelium-derived factor contributes to insulin resistance in obesity|
S Crowe, LE Wu, C Economou, SM Turpin, M Matzaris, KL Hoehn, ...
Cell metabolism 10 (1), 40-47, 2009
|Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging|
A Das, GX Huang, MS Bonkowski, A Longchamp, C Li, MB Schultz, ...
Cell 173 (1), 74-89. e20, 2018
|SIRT 2 induces the checkpoint kinase BubR1 to increase lifespan|
BJ North, MA Rosenberg, KB Jeganathan, AV Hafner, S Michan, J Dai, ...
The EMBO journal 33 (13), 1438-1453, 2014
|Hepatic fat loss in advanced nonalcoholic steatohepatitis: are alterations in serum adiponectin the cause?|
D van der Poorten, CF Samer, M Ramezani‐Moghadam, S Coulter, ...
Hepatology 57 (6), 2180-2188, 2013
|Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue–derived microvascular endothelial cells|
SL Hocking, LE Wu, M Guilhaus, DJ Chisholm, DE James
Diabetes 59 (12), 3008-3016, 2010
|Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity|
LE Wu, D Samocha-Bonet, PT Whitworth, DJ Fazakerley, N Turner, ...
Molecular metabolism 3 (4), 465-473, 2014
|Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells|
EA Carter, BS Rayner, AI McLeod, LE Wu, CP Marshall, A Levina, ...
Molecular Biosystems 6 (7), 1316-1322, 2010
|Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis|
LE Wu, AP Gomes, DA Sinclair
Cancer cell 25 (1), 12-19, 2014
|Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency|
GLM Cagnone, TS Tsai, Y Makanji, P Matthews, J Gould, MS Bonkowski, ...
Scientific reports 6 (1), 1-15, 2016
|Carcinogenic chromium (VI) compounds formed by intracellular oxidation of chromium (III) dietary supplements by adipocytes|
LE Wu, A Levina, HH Harris, Z Cai, B Lai, S Vogt, DE James, PA Lay
Angewandte Chemie 128 (5), 1774-1777, 2016
|Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival|
ME Nelson, S Lahiri, JDY Chow, FL Byrne, SR Hargett, DS Breen, ...
Nature communications 8 (1), 1-11, 2017
|Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance|
M Mohamad, SJ Mitchell, LE Wu, MY White, SJ Cordwell, J Mach, ...
Aging Cell 15 (4), 706-715, 2016
|NAD+ repletion rescues female fertility during reproductive aging|
MJ Bertoldo, DR Listijono, WHJ Ho, AH Riepsamen, DM Goss, D Richani, ...
Cell reports 30 (6), 1670-1681. e7, 2020
|Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction|
LE Wu, CC Meoli, SP Mangiafico, DJ Fazakerley, VC Cogger, ...
Diabetes 63 (8), 2656-2667, 2014
|Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions|
P Latorre-Muro, J Baeza, EA Armstrong, R Hurtado-Guerrero, F Corzana, ...
Molecular cell 71 (5), 718-732. e9, 2018
|Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach|
S Bustamante, T Jayasena, D Richani, RB Gilchrist, LE Wu, DA Sinclair, ...
Metabolomics 14 (1), 15, 2018
|Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes|
MKH Chowdhury, N Turner, NL Bentley, A Das, LE Wu, D Richani, ...
Scientific reports 7 (1), 1-9, 2017
|Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes|
A Riepsamen, L Wu, L Lau, D Listijono, W Ledger, D Sinclair, H Homer
PLoS One 10 (5), e0126194, 2015